Investigating the Function of Adult DRG Neuron Axons Using an In Vitro Microfluidic Culture System.

A critical role of the peripheral axons of nociceptors of the dorsal root ganglion (DRG) is the conduction of all-or-nothing action potentials from peripheral nerve endings to the central nervous system for the perception of noxious stimuli. Plasticity along multiple sites along the pain axis has now been widely implicated in the maladaptive changes that occur in pathological pain states such as neuropathic and inflammatory pain. Notably, increasing evidence suggests that nociceptive axons actively participate through the local expression of ion channels, receptors, and signal transduction molecules through axonal mRNA translation machinery that is independent of the soma component.

A Community Health Worker Approach for Ending the HIV Epidemic.

Introduction: In the second half of 2019, East Baton Rouge Parish, Louisiana was selected as 1 of the 3 jump-start pilot jurisdictions for the Centers for Disease Control and Prevention-funded Ending the HIV Epidemic in the U.S. Initiative.

Methods for tuning plasmonic and photonic optical resonances in high surface area porous electrodes.

Surface plasmons have found a wide range of applications in plasmonic and nanophotonic devices. The combination of plasmonics with three-dimensional photonic crystals has enormous potential for the efficient localization of light in high surface area photoelectrodes. However, the metals traditionally used for plasmonics are difficult to form into three-dimensional periodic structures and have limited optical penetration depth at operational frequencies, which limits their use in nanofabricated photonic crystal devices.

Moiré pattern of interference dislocations in condensate of indirect excitons.

Interference patterns provide direct measurement of coherent propagation of matter waves in quantum systems. Superfluidity in Bose-Einstein condensates of excitons can enable long-range ballistic exciton propagation and can lead to emerging long-scale interference patterns. Indirect excitons (IXs) are formed by electrons and holes in separated layers.

Poly(1,4-phenylene vinylene) Derivatives with Ether Substituents to Improve Polymer Solubility for Use in Organic Light-Emitting Diode Devices.

New ether-substituted poly(1,4-phenylene vinylene) (PPV) derivatives were synthesized via Horner-Emmons coupling. The structures of the monomers and the resultant oligomers were confirmed by H and C NMR spectroscopies. The molecular weights of the oligomers were characterized by gel permeation chromatography, giving the number-average and weight-average molecular weights and the corresponding polydispersity indices.

Ruthenium oxide based microelectrode arrays for in vitro and in vivo neural recording and stimulation.

We have characterized the in vitro and in vivo extracellular neural recording and stimulation properties of ruthenium oxide (RuOx) based microelectrodes. Cytotoxicity and functional neurotoxicity assays were carried out to confirm the in vitro biocompatibility of RuOx. Material extract assays, in accordance to ISO protocol "10993-5: Biological evaluation of medical devices", revealed no significant effect on neuronal cell viability or the functional activity of cortical networks.

Gold nanostructure microelectrode arrays for in vitro recording and stimulation from neuronal networks.

An ideal microelectrode array (MEA) design should include materials and structures which exhibit biocompatibility, low electrode polarization, low impedance/noise, and structural durability. Here, the fabrication of MEAs with indium tin oxide (ITO) electrodes deposited with self-similar gold nanostructures (GNS) is described. We show that fern leaf fractal-like GNS deposited on ITO electrodes are conducive for neural cell attachment and viability while reducing the interfacial impedance more than two orders of magnitude at low frequencies (100-1000 Hz) versus bare ITO.

Pancharatnam-Berry phase in condensate of indirect excitons.

The Pancharatnam-Berry phase is a geometric phase acquired over a cycle of parameters in the Hamiltonian governing the evolution of the system. Here, we report on the observation of the Pancharatnam-Berry phase in a condensate of indirect excitons (IXs) in a GaAs-coupled quantum well structure. The Pancharatnam-Berry phase is directly measured by detecting phase shifts of interference fringes in IX interference patterns.

Visualizing the bidirectional optical transfer function for near-field enhancement in waveguide coupled plasmonic transducers.

We report visualizations of the bidirectional near-field optical transfer function for a waveguide-coupled plasmonic transducer as a metrology technique essential for successful development for mass-fabricated near-field devices. Plasmonic devices have revolutionized the observation of nanoscale phenomena, enabling optical excitation and readout from nanoscale regions of fabricated devices instead of as limited by optical diffraction. Visualizations of the plasmonic transducer modes were acquired both by local near-field excitation of the antenna on the front facet of a waveguide using the focused electron beam of a scanning electron microscope as a probe of the near-field cathodoluminescence during far-field collection from the back facet of the waveguide, and by local mapping of the optical near-field for the same antenna design using scattering scanning near-field optical microscopy as a probe of the near-field optical mode density for far-field light focused into the back facet of the waveguide.

Chemically directing d-block heterometallics to nanocrystal surfaces as molecular beacons of surface structure.

Our understanding of structure and bonding in nanoscale materials is incomplete without knowledge of their surface structure. Needed are better surveying capabilities responsive not only to different atoms at the surface, but also their respective coordination environments. We report here that d-block organometallics, when placed at nanocrystal surfaces through heterometallic bonds, serve as molecular beacons broadcasting local surface structure in atomic detail.

