Echocardiography-guided percutaneous intramyocardial septal radiofrequency ablation procedure for the treatment of Fabry disease: a case report.

Background: This is a case report of a patient with Fabry disease (FD). We successfully treated a patient with ventricular septal hypertrophy and left ventricular outflow tract (LVOT) obstruction caused by FD. We report our exclusive new surgery for patients with LVOT obstruction, percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) procedure™ (percutaneous intramyocardial septal radiofrequency ablation).

Have human activities been accurately evaluated in sediment yield changes in the middle reaches of the Yellow River?

The middle reaches of the Yellow River (MRYR) in China are some of the most severely eroded areas in the world. Knowledge of the changes in sediment yield in the MRYR is of great significance for understanding the impact of human activities on soil erosion and sediment transport. Using data from the MRYR and 13 sub-basins, this study aims to evaluate the actual contributions of human activities to sediment yields and to examine whether the widely used Mann-Kendall test has underestimated this contribution.

A novel monoclonal antibody against human thymic stromal lymphopoietin for the treatment of TSLP-mediated diseases.

Introduction: Thymic stromal lymphopoietin (TSLP) is a master regulator of allergic inflammation against pathogens at barrier surfaces of the lung, skin, and gut. However, aberrant TSLP activity is implicated in various allergic, chronic inflammation and autoimmune diseases and cancers. Biologics drugs neutralizing excess TSLP activity represented by tezepelumab have been approved for severe asthma and are being evaluated for the treatments of other TSLP-mediated diseases.

[Anti-tumor effect of Inonotus obliquus extract on 4T1 tumor-bearing mice].

Objective: To explore the antitumor effect of Inonotus obliquus extract on 4T1 tumor-bearing mice in vivo and its possible mechanism.

Methods: 4T1 tumor-bearing mice model was established. After successful modeling, tumor-bearing mice were randomly divided into model control group, cyclophosphamide(CTX) positive group, and high, medium and low dose groups of Inonotus obliquus extract, with 10 mice in each group, which were administered continuously for 21 days.

Resveratrol ameliorates postoperative cognitive dysfunction in aged mice by regulating microglial polarization through CX3CL1/CX3CR1 signaling axis.

Postoperative cognitive dysfunction (POCD) is a common cognitive challenge faced by older adults. One of the key contributors to the development of POCD is neuroinflammation induced by microglia. Resveratrol has emerged as a promising candidate for the prevention of cognitive decline.

COSMIC-2 RFI Prediction Model Based on CNN-BiLSTM-Attention for Interference Detection and Location.

As the application of the Global Navigation Satellite System (GNSS) continues to expand, its stability and safety issues are receiving more and more attention, especially the interference problem. Interference reduces the signal reception quality of ground terminals and may even lead to the paralysis of GNSS function in severe cases. In recent years, Low Earth Orbit (LEO) satellites have been highly emphasized for their unique advantages in GNSS interference detection, and related commercial and academic activities have increased rapidly.

Evaluation of fission product yield distributions in the U(n, f) reaction.

In this work, the phenomenological potential-driving model based on the random neck rupture model is used to calculate and evaluate the independent yields and cumulative yields of fission products for the mass/charge distribution in the U(n, f) reaction with an incident neutron energy of 0.5 MeV and 14 MeV. In particular, the energy dependence of independent yields, including Kr, Sr, Zr, Mo, Ru, Xe, Cs, Ba and Ce, is evaluated for an incident neutron energy below 20 MeV and compared with GEFY6.

Evaluation of the performance of a qPCR-based assay for HIV-1 viral load determination.

Objective: According to the YY/T 1182-2010 standard of the People's Republic of China on nucleic acid amplification test reagents (kits) for medical industry, the accuracy, precision, linear range, and analytic sensitivity of HIV-1 standardized quality control products should be assessed. The Geneway HIV-1 Nucleic Acid Detection Kit from China has been successfully registered with the National Medical Products Administration. Here, we aimed to assess for the first time its detection performance.

Plasma circulating cell-free DNA integrity and relative telomere length as diagnostic biomarkers for Parkinson's disease and multiple system atrophy: a cross-sectional study.

In clinical specialties focusing on neurological disorders, there is a need for comprehensive and integrated non-invasive, sensitive, and specific testing methods. Both Parkinson's disease and multiple system atrophy are classified as α-synucleinopathies, characterized by abnormal accumulation of α-synuclein protein, which provides a shared pathological background for their comparative study. In addition, both Parkinson's disease and multiple system atrophy involve neuronal death, a process that may release circulating cell-free DNA (cfDNA) into the bloodstream, leading to specific alterations.

Ninety-Day Feeding Test of Stacked DBN9936 × DBN9501 Maize on Sprague Dawley Rats.

The transgenic maize DBN9936 × DBN9501, which confers resistance to insects and tolerance to herbicides, was developed via conventional cross breeding of transgenic maize DBN9936 and DBN9501. In our present study, a 90-day feeding toxicity study was conducted on Sprague Dawley rats to evaluate the safety of the maize. A total of 140 rats were randomly assigned to seven groups (n = 10/sex/group): one control group, three genetically modified (GM) groups with 17.

