Publications by authors named "Han Byul Jung"
Article Synopsis
- - The TP53 c.359A＞G mutation creates a new splice site, disrupting normal p53 expression, but using an antisense morpholino oligomer (AMO) can fix this splicing issue, restoring normal levels of the p53 variant.
- - The corrected p53 K120R protein is shown to have weakened ability to regulate the CDKN1A gene (which helps stop cell growth) but still promotes the BBC3 gene (which triggers cell death), indicating a partial retention of tumor suppressor functions.
- - This research highlights the importance of acetylation at lysine 120 for p53's tumor-suppressing abilities and proposes that targeting mutant TP53 mRNA with AMO could be a
Background: A patient's overall condition sometimes does not allow for the complete removal of a dead eschar or injured slough in cases involving a pressure-injury skin lesion. This frequently occurs in clinical practice, particularly in bedridden and older patients receiving home care or intensive care. Even after debridement, it is also difficult to manage open exudative wounds in these patients.
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