Publications by authors named "Han J Kim"

Background: The phase 2 randomised Young-PEARL study demonstrated that palbociclib plus exemestane with ovarian function suppression significantly prolonged progression-free survival compared with capecitabine in premenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer. Here, we report results of the protocol-specified secondary endpoint of overall survival.

Methods: Young-PEARL was a multicentre, randomised, open-label, phase 2 study conducted at 14 institutions in South Korea.

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Purpose: To determine if iatrogenic posterior translation (UIV SPi) at the upper instrumented vertebrae (UIV) is associated with increased mechanical complications and secondarily to generate and validate a UIV SPi threshold for increased complications.

Methods: Two patient databases were utilized: one for generating a UIV SPi threshold and another for validation. Patients with a UIV between T8-L1 and a LIV at ilium were included.

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Background: The microbiome has been identified as a contributor to bone quality. As skeletal health is critical to success of orthopedic surgery, the gut microbiome may be a modifiable factor associated with postoperative outcomes. For spine fusion surgery in particular, bone formation and sufficient bone mineral density are essential for successful outcomes.

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Introduction: The COVID-19 pandemic is known to impact in-hospital processes for acute stroke patients, potentially resulting in delays due to quarantine and screening measures. The purpose of this study was to determine effects of changes in in-hospital quarantine policies on quality of care for acute stroke patients.

Methods: Hyperacute ischemic stroke patients who were admitted to Korea University Guro Hospital between January 2019 and February 2021 via the emergency department were included in this study.

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Background: Coronary angiography (CAG) and targeted temperature management (TTM) may improve clinical outcomes after out-of-hospital cardiac arrest. This study aimed to assess whether the intervention effects differed according to timing and percutaneous coronary intervention (PCI) performance.

Methods And Results: Adult patients with presumed cardiac cause who underwent CAG and TTM within 24 hours following out-of-hospital cardiac arrest were included from the Korean nationwide out-of-hospital cardiac arrest registry.

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Background Context: Correcting sagittal malalignment in adult spinal deformity (ASD) is a challenging task, often requiring complex surgical interventions like pedicle subtraction osteotomies (PSOs). Different types of three-column osteotomies (3COs), including Schwab 3, Schwab 4, Schwab 4 with interbody cages, and the "sandwich" technique, aim to optimize alignment and fusion outcomes. The role of interbody cages in enhancing fusion and segmental correction remains unclear.

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Patients with proximal junctional kyphosis (PJK) or failure (PJF) may demonstrate disparate outcomes and recovery when fused to the upper (UT) versus lower (LT) thoracic spine. Few studies have distinguished the reoperation and recovery abilities of patients with PJK or PJF when fused to the upper (UT) versus lower (LT) thoracic spine. Adult spine deformity patients ≥ 18 yrs with preoperative and 5-year (5Y) data fused to the sacrum/pelvis were included.

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Objective: Malalignment following cervical spine deformity (CSD) surgery can negatively impact outcomes and increase complications. Despite the growing ability to plan alignment, it remains unclear whether preoperative goals are achieved with surgery. The objective of this study was to assess how good surgeons are at achieving their preoperative goal alignment following CSD surgery.

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Article Synopsis
  • The study investigates how different reasons for revision surgery in adult spinal deformity (ASD) patients affect their postoperative outcomes, revealing a high incidence of reoperations.
  • A sample of 891 ASD patients was analyzed retrospectively, categorizing their revisions by cause, and assessing complications, radiographic results, and disability metrics.
  • Findings suggest that different etiologies (mechanical, infection, wound, and SI pain) lead to varying outcomes, with mechanical issues showing less improvement over time compared to others.
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The Rh blood type has 57 antigens, including D, C, E, c, and e. This blood type is clinically significant, alongside the ABO blood type. The anti-f(ce) antibody is an unexpected antibody that targets an antigen composed of the c and e antigens.

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  • Poor muscle health, indicated by the normalized total psoas area (NTPA), is linked to negative recovery outcomes in spinal deformity surgery, which is a gap in current research.
  • The study aims to explore how NTPA correlates with patient mobility and the incidence of adverse events (AEs) post-surgery by analyzing data from 279 patients over a nine-year period.
  • Results include assessing postoperative ambulation and complications like urinary issues and delayed healing, using data from MRI to establish cut-off values for NTPA related to patient recovery.
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Background And Objectives: The spectrum of patients requiring adult spinal deformity (ASD) surgery is highly variable in baseline (BL) risk such as age, frailty, and deformity severity. Although improvements have been realized in ASD surgery over the past decade, it is unknown whether these carry over to high-risk patients. We aim to determine temporal differences in outcomes at 2 years after ASD surgery in patients stratified by BL risk.

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Objective: The objective of this study was to identify baseline patient and surgical factors predictive of optimal outcomes in staged versus same-day combined-approach surgery.

Methods: Adult spinal deformity (ASD) patients with baseline and perioperative (by 6 weeks) data were stratified based on single-stage (same-day) or multistage (staged) surgery, excluding planned multiple hospitalizations. Means comparison analyses were used to assess baseline demographic, radiographic, and surgical differences between cohorts.

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Objective: The goal of this study was to assess the impact of fractional curve (FC) severity on curve progression and postoperative outcomes in patients undergoing adult idiopathic scoliosis (AdIS) correction.

