Surgeon Performance as a Predictor for Patient-Reported Outcomes After Arthroscopic Partial Meniscectomy.

Background: Surgeon performance has been investigated as a factor affecting patient outcomes after orthopaedic procedures to improve transparency between patients and providers.

Purpose/hypothesis: The purpose of this study was to identify whether surgeon performance influenced patient-reported outcomes (PROMs) 1 year after arthroscopic partial meniscectomy (APM). It was hypothesized that there would be no significant difference in PROMs between patients who underwent APM from various surgeons.

Be the Change You Want to See: Intergroup Helping Reduces InGroup Bias and Facilitates OutGroup Bias in Trading Behaviors.

This research investigated how an instance of intergroup helping affects intergroup attitudes and cooperative behavior. Past research demonstrates that helping behavior elicits prosociality, both reciprocally and toward uninvolved third parties. However, much of this research has either ignored group membership altogether or has assumed a shared group identity between benefactor and beneficiary.

An International, Multidisciplinary Consensus Set of Patient-Centered Outcome Measures for Substance-Related and Addictive Disorders.

In 1990, the United States' Institute of Medicine promoted the principles of outcomes monitoring in the alcohol and other drugs treatment field to improve the evidence synthesis and quality of research. While various national outcome measures have been developed and employed, no global consensus on standard measurement has been agreed for addiction. It is thus timely to build an international consensus.

Rhesus monkeys show greater habituation to repeated computer-generated images than do orangutans.

Humans and several other species of animals have demonstrated the ability to use familiarity to recognize that they have seen images before. In prior experiments, orangutans failed to show use of familiarity in memory tasks, even when other solutions were not available. We tested for evidence of habituation, a decreased response to repeated stimuli, as a behavioral indicator that repeated images were familiar to subjects.

No evidence of real-world equivalence in chickens (Gallus gallus domesticus) categorizing visually diverse images of natural stimuli presented on LCD monitors.

Category learning is often tested with similar images that have no significance outside of the experiment for the subjects. By contrast, in nature animals often need to generalize a behavioral response like "eat" across visually distinct stimuli, such as spiders and seeds. Forming functional categories like "food" and "predator" may require conceptual rather than purely perceptual generalization.

RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes.

Treatment for type 1 diabetes (T1D) requires stimulation of functional β cell regeneration and survival under stress. Previously, we showed that inhibition of the RANKL/RANK [receptor activator of nuclear factor kappa Β (NF-κB) ligand] pathway, by osteoprotegerin and the anti-osteoporotic drug denosumab, induces rodent and human β cell proliferation. We demonstrate that the RANK pathway mediates cytokine-induced rodent and human β cell death through RANK-TRAF6 interaction and induction of NF-κB activation.

Exploring the "misfolding problem" by systematic discovery and analysis of functional-but-degraded proteins.

In both health and disease, the ubiquitin-proteasome system (UPS) degrades point mutants that retain partial function but have decreased stability compared with their wild-type counterparts. This class of UPS substrate includes routine translational errors and numerous human disease alleles, such as the most common cause of cystic fibrosis, ΔF508-CFTR. Yet, there is no systematic way to discover novel examples of these "minimally misfolded" substrates.

Ancestral Diversity: A Socioecological Account of Emotion Culture.

Cultural differences in emotion expression, experience, and regulation can cause misunderstandings with lasting effects on interpersonal, intergroup, and international relations. A full account of the factors responsible for the emergence of different cultures of emotion is therefore urgent. Here we propose that the ancestral diversity of regions of the world, determined by colonization and sometimes forced migration of humans over centuries, explains significant variation in cultures of emotion.

Expedited upskilling of intermediate care nurses to provide critical care during the COVID-19 pandemic.

Aim: Describe the strategy, efficacy and preferred mechanisms of training used to rapidly upskill intermediate care nursing staff to provide critical care during the COVID-19 pandemic.

Design: Descriptive study.

Methods: The strategy used from March through December 2020 to upskill nurses in an intermediate care unit to administer critical care upon rapid conversion of the intermediate care unit to an intensive care unit for coronavirus disease 2019 is described.

Six adult male rhesus monkeys did not learn from the choices of a conspecific shown in videos.

There is substantial evidence of group-specific behaviors in wild animals that are thought to be socially transmitted. Yet experimental studies with monkeys have reported conflicting evidence on the extent to which monkeys learn by observing their conspecifics. In this study, we tested the feasibility of using pre-recorded video demonstrations to investigate social learning from conspecifics in rhesus monkeys.

Rhesus monkeys manipulate mental images.

Humans form mental images and manipulate them in ways that mirror physical transformations of objects. Studies of nonhuman animals will inform our understanding of the evolution and distribution among species of mental imagery. Across three experiments, we found mostly converging evidence that rhesus monkeys formed and rotated mental images.

Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism.

