Publications by authors named "Hamza A Khan"

Article Synopsis
  • Wolfiporia cocos is a fungus valued for its health benefits in Traditional Chinese Medicine and shows promise for pharmaceutical and industrial use.
  • The study focused on optimizing liquid fermentation techniques to enhance mycelial biomass yield and the concentration of pachymic acid, discovering significant production increases under improved conditions.
  • Researchers also explored the genetic factors influencing this production, finding that key genes like squalene monooxygenase and glycoside hydrolases 16 were significantly expressed during the optimized fermentation process.
View Article and Find Full Text PDF

Endothelial dysfunction (ED) is a significant risk factor of blood vessel related diseases of diabetes and this study evaluate the effect of adding Momordica charantia (Mc) to glibenclamide (GLB) on ED markers in diabetic rats. Streptozotocin (STZ-40mg/kg b. w.

View Article and Find Full Text PDF
Article Synopsis
  • Hypotrichosis is a rare form of hair loss caused by mutations in the LIPH gene, leading to non-functional protein formation and resulting in brittle, coarse hair.
  • Through in silico analysis, researchers identified 9 potentially harmful non-synonymous SNPs (nsSNPs) in the LIPH gene, specifically highlighting three nsSNPs (W108R, C246S, and H248N) as significant.
  • This research lays groundwork for future studies on LIPH-related hair loss and may aid in the development of personalized medicine approaches.
View Article and Find Full Text PDF

In this article, a coding metasurface is specifically designed to switch transmission and reflection functionalities between two different frequency bands for linearly polarized waves within wide incidence angles. A metasurface consists of four metallic patterns, where the middle two structures are inserted to ensure effective performance of transmission and reflection, while the top and bottom patterns are designed based on simultaneously controlling the reflection phase for both polarization states. It has been experimentally demonstrated that the proposed metasurface can convert a transmission band into a complete reflection band (meanwhile, the reflection band is translated into a complete transmission band) by changing the incident polarization state.

View Article and Find Full Text PDF

Agro-Wastes are identified as to manufacture potential valuable organic biochar fertilizer product economically while also managing the waste. Biochar (BC) produced from agriculture waste is helps to improve the soil because of its neutral pH, addition of organic carbon to the soil and lower salt index values. This study focused on the development of nano-biochar into a more enhanced biochar product where it was checked whether the biochar derived from wheat straw can absorb nutrients and then act as support matter for releasing micro-nutrients and macro-nutrients for the plants on slow liberation basis.

View Article and Find Full Text PDF

The ongoing outbreak of coronavirus disease COVID-19 is significantly implicated by global heterogeneity in the genome organization of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The causative agents of global heterogeneity in the whole genome of SARS-CoV-2 are not well characterized due to the lack of comparative study of a large enough sample size from around the globe to reduce the standard deviation to the acceptable margin of error. To better understand the SARS-CoV-2 genome architecture, we have performed a comprehensive analysis of codon usage bias of sixty (60) strains to get a snapshot of its global heterogeneity.

View Article and Find Full Text PDF

Background Opioid analgesics, also known as narcotics, are medicinal drugs used primarily for the management of pain secondary to any type of cancer, severe injury or surgery. Due to the ease of availability, opioids are commonly abused. In 2015, reported deaths exceeded 33,000 Americans from opioid overdose.

View Article and Find Full Text PDF

Background: The prostate gland is a male sexual organ which has a number of diseases associated with it, such as prostatitis, benign prostatic hyperplasia (BPH), and prostatic cancer (PC). BPH is the most common neoplasm, and it causes significant urinary symptoms in adult males. According to the World Health Organization (WHO) report of 2014, out of all the cancers, PC had the fifth highest incidence in males throughout Pakistan.

View Article and Find Full Text PDF

Introduction TP53 mutation and overexpression have been correlated with poor survival in many cancers including oral squamous cell carcinoma (OSCC). We aim to understand the role of TP53 overexpression in OSCC in our population and correlate it with five-year survival to test its viability as a prognostic marker for OSCC patients. Materials and methods Patients with biopsy proven OSCC at Aga Khan University Hospital from January 2000 to January 2008 were recruited.

View Article and Find Full Text PDF

Hernia of Morgagni is congenital defects in the diaphragm. They are mostly asymptomatic and present with vague symptoms when they do so. A high index of suspicion is required for timely diagnose of this condition.

View Article and Find Full Text PDF

We report a 5-year boy presenting with pain in the lower chest and upper abdomen. On evaluation with computed tomography scan of the chest, he was found to have a large 16 x 14 cm posterior mediastinal mass compressing the inferior vena cava and liver, and shifting the heart to the opposite side. Tumor was approached via right postero-lateral thoracotomy and dissected off from esophagus, heart, inferior vena cava and lungs.

View Article and Find Full Text PDF

Background/aims: South Asia is an enigma for gastric cancer (GC) because it is a low risk region with a high prevalence of Helicobacter pylori (H. pylori) infections. We evaluated the trend of GC clinical presentation and risk factors in patients with dyspeptic symptoms.

View Article and Find Full Text PDF

A 28-year-old woman presented with 3-month history of fever of unknown origin and progressively increasing cough. She was diagnosed with pulmonary tuberculosis on bronchial lavage cultures. A chest X-ray performed on follow-up showed a new opacity in the left apical area of the chest.

View Article and Find Full Text PDF