Application of nanoultrasonography in early diagnosis of coronary heart disease.

Coronary heart disease (CHD) remains one of the leading causes of mortality and disability globally. In recent years, nanoultrasonography technology has demonstrated significant potential in both the diagnosis and treatment of CHD. This review summarizes the latest research advancements in nanoultrasonography within the field of coronary heart disease, focusing on its applications in early diagnosis, targeted drug delivery, imaging techniques, and treatment strategies.

Impact of Early Ying Yang Bao Nutritional Support on Growth and Neurodevelopment in Preschool Children in China.

: Providing early nutritional support through Ying Yang Bao (YYB) can assist children in achieving their full developmental potential. We aimed to examine the lasting impact of YYB and how growth affects neurodevelopment in preschool children. : 1104 children aged 1 year were divided into a YYB control group (YYB-CG) and a YYB intervention group (YYB-IG).

A ratiometric fluorescent sensing foil for high resolution 2D pH measurement based on a novel hydroxy-pyrene green fluorophore.

The pH of environmental systems plays a crucial role in determining pollutant behavior, necessitating the development of effective tools for real-time monitoring. This study introduces a novel series of lipophilic HPTS derivatives, developed through a two-step synthesis route, designed as pH-sensitive dyes, characterized by high fluorescence intensity, photostability, dual excitation/single emission, and significant Stokes shifts. We engineered self-ratiometric pH-sensing planar optode foils and investigated the impact of carbon chain length on foil durability.

A digital manufactured microfluidic platform for flexible construction of 3D co-culture tumor model with spatiotemporal resolution.

The specific spatiotemporal distribution of diverse components in tumor microenvironment plays a crucial role in the cancer progression.three-dimensional (3D) tumor models with polydimethylsiloxane (PDMS) based microfluidic platform have been applied as useful tool to conduct studies from cancer biology to drug screening. However, PDMS has not been welcomed as a standardized commercial application for preclinical screening due to inherent limitations in scale-up production and molecule absorption.

Effect of Remimazolam- Vs Propofol-Based Intravenous Anesthesia on Surgical Stress Response and Post-Operative Immune Function in Patients with Gastric Radical Surgery.

Purpose: This study aimed to compare the impact of remimazolam-based versus propofol-based intravenous anesthesia on surgical stress and post-operative immune function in patients undergoing gastric radical surgery.

Patients And Methods: Sixty-eight patients aged 50 to 80 undergoing gastric radical surgery were randomly assigned to the remimazolam group (group R) or the propofol group (group P), receiving remimazolam or propofol-based intravenous anesthesia, respectively. The primary outcome measured was peri-operative serum stress indicators and lymphocyte subtypes.

Platelet-Rich Plasma Inhibits Breast Cancer Proliferation.

Background: Platelet-rich plasma (PRP) helps promote wound healing, but it is unclear whether it stimulates breast cancer cell proliferation, which restricts its application in breast cancer patients. This article explored the effect of PRP on breast cancer cell proliferation through preclinical experiments.

Method: We cultivated MDA-MB-231 breast cancer cells with PRP in vitro.

Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: The pCAD-POAF Randomized Clinical Trial.

Importance: Efficient approaches to prevent postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) are still needed.

Objective: To investigate whether partial cardiac denervation, achieved by cutting off the ligament of Marshall (LOM) and resecting the fat pad along the Waterston groove, can reduce the risk of POAF following CABG.

Design, Setting And Participants: This single-center, randomized clinical trial enrolled adult patients scheduled for isolated CABG in China.

AMFR-mediated Flavivirus NS2A ubiquitination subverts ER-phagy to augment viral pathogenicity.

Flaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles. However, the role of ER autophagy (ER-phagy) in viral replication process remains poorly understood. Here, we reveal that prolonged Zika virus (ZIKV) infection results from the degradation of ER-phagy receptor FAM134B, facilitated by viral NS2A protein.

Target Ligand Separation and Identification of Isoforsythiaside as a Histone Lysine-Specific Demethylase 1 Covalent Inhibitor Against Breast Cancer Metastasis.

Histone lysine-specific demethylase 1 (LSD1) is hyperactive in breast cancer, which is associated with the metastasis of the tumor. Current irreversible LSD1 inhibitors are all synthesized by covalently binding to the flavin adenine dinucleotide cofactor, which often have side effects due to the high affinity for a variety of targets. Here, we identified isoforsythiaside (IFA), a natural phenylpropanoid glycoside isolated from , as a novel covalent inhibitor of LSD1.

Accurate molecular recognition from the lowest unoccupied molecular orbital.

The quantification of the lowest unoccupied molecular orbital level (LUMO) for molecular semiconductors is of great importance, because it determines the charge transport process and hence the performances of diverse electronic devices. Unfortunately, there is always lack of a convenient technique to determine the intrinsic LUMO. This work provides a reliable electrical spectroscopy by employing an easy-operating hot electron transistor, to make an accurate measurement.