Methods: Patients with AdIS who had preoperative coronal plane deformity and who had undergone thoracolumbar fusion with a lowermost instrumented vertebra (LIV) between L1 and L4 were included. Patients were stratified by 6-week postoperative FC severity (small FC, ≤ 40th percentile, large FC, ≥ 60th percentile of the entire cohort; calculated as the Cobb angle between LIV and S1) and age groups.

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Study Design: Retrospective analysis of prospectively collected data.

Objective: This study evaluates the impact of knee osteoarthritis (OA) and knee arthroplasty on alignments and patient-reported outcomes measures (PROMS) of patients undergoing adult spinal deformity (ASD) corrective surgery.

Background: The relationship between knee OA and spinal alignment in patients with ASD is incompletely understood.

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Purpose: To investigate the impact of the Global Alignment and Proportion (GAP) score components on patient outcomes in Adult Spine Deformity (ASD) surgery.

Methods: Patients included underwent assessment via the GAP score and its individual components: pelvic version (GAP PV), lumbar lordosis (GAP LL), lumbar distribution index (GAP LDI) and spinopelvic component (GAP SP). Multivariable analyses assessed the association between alignment in these components and clinical outcomes in ASD patients.

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Article Synopsis
  • Understanding preoperative deformity in lumbar spine revisions can help improve outcomes and prevent failures in future surgeries.
  • A study compared patients with no prior surgery (PRIMARY) and those with short (SHORT) or long (LONG) fusions, highlighting how different failure modes correlate with shorter fusions.
  • Results showed that revision patients experienced significant alignment issues and often required more invasive correction techniques, indicating a need for better alignment strategies in future operations.
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  • The study is a retrospective cohort analysis aimed at assessing the surgical outcomes of adult spinal deformity using AI-based clustering to categorize patients into different deformity types, including Moderate Sagittal, Severe Sagittal, Coronal, and Hyper-Thoracic Kyphosis.
  • A total of 1062 patients were analyzed, showing that while all deformity clusters experienced similar improvements in health-related quality of life after surgery, those in the Severe Sagittal cluster had notably higher complication rates, especially regarding major complications, reoperations, and implant failures.
  • Despite varying complication rates among clusters, the types of complications did not show significant differences, indicating that all clusters benefit equally from surgical interventions, achieving comparable rates of minimal clinically important difference in quality
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The purpose of this systematic review and meta-analysis is to assess existing literature and determine the association between the Hounsfield unit (HU) value and the vertebral body quality (VBQ) score with mechanical complications (MCs) after adult spinal deformity (ASD) surgery. Although bone quality is considered an increasingly important factor for MCs after ASD surgery, the utility of the HU value assessed by computed tomography and the VBQ score assessed by magnetic resonance imaging remains unknown. A systematic review of PubMed, Embase, and Cochrane Library databases was performed to find studies evaluating the association between the HU value and the VBQ score with MCs after ASD surgery.

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Article Synopsis
  • - The study is a secondary data analysis of an NIH-sponsored research focusing on cost-effectiveness between surgical and non-surgical treatments for Adult Symptomatic Lumbar Scoliosis (ASLS) eight years post-enrollment.
  • - Previous analyses at the five-year mark showed a cost-effectiveness ratio (ICER) of $44,033 (As-Treated) and $27,480 (Intent-to-treat), while the current eight-year data suggests that surgical treatment is more economically favorable, with an ICER of $20,569 per Quality Adjusted Life Year (QALY) gained.
  • - The conclusion highlights that operative treatment for ASLS presents a more cost-effective option compared to non-operative treatment, as indicated
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  • A recent study examined how preoperative factors impact recovery outcomes after cervical spine surgery, focusing specifically on patient-reported outcome measures (PROMs) to predict postoperative success in pain relief and functionality.
  • The research analyzed data from 139 patients who underwent surgery, using measures like the Neck Disability Index (NDI) and PROMIS assessments before and after the procedure.
  • Findings indicated that for overall patients, a 1-point increase in preoperative disability scores decreased the odds of achieving a satisfactory symptom state post-surgery, especially among those with radiculopathy, while showing different results for myelopathy patients.
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  • Tranexamic acid (TXA) is used in adult spinal deformity surgery to reduce blood loss, but there's no agreed-upon dosing method.
  • A study analyzed data from 265 complex ASD patients, categorizing them into low, medium, and high TXA dose groups and measuring blood loss, complications, and RBC transfusions.
  • Findings revealed that lower TXA doses resulted in significantly higher blood loss and increased RBC transfusions compared to high doses, suggesting that higher TXA dosing may be more effective in minimizing blood loss during surgery.
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Primary care physicians (PCPs) frequently serve pediatric patients with developmental delays and disorders (DD/D). Although the most widely used primary care behavioral health screener, the (), is validated for use with children without DD/D, it is unclear whether this measure accurately identifies behavioral health symptoms in youth with DD/D. Thus, the purpose of this study was to assess the psychometric properties of the for children with DD/D.

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  • This study explores the relationship between psoas muscle size (measured by cross-sectional area) and bone health in patients undergoing spine fusion surgery, highlighting the connection between muscle and bone health in surgical outcomes.
  • The research involved measuring psoas muscle area using CT scans and assessing bone density and microarchitecture with advanced imaging techniques in a cohort of 88 patients, revealing that larger psoas size correlates with better bone metrics.
  • Findings showed that while psoas size is linked to higher bone mineral density and better microarchitecture at certain sites, this relationship varied by sex and did not hold for lumbar spine bone density, indicating complex interactions between muscle and bone health.
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