Genetic engineering of megakaryocytes from blood progenitor cells using messenger RNA lipid nanoparticles.

Background: Platelets are an essential component of hemorrhage control and management, and engineering platelets to express therapeutic proteins could expand their use as a cell therapy. Genetically engineered platelets can be achieved by modifying the platelet precursor cells, megakaryocytes (MKs). Current strategies include transfecting MK progenitors ex vivo with viral vectors harboring lineage-driven transgenes and inducing the production of in vitro modified platelets.

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells.

T cells show tremendous efficacy as cellular therapeutics. However, obtaining primary T cells from human donors is expensive and variable. Pluripotent stem cells (PSCs) have the potential to provide a renewable source of T cells, but differentiating PSCs into hematopoietic progenitors with T cell potential remains an important challenge.

Additions to the knowledge of Nevada carabid beetles (Coleoptera: Carabidae) and a preliminary list of carabids from the Great Basin National Park.

Background: Additions to the list of Carabidae known for Nevada, USA and carabid beetles found in the Great Basin National Park, NV are reported with notes on ecology and identification resources.

New Information: For 79 species of carabids, we present 57 new state records, two state records previously reported in online resources, one confirmation of a previous questionable record for the state, and report 22 records for the Great Basin National Park that includes three new state records.

The catalytic incineration of trichloroethylene over a gamma-alumina supported manganese oxide catalyst.

TCE decomposition over a Mn2O3/gamma-Al2O3 catalyst in a fixed bed reactor was conducted in this study. Preliminarily, three catalysts including Mn2O3/gamma-Al2O3, NiO/gamma-Al2O3, and Pt/gamma-Al2O3 were used to incinerate TCE and the results show that the Mn2O3/gamma-Al2O3 catalyst has the best performance. The effects of operating parameters, such as inlet temperature, space velocity, TCE inlet concentration, and oxygen concentration on the catalytic incineration of TCE over the Mn2O3/gamma-Al2O3 catalyst were then performed.

Characterization of gamma-alumina-supported manganese oxide as an incineration catalyst for trichloroethylene.

Trichloroethylene (TCE) decomposition over a MnOx/ gamma-Al2O3 catalyst in a fixed-bed reactor was conducted in this study. The MnOx/gamma-Al2O3 powders were prepared by the incipient wetness impregnation method with aqueous solution of manganese nitrate. The catalysts were characterized by DTA-TGA, XRD, porosity analysis, SEM, EDX, and XPS.