Comprehensive Analysis of Tumor Immune Microenvironment and Prognosis of m6A-Related IncRNAs in Lung Adenocarcinoma.

Lung cancer is a fatal disease with high morbidity and mortality. As a major type of non-small cell lung cancer (NSCLC), lung adenocarcinoma (LUAD) has come into the focus of the biological and clinical research. Nevertheless, potential functions of N6-methyladenosine (m6A) methylation-related long non-coding RNAs (lncRNAs) in the tumor immune microenvironment (TIME) remain unclear.

Shell microelectrode arrays (MEAs) for brain organoids.

Brain organoids are important models for mimicking some three-dimensional (3D) cytoarchitectural and functional aspects of the brain. Multielectrode arrays (MEAs) that enable recording and stimulation of activity from electrogenic cells offer notable potential for interrogating brain organoids. However, conventional MEAs, initially designed for monolayer cultures, offer limited recording contact area restricted to the bottom of the 3D organoids.

UBE2G1 Is a Critical Component of Immune Response to the Infection of in Large Yellow Croaker ().

The large yellow croaker () is one of the most economically valuable mariculture fish in China. Infection of can cause an outbreak of "internal organ white-spot disease", which seriously affects the aquaculture of the large yellow croaker. Ubiquitylation is closely related to the post-translation modification of proteins and plays a vital role in many hosts' immune defense pathways, while the E2-binding enzyme is a key factor in ubiquitination.

Spatial Distribution Characteristics of the Rural Tourism Villages in the Qinghai-Tibetan Plateau and Its Influencing Factors.

The development of rural tourism (RT) has great significance in reducing poverty and achieving rural vitalization. Qinghai-Tibetan Plateau (QTP) is a depressed area with rich RT resources due to its unspoiled nature and diverse culture. For future sustainable development of RT in QTP, this paper analyzes the spatial distribution characteristics and its influencing factors of RT villages using various spatial analysis methods, such as nearest neighbor index, kernel density estimation, vector buffer analysis, and geographic detectors.

Specific anti-glioma targeted-delivery strategy of engineered small extracellular vesicles dual-functionalised by Angiopep-2 and TAT peptides.

Glioma is one of the primary malignant brain tumours in adults, with a poor prognosis. Pharmacological reagents targeting glioma are limited to achieve the desired therapeutic effect due to the presence of blood-brain barrier (BBB). Effectively crossing the BBB and specifically targeting to the brain tumour are the major challenge for the glioma treatments.

Overexpression of miR-651-5p inhibits ultraviolet radiation-induced malignant biological behaviors of sebaceous gland carcinoma cells by targeting .

Background: Ultraviolet (UV) exposure is the most essential etiological factor in sebaceous gland carcinoma (SGC). The abnormal expression of microRNAs (miRNAs) is also involved in SGC. However, the function of miRNAs in UV-induced SGC is still unclear.

Using Period Analysis to Timely Assess and Predict 5-Year Relative Survival for Liver Cancer Patients From Taizhou, Eastern China.

Introduction: While timely assessment of long-term survival for patients with liver cancer is essential for the evaluation of early detection and screening programs of liver cancer, those data are extremely scarce in China. We aimed to timely and accurately assess long-term survival for liver cancer patients in eastern China.

Methods: Patients diagnosed with liver cancer during 2004-2018 from four cancer registries with high-quality data from Taizhou, eastern China, were included.

PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer.

Resistance to PARP inhibitors (PARPi) remains a therapeutic challenge in ovarian cancer patients. PDZ-binding kinase (PBK) participates in the chemoresistance of many malignancies. However, the role of PBK in PARPi resistance of ovarian cancer is obscure.

A systematic review of deep learning methods for modeling electrocardiograms during sleep.

Sleep is one of the most important human physiological activities, and plays an essential role in human health. Polysomnography (PSG) is the gold standard for measuring sleep quality and disorders, but it is time-consuming, labor-intensive, and prone to errors. Current research has confirmed the correlations between sleep and the respiratory/circulatory system.

New Insights Into the Social Rumor Characteristics During the COVID-19 Pandemic in China.

Background: In the early stage of the COVID-19 outbreak in China, several social rumors in the form of false news, conspiracy theories, and magical cures had ever been shared and spread among the general public at an alarming rate, causing public panic and increasing the complexity and difficulty of social management. Therefore, this study aims to reveal the characteristics and the driving factors of the social rumors during the COVID-19 pandemic.

Methods: Based on a sample of 1,537 rumors collected from Sina Weibo's debunking account, this paper first divided the sample into four categories and calculated the risk level of all kinds of rumors.

COL1A1: A novel oncogenic gene and therapeutic target in malignancies.

Collagen type I alpha 1 (COL1A1), a member of the collagen family, is involved in epithelial-mesenchymal transition, which is closely linked to malignant tumorigenesis. COL1A1 is highly expressed in various cancers and regulates various cellular processes, including cell proliferation, metastasis, apoptosis, and cisplatin resistance. COL1A1 is also associated with cancer progression and prognosis; elevated COL1A1 expression is associated with poor prognosis in cancer patients.

Empagliflozin Attenuates Obesity-Related Kidney Dysfunction and NLRP3 Inflammasome Activity Through the HO-1-Adiponectin Axis.

Empagliflozin (EMPA) is a novel sodium-glucose cotransporter 2 inhibitor (SGLT2i) that produces protective cardiovascular-renal outcomes in patients with diabetes. However, the effects of EMPA on obesity-related kidney disease have not been determined. The heme oxygenase-1 (HO-1)-adiponectin axis is an essential antioxidant system with anti-apoptotic and anti-inflammatory properties.

Clinical Study of Intravitreal Injection of Anti-VEGF Drugs Combined with Triamcinolone Acetonide in the Treatment of Coats Disease.