Spin currents in a coherent exciton gas.

We report the observation of spin currents in a coherent gas of indirect excitons. The realized long-range spin currents originate from the formation of a coherent gas of bosonic pairs--a new mechanism to suppress the spin relaxation. The spin currents result in the appearance of a variety of polarization patterns, including helical patterns, four-leaf patterns, spiral patterns, bell patterns, and periodic patterns.

Spontaneous coherence in a cold exciton gas.

If bosonic particles are cooled down below the temperature of quantum degeneracy, they can spontaneously form a coherent state in which individual matter waves synchronize and combine. Spontaneous coherence of matter waves forms the basis of a number of fundamental phenomena in physics, including superconductivity, superfluidity and Bose-Einstein condensation. Spontaneous coherence is the key characteristic of condensation in momentum space.

Electrostatic conveyer for excitons.

We report on the study of indirect excitons in moving lattices-conveyers created by a set of ac voltages applied to the electrodes on the sample surface. The wavelength of this moving lattice is set by the electrode periodicity, the amplitude is controlled by the applied voltage, and the velocity is controlled by the ac frequency. We found the dynamical localization-delocalization transition for excitons in the conveyers and determined its dependence on exciton density and conveyer amplitude and velocity.

Role of dissolved salts in thermophoresis of DNA: lattice-Boltzmann-based simulations.

We use a lattice Boltzmann based Brownian dynamics simulation to investigate the dependence of DNA thermophoresis on its interaction with dissolved salts. We find the thermal diffusion coefficient D{T} depends on the molecule size, in contrast with previous simulations without electrostatics. The measured S{T} also depends on the Debye length.

Interface segregating fluoralkyl-modified polymers for high-fidelity block copolymer nanoimprint lithography.

Block copolymer (BCP) lithography is a powerful technique to write periodic arrays of nanoscale features into substrates at exceptionally high densities. In order to place these features at will on substrates, nanoimprint offers a deceptively clear path toward high throughput production: nanoimprint molds are reusable, promote graphoepitaxial alignment of BCP microdomains within their topography, and are efficiently aligned with respect to the substrate using interferometry. Unfortunately, when thin films of BCPs are subjected to thermal nanoimprint, there is an overwhelming degree of adhesion at the mold-polymer interface, which compromises the entire process.

All-optical excitonic transistor.

We demonstrate experimental proof of principle for all-optical excitonic transistors where light controls light by using excitons as an intermediate medium. The principle of operation of all-optical excitonic transistors is based on the control of exciton fluxes by light.

Trapping indirect excitons in a GaAs quantum-well structure with a diamond-shaped electrostatic trap.

We report on the principle and realization of a new trap for excitons--the diamond electrostatic trap--which uses a single electrode to create a confining potential for excitons. We also create elevated diamond traps which permit evaporative cooling of the exciton gas. We observe the collection of excitons towards the trap center with increasing exciton density.

Localization-delocalization transition of indirect excitons in lateral electrostatic lattices.

We study transport of indirect excitons in GaAs/AlGaAs coupled quantum wells in linear lattices created by laterally modulated gate voltage. The localization-delocalization transition for transport across the lattice was observed with reducing lattice amplitude or increasing exciton density. The exciton interaction energy at the transition is close to the lattice amplitude.

Indirect excitons in elevated traps.

We report on the study of indirect excitons in elevated traps. The transition from a normal to elevated trap results in the appearance of narrow lines in the emission spectrum. The density, temperature, and voltage dependences indicate that these lines correspond to the emission of individual states of indirect excitons in a disorder potential in the elevated trap.

Exciton optoelectronic transistor.

We demonstrate experimental proof of principle for an optoelectronic transistor based on the modulation of exciton flux via gate voltage. The exciton optoelectronic transistor (EXOT) implements electronic operation on photons by using excitons as intermediate media; the intensity of light emitted at the optical output is proportional to the intensity of light at the optical input and is controlled electronically by the gate. We demonstrate a contrast ratio of 30 between an on state and an off state of the EXOT and its operation at speeds greater than 1 GHz.

Photon storage with nanosecond switching in coupled quantum well nanostructures.

Photon storage with nanosecond switching was implemented with indirect excitons in coupled quantum well nanostructures. The storage and release of photons was controlled by the gate voltage pulses. The nanosecond write and readout times were much shorter than the storage time, which reached microseconds.

Coherence length of cold exciton gases in coupled quantum wells.

A Mach-Zehnder interferometer with spatial and spectral resolution was used to probe spontaneous coherence in cold exciton gases, which are implemented experimentally in the ring of indirect excitons in coupled quantum wells. A strong enhancement of the exciton coherence length is observed at temperatures below a few Kelvin. The increase of the coherence length is correlated with the macroscopic spatial ordering of excitons.

Trapping of cold excitons in quantum well structures with laser light.

Optical trapping and manipulation of neutral particles has led to a variety of experiments from stretching DNA-molecules to trapping and cooling of neutral atoms. An exciting recent outgrowth of the technique is an experimental implementation of atom Bose-Einstein condensation. In this Letter, we propose and demonstrate laser-induced trapping for a new system--a gas of excitons in quantum well structures.