Vitreous levels of unbound bevacizumab and unbound vascular endothelial growth factor in two patients.

Background: Vitreous levels of unbound bevacizumab (Avastin) and unbound vascular endothelial growth factor (VEGF) were determined in two patients. Patient 1 underwent repair of an 8-day-old rhegmatogenous retinal detachment 4 weeks after a single intravitreal bevacizumab injection, and Patient 2 underwent vitreous biopsy for endophthalmitis 48 hours after a combined bevacizumab and triamcinolone injection.

Methods: The samples of vitreous fluid were analyzed for unbound bevacizumab and unbound VEGF levels using microsphere immunoassays targeted for bevacizumab and VEGF.

Spontaneous regression of choroidal metastasis from renal cell carcinoma.

Purpose: To describe a patient with choroidal metastasis from renal cell carcinoma that spontaneously regressed after nephrectomy.

Design: Interventional case report.

Method: A 48-year-old Hispanic woman presented with reduced vision in the left eye attributable to an elevated choroidal lesion and associated exudative retinal detachment.