Catheter-directed therapy for pulmonary embolism in pediatrics: a systematic review and meta-analysis.

Background: Acute pulmonary embolism (PE) is a serious and potentially fatal condition that is relatively rare in the pediatric population. In patients presenting with massive/submassive PE, catheter-directed Therapy (CDT) presents an emerging therapeutic modality by which PE can be managed.

Methods: Electronic databases were systematically searched through May 2024.

Phytol and bilimbi phytocompounds induce thermogenic adipocyte differentiation: An in vitro study on potential anti-obesity effects.

Obesity is a major health concern associated to diabetes, cardiovascular disease, and cancer. Brown adipocytes, which specialise in thermogenesis, offer a potential therapeutic target for obesity prevention and related conditions. This study builds on previous findings of the browning activity of Averrhoa bilimbi hexane fractions and aims to elucidate the underlying mechanisms in vitro.

An AI-Driven Framework for Detecting Bone Fractures in Orthopedic Therapy.

This study presents an advanced artificial intelligence-driven framework designed to enhance the speed and accuracy of bone fracture detection, addressing key limitations in traditional diagnostic approaches that rely on manual image analysis. The proposed framework integrates the YOLOv8 object detection model with a ResNet backbone to combine robust feature extraction and precise fracture classification. This combination effectively identifies and categorizes bone fractures within X-ray images, supporting reliable diagnostic outcomes.

Individual, Host-Vector Interactions, and Environmental Risk Factors for Malaria Among At-Risk Communities in Peninsular Malaysia: A Case-Control Study.

Highlighting the individual, host-vector interactions, and environmental risk factors for knowlesi malaria were consequential toward more focused and effective prevention and control strategies. This study aims to identify the individual, host-vector interactions, and environmental risk factors for Plasmodium knowlesi malaria among at-risk communities in Peninsular Malaysia. A case-control study was conducted involving laboratory-confirmed cases of P.

Uptake of lead, cadmium and copper by heavy metal-resistant Pseudomonas aeruginosa strain DR7 isolated from soil.

This study highlights the biosorption capacity for Cd (II), Cu (II) and Pb (II) by a locally isolated Pseudomonas aeruginosa DR7. At initial concentrations of 150 mg L and 240 min of contact time, P. aeruginosa DR7 showed a 62.

Use of Ni/CNT Particles as Additive Fillers in Ebonite Bipolar Plates for Proton-Exchange Membrane Fuel Cells.

Composite-based bipolar plates are a chance to substitute graphite and metal bipolar plates because of their corrosion resistance and better chemical and mechanical properties, but they still have various electrical conductivity properties. One of the problems is the loading of filler that depends on matrix types which will affect the electrical conductivity of bipolar plates; ebonite has potential as a matrix in composite bipolar plates because it is obtained from elastomer or rubber. In this work, nickel and carbon nanotubes (CNT) that have a high electrical conductivity will be investigated as additive fillers on graphite particles to enhance the electrical conductivity of ebonite bipolar plates.

Self-assessment for continuous professional development: The perspective of Islamic Education.

This study was conducted to explore the concept of self-assessment that must be practiced by Islamic education teachers for continuous professional development, focusing on the views of Islamic education teachers (IETs). Since, the researcher is trying to collect further information, it is appropriate to employ a qualitative approach in the form of a case study. Six participants were selected using purposive sampling techniques based on specific criteria.

Optimization of Exon-Skipping Riboswitches and Their Applications to Control Mammalian Cell Fate.

Mammalian riboswitches that can regulate transgene expression via RNA-small molecule interaction have promising applications in medicine and biotechnology, as they involve no protein factors that can induce immunogenic reactions and are not dependent on specially engineered promoters. However, the lack of cell-permeable and low-toxicity small molecules and cognate aptamers that can be exploited as riboswitches and the modest switching performance of mammalian riboswitches have limited their applications. In this study, we systematically optimized the design of a riboswitch that regulates exon skipping via an RNA aptamer that binds ASP2905.

Cocoa by-products: A comprehensive review on potential uses, waste management, and emerging green technologies for cocoa pod husk utilization.

Cocoa is considered to be one of the most significant agricultural commodities globally, alongside Palm Oil and Rubber. Cocoa is the primary ingredient in the manufacturing of chocolate, a globally popular food product. Approximately 30 % of cocoa, specifically cocoa nibs, are used as the primary constituent in chocolate production.

Optimization of subcritical water extraction for pectin extraction from cocoa pod husks using the response surface methodology.

This study optimized subcritical water extraction (SWE) conditions to maximize pectin yield from cocoa pod husk (CPH) and compared the characteristics of CPH pectin extracted through SWE with those of CPH pectin obtained through conventional extraction (CE) with citric acid. The Box-Behnken experimental design was employed to optimize SWE and examine the influence of process parameters, including temperature (100 °C-120 °C), extraction time (10-30 min), and solid:liquid ratio (SLR) (1:30-2:30 g/mL), on pectin yield. The maximum pectin yield of 6.