Objective: To investigate the clinical study of intravitreal injection of anti-VEGF drugs combined with intravitreal injection of tretinoin for the treatment of Coats disease.

Methods: The medical records of 90 patients (120 eyes) with Coats disease admitted to our hospital from April 2010 to June 2021 were selected as retrospective study subjects and divided into control and treatment groups according to the numerical table method. There were 45 cases and 60 eyes in each group.

Towards Understanding PRPS1 as a Molecular Player in Immune Response in Yellow Drum ().

Phosphoribosyl pyrophosphate synthetases (EC 2.7.6.

Exploring phase-amplitude coupling from primary motor cortex-basal ganglia-thalamus network model.

The purpose of this study is to develop a primary motor cortex (M1)-basal ganglia-thalamus model capable of reproducing the physiological phenomenon of exaggerated phase-amplitude coupling (PAC) in Parkinson's disease and exploring the potential sources of PAC anomalies in M1. The subthalamic nucleus (STN) phase-STN amplitude coupling, STN phase-M1 amplitude coupling, and M1 phase-M1 amplitude coupling are reproduced, where the phase frequencies are distributed in the beta band and the amplitude frequencies are distributed in the broad gamma band. We mainly study the impacts of thalamus →M1 connections and STN↔M1 bidirectional synaptic connections.

A comparison of mood, quality of life and executive function among narcolepsy type 1 patients with or without ADHD symptoms in China.

Objective: To investigate the prevalence of core attention-deficit/hyperactivity disorder (ADHD) symptoms in Chinese narcolepsy type 1 (NT1) patients and to explore mood, quality of life, and executive function in narcolepsy patients with or without ADHD and the response to Methylphenidate Hydrochloride Extended-release tablets (ER-MPH) treatment.

Method: A total of 267 pediatric NT1 patients (194 males and 73 females, 5-17 years old) were evaluated for ADHD symptoms by a psychiatrist using the DSM-IV diagnostic criteria of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI Kid) from February 2011 to July 2013 at Peking University People's Hospital. All patients underwent Stanford Sleep Inventory (SSI) evaluation and polysomnography followed by multiple sleep latency tests (MSLT) before ER-MPH treatment.

Post-Translational Modifications of p53 in Ferroptosis: Novel Pharmacological Targets for Cancer Therapy.

The tumor suppressor p53 is a well-known cellular guardian of genomic integrity that blocks cell cycle progression or induces apoptosis upon exposure to cellular stresses. However, it is unclear how the remaining activities of p53 are regulated after the abrogation of these routine activities. Ferroptosis is a form of iron- and lipid-peroxide-mediated cell death; it is particularly important in p53-mediated carcinogenesis and corresponding cancer prevention.

Synthesis of FeO@CdS@CQDs ternary core-shell heterostructures as a magnetically recoverable photocatalyst for selective alcohol oxidation coupled with HO production.

Photocatalytic aerobic oxidation of aromatic alcohols to corresponding aldehydes coupled with producing hydrogen peroxide (HO) represents one of the most efficient strategies for converting solar energy into chemical energy. In this work, a magnetically recoverable photocatalyst of FeO@CdS@CQDs ternary core-shell heterostructures is elaborately fabricated through the hydrothermal growth of CdS on FeO nanospheres with in-situ incorporation of carbon quantum dots (CQDs) and used for selective alcohol oxidation coupled with HO production. The FeO@CdS@CQDs photocatalyst possess distinct advantages of full solar spectral absorption, efficient charge separation, and high stability.

Dual-Path Effect of Mortality Salience Induced by COVID-19 on Food Safety Behavior in China.

During the pandemic, the mortality salience of COVID-19 has affected everyone. The public is extremely sensitive to food safety, especially cold chain food and imported food. This research is based on the terror management theory, protective motivation theory, and self-construal theory.

Model-based optogenetic stimulation to regulate beta oscillations in Parkinsonian neural networks.

Optogenetic stimulation, an effective stimulation technique, is applied to the treatment of Parkinson's disease (PD) to compete with the current neuromodulation technology that focuses on the electrical stimulation. Using the cortical-thalamic-basal ganglia model, we systematically study the effect of optogenetic stimulation on pathological parkinsonian rhythmic neural activity. Based on the experimental studies, four types of neurons are selected as stimulation targets.

Thyroid Cancer and COVID-19: Prospects for Therapeutic Approaches and Drug Development.

Thyroid cancer is the most prevalent endocrine malignancy and the reported incidence of thyroid cancer has continued to increase in recent years. Since 2019, coronavirus disease 2019 (COVID-19) has been spreading worldwide in a global pandemic. COVID-19 aggravates primary illnesses and affects disease management; relevant changes include delayed diagnosis and treatment.

The Origins, Evolution, and Future of Dietary Methionine Restriction.

The original description of dietary methionine restriction (MR) used semipurified diets to limit methionine intake to 20% of normal levels, and this reduction in dietary methionine increased longevity by ∼30% in rats. The MR diet also produces paradoxical increases in energy intake and expenditure and limits fat deposition while reducing tissue and circulating lipids and enhancing overall insulin sensitivity. In the years following the original 1993 report, a comprehensive effort has been made to understand the nutrient sensing and signaling systems linking reduced dietary methionine to the behavioral, physiological, biochemical, and transcriptional components of the response.

Robust functional principal component analysis via a functional pairwise spatial sign operator.

Functional principal component analysis (FPCA) has been widely used to capture major modes of variation and reduce dimensions in functional data analysis. However, standard FPCA based on the sample covariance estimator does not work well if the data exhibits heavy-tailedness or outliers. To address this challenge, a new robust FPCA approach based on a functional pairwise spatial sign (PASS) operator, termed PASS FPCA, is introduced.