A lack of comprehensive mapping of ganglionic inputs into the pancreas and of technology for the modulation of the activity of specific pancreatic nerves has hindered the study of how they regulate metabolic processes. Here we show that the pancreas-innervating neurons in sympathetic, parasympathetic and sensory ganglia can be mapped in detail by using tissue clearing and retrograde tracing (the tracing of neural connections from the synapse to the cell body), and that genetic payloads can be delivered via intrapancreatic injection to target sites in efferent pancreatic nerves in live mice through optimized adeno-associated viruses and neural-tissue-specific promoters. We also show that, in male mice, the targeted activation of parasympathetic cholinergic intrapancreatic ganglia and neurons doubled plasma-insulin levels and improved glucose tolerance, and that tolerance was impaired by stimulating pancreas-projecting sympathetic neurons.

Unravelling innervation of pancreatic islets.

The central and peripheral nervous systems play critical roles in regulating pancreatic islet function and glucose metabolism. Over the last century, in vitro and in vivo studies along with examination of human pancreas samples have revealed the structure of islet innervation, investigated the contribution of sympathetic, parasympathetic and sensory neural pathways to glucose control, and begun to determine how the structure and function of pancreatic nerves are disrupted in metabolic disease. Now, state-of-the art techniques such as 3D imaging of pancreatic innervation and targeted in vivo neuromodulation provide further insights into the anatomy and physiological roles of islet innervation.

Control of Attention in Rhesus Monkeys Measured Using a Flanker Task.

At least three processes determine whether information we encounter is attended to or ignored. First, attentional capture occurs when attention is drawn automatically by "bottom up" processes, to distinctive, salient, rewarding, or unexpected stimuli when they enter our sensory field. Second, "top down" attentional control can direct cognitive processing towards goal-relevant targets.

Interaction of memory systems is controlled by context in both food-storing and non-storing birds.

Animals and humans have multiple memory systems. While both black-capped chickadees (Poecile atricapillus) and dark-eyed juncos (Junco hyemalis) are under selective pressure to remember reliable long-term spatial locations (habit memory), chickadees must additionally quickly form and rapidly update spatial memory for unique cache sites (one-trial memory). We conducted a series of three experiments in which we assessed the degree to which habit and one-trial memory were expressed in both species as a function of training context.

Relationship Match: the neural underpinnings of social feedback in romantic couples.

Romantic love involves an evaluative process in which couples weigh similarities and differences that facilitates pair bonding. We investigated neural attentive processes (P3) during evaluative relationship feedback within existing romantic couples using the Relationship Match Game. This paradigm included participant-driven expectations about relationship matching and relationship feedback from an expert panel of fictive peers and their romantic partner.

Obtaining buy-in for immediate postpartum long-acting reversible contraception programs in Texas hospitals: A qualitative study.

Objective: To understand the specific ways in which champions lead efforts to obtain and sustain buy-in for immediate postpartum long-acting reversible contraception (LARC) programs.

Methods: We conducted a qualitative study with 60 semistructured interviews at 3 teaching hospitals in Texas with physicians, nurses, administrators and other staff who participated in the implementation of immediate postpartum LARC. Physicians self-identified as champions and identified other champion physicians and administrators.

Greater dependence on working memory and restricted familiarity in orangutans compared with rhesus monkeys.

The prefrontal cortex is larger than would be predicted by body size or visual cortex volume in great apes compared with monkeys. Because prefrontal cortex is critical for working memory, we hypothesized that recognition memory tests would engage working memory in orangutans more robustly than in rhesus monkeys. In contrast to working memory, the familiarity response that results from repetition of an image is less cognitively taxing and has been associated with nonfrontal brain regions.

Animal consciousness: Should a new behavioral correlate in monkeys persuade agnostics?

After human subjects learn to look away from visible cues, their attention can still be captured by cues so brief that they cause no conscious perception. A new study has found evidence that this behavior also occurs in monkeys. Is this further evidence for consciousness in a nonhuman animal?

The Path to Eldership: Results From a Contemporary Indigenous Australian Community.

Background And Objectives: Traditionally, Elders have held a unique social position within Indigenous Australian communities. This study aimed to identify the characteristics of Indigenous Elders that distinguish them from other people in their community.

Research Design And Methods: Using a community-based participatory research approach, the study was conducted in a regional Indigenous community in Southeast Queensland.

The Effects of Feeding Antibiotic on the Intestinal Microbiota of Weanling Pigs.

This study investigated the use of carbadox in the diet of nursery pigs. Ten pens of weanling piglets were assigned to 2 treatments: one containing carbadox and another without it. From days 21 to 35 of age, the first group of piglets was fed carbadox at 55 mg/kg of diet; followed by 27.

No clinically meaningful difference in 1-year patient-reported outcomes among major approaches for primary total hip arthroplasty.

Background: Debate continues around the most effective surgical approach for primary total hip arthroplasty (THA). This study's purpose was to compare 1-year patient-reported outcome measures (PROMs) of patients who underwent direct anterior (DA), transgluteal anterolateral (AL)/direct lateral (DL), and posterolateral (PL) approaches.

Methods: A prospective consecutive series of primary THA for osteoarthritis ( = 2390) were performed at 5 sites within a single institution with standardised care pathways (20 surgeons).