Formulation and Characterization of Intranasal Drug Delivery of Frovatriptan-Loaded Binary Ethosomes Gel for Brain Targeting.

Background: Frovatriptan succinate (FVT) is an effective medication used to treat migraines; however, available oral formulations suffer from low permeability; accordingly, several formulations of FVT were prepared.

Objective: Prepare, optimize, and evaluate FVT-BE formulation to develop enhanced intranasal binary nano-ethosome gel.‎.

Impact of pharmacist interventions on immunisation uptake: a systematic review and meta-analysis.

Background: Under-utilisation of immunisation services remains a public health challenge. Pharmacists act as facilitators and increasingly as immunisers, yet relatively little robust evidence exists of the impact elicited on patient health outcome and vaccination uptake.

Objective: To evaluate the influence of pharmacist interventions on public vaccination rate.

Skin hydration modulatory activities of Ficus deltoidea extract.

Ficus deltoidea was known for its potent antioxidant, anti-melanogenic and photoprotective skin barrier activities. These properties are contributed by its biomarkers which are vitexin and isovitexin. This study aims to optimize the yield of methanolic extraction of Ficus deltoidea leaves (EFD) and evaluate their effects on skin barrier function and hydration.

Risk Factors for Extubation Failure After Pediatric Cardiac Surgery and Impact on Outcomes: A Multicenter Analysis.

Importance: Extubation failure (EF) after pediatric cardiac surgery is associated with increased morbidity and mortality.

Objectives: We sought to describe the risk factors associated with early (< 48 hr) and late (48 hr ≤ 168 hr) EF after pediatric cardiac surgery and the clinical implications of these two types of EF.

Design Setting And Participants: Retrospective cohort study using prospectively collected clinical data for the Pediatric Cardiac Critical Care Consortium (PC4) Registry.

Bivalirudin or heparin for systemic anticoagulation during pediatric extracorporeal membrane oxygenation: Multicenter retrospective study.

Background: The objective of this study is to evaluate the outcomes of unfractionated heparin (UFH) compared to bivalirudin anticoagulation in pediatric ExtraCorporeal Membrane Oxygenation (ECMO).

Methods: A multicenter retrospective study, that included pediatric patients <18 years of age, who were supported on ECMO between June 2017 and May 2020. Patients treated with UFH were matched 2:1 by age and type of ECMO support to the bivalirudin group.

Development of adjustable variable stiffness restrainer for bridge subjected to seismic excitation.

This paper presents a numerical and experimental assessment of a developed adjustable variable stiffness restrainer (AVSR) utilized for short span bridges. This restrainer has the ability to demonstrate multi stiffness capacity in different stages of bridge's superstructure movement to mitigate the severe damage of bridge due to an earthquake. The multi-level stiffness behavior of developed AVSR is achieved by using multiple mechanical springs with different lengths and placed in parallel in proposed design.

Effect of organic loading on anaerobic digestion of cow dung: Methane production and kinetic study.

Organic loading influences the effectiveness of producing biogas through anaerobic digestion. This study set out to investigate the effect of organic loading on the anaerobic mesophilic digestion of cow dung, the parameters involved in the digestion process and to evaluate the kinetics. Anaerobic digestion of cow dung at different organic loading (gVS/L) of 14 gVS/L, 18gVS/L, 22 gVS/L, 26 gVS/L and 30 gVS/L were investigated.

A case report of an extremely rare association of ankylosing spondylitis with pachydermoperiostosis.

Key Clinical Message: We describe a case of a young man with features of pachydermoperiostosis and spondyloarthropathy. By describing this rarity, we aim to help build a database for future studies and construct a management plan that rheumatologists and clinicians can use.

Abstract: This is the first case report in Iraq describing the combination of pachydermoperiostosis and ankylosing spondylitis.

Analysis of Wholesale Drug Acquisition and Laboratory Assessment Costs Between Heparin Compared With Bivalirudin-Based Systemic Anticoagulation Strategies in Adult Extracorporeal Membrane Oxygenation.

Objectives: To assess the wholistic costs of systemic anticoagulation delivery in heparin versus bivalirudin-based maintenance of adult patients supported on extracorporeal membrane oxygenation (ECMO).

Design: Single-center retrospective cohort study.

Setting: Large academic ECMO center.

Complementary and alternative medicine for children with sickle cell disease: A systematic review.

Background: Complementary and alternative medicine (CAM) is a popular alternative to opioid and other analgesics in sickle cell disease (SCD). We review the effectiveness, prevalence, and factors associated with CAM use in the pediatric SCD population.

Methods: The review protocol was created based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

How do locus of control influence business and personal success? The mediating effects of entrepreneurial competency.

This research aims to assess the influence of locus of control on the expression of entrepreneurial competency in a small business setting. Specifically, it predicts how this can generate positive outcomes in terms of business growth, quality of life, and sustainable entrepreneurial intention. Survey responses were collected from 102 small-sized firms in Malaysia.