Publications by authors named "Hamit Y Ellidag"
Article Synopsis
- - This study explored the levels of N-terminal proBrain natriuretic peptide (NT-proBNP) in fetuses delivered via cesarean section due to fetal distress, comparing two groups of pregnant women.
- - The research involved 140 women, with one group having elective cesarean sections and the other having emergency cesarean sections because of fetal distress, recording data on various health metrics.
- - Results indicated significant differences in NT-proBNP levels and other health indicators between the two groups, suggesting that NT-proBNP could be an important marker for identifying fetal distress, but further studies are needed to validate these findings.
Article Synopsis
- - This study explores using serum kallistatin as a potential biomarker for diagnosing tubo-ovarian abscess (TOA), suggesting that the commonly used C-reactive protein (CRP) lacks specificity.
- - The research involved 60 patients (30 controls undergoing elective surgery and 30 hospitalized with TOA) at Antalya Training and Research Hospital in Türkiye, with various health parameters analyzed through blood samples.
- - Significant differences in multiple blood markers, including serum kallistatin levels, were found between the TOA group and controls, indicating that kallistatin could effectively aid in TOA diagnosis, although larger studies are needed for validation.
Article Synopsis
- - The study investigates how obesity and diabetes (type 1 and type 2) impact testosterone levels and oxidative stress in male rats, suggesting that oxidative stress might be key in this relationship.
- - Male Sprague-Dawley rats were divided into four groups (control, obesity, T1DM, and T2DM) and given different diets and treatments to induce metabolic conditions for comparing testosterone and oxidative stress markers.
- - Results showed that testosterone levels were significantly lower in T1DM and T2DM rats compared to the control and obesity groups, with oxidative stress markers indicating higher levels of stress in diabetic rats.
Effect of ischemia-reperfusion injury on elafin levels in rat liver.
Ulus Travma Acil Cerrahi Derg
February 2024
Article Synopsis
- The study aimed to assess serum elafin levels and its impact on liver injury due to ischemia-reperfusion in rats, comparing multiple groups with varying reperfusion durations after 30 minutes of induced liver ischemia.
- Results indicated a significant decrease in elafin levels as reperfusion time increased, with corresponding increases in ischemia-modified albumin (IMA) and total oxidant status (TOS), highlighting deteriorating liver function.
- Histopathologically, a higher grade of liver injury was associated with lower elafin levels and higher levels of liver enzymes (AST, ALT), indicating a relationship between elafin levels and liver damage severity.
Article Synopsis
- The study investigates the role of angiopoietin-2 levels in COVID-19 patients and their association with the need for intensive care unit (ICU) hospitalization.
- It involved 180 patients, with 43 requiring ICU care and findings showing significantly higher angiopoietin-2 levels in those patients (p = 0.018).
- Angiopoietin-2 levels may help predict ICU hospitalization, with a specific cut-off value of 64.5 ng/L, but the sensitivity was moderate (59%) and specificity was low (42%).
Omentin-1 Levels in Hypothyroid Patients with Autoimmune Thyroiditis.
J Coll Physicians Surg Pak
August 2023
Article Synopsis
- The study aimed to assess omentin-1 levels in patients with hypothyroidism due to autoimmune thyroiditis compared to healthy controls.
- It involved 63 hypothyroid patients and 40 healthy individuals, measuring various health indicators before and after treatment with levothyroxine sodium.
- Results showed significantly lower omentin-1 levels in hypothyroid patients and a negative correlation between omentin-1 and thyroid-stimulating hormone, indicating a potential role of omentin-1 in hypothyroidism and autoimmune thyroiditis.
Article Synopsis
- The study investigated whether serum levels of Human Epididymitis Protein 4 (HE4) increase in rats with pancreatitis induced by cerulein, focusing on 24 male Sprague-Dawley rats divided into four groups.
- Results indicated significant differences in histopathological damage among the pancreatitis groups, with damage escalating alongside the cerulein dosage, while the control group showed the least damage.
- The research concluded that HE4 levels were higher in mild pancreatitis but found no correlation between HE4 levels and the severity of the condition, despite notable differences in other enzyme levels like amylase and lipase.
Article Synopsis
- - The study aimed to assess afamin levels following weight loss in obese patients who underwent laparoscopic sleeve gastrectomy and to explore its relationship with various metabolic markers such as TSH, cholesterol, and insulin levels.
- - Blood samples were collected from 43 patients before and six months after surgery to compare changes in body mass index (BMI) and other metabolic indicators.
- - Results showed a decrease in afamin levels post-surgery that was not statistically significant, but there were significant decreases in BMI, cholesterol, and insulin levels, suggesting afamin could serve as a marker for metabolic syndrome related to obesity.
Article Synopsis
- The study focused on SCUBE-1, a protein that increases in the blood during inflammation, and how its levels vary in patients with obstructive sleep apnea (OSA).
- Researchers compared serum SCUBE-1 levels in 61 severe OSA patients and 25 simple snorers, finding higher levels in the OSA group.
- After one year of continuous positive airway pressure (CPAP) therapy, SCUBE-1 levels in OSA patients significantly decreased, indicating the treatment's effectiveness.
Article Synopsis
- The study investigates the role of periostin as a potential biomarker for chronic rhinosinusitis with nasal polyps (CRSwNP) and its relationship with polyp burden and surgical outcomes.
- In a sample of 26 CRSwNP patients undergoing endoscopic surgery and 30 patients undergoing septoplasty, they measured preoperative and postoperative scores along with tissue and serum periostin levels.
- Findings showed that periostin levels were significantly higher in CRSwNP patients and correlated positively with tissue eosinophils and postoperative symptom scores, suggesting it could be useful for assessing disease severity and prognosis.
Article Synopsis
- The study aimed to explore the roles of hepcidin and paraoxonase in obstructive sleep apnea syndrome (OSAS) by analyzing 88 patients with varying severities of sleep disorders.
- The results indicated that paraoxonase levels were significantly higher in patients who only snore compared to those with mild to severe OSAS, and there was a negative correlation between paraoxonase levels and the Apnea Hypopnea Index (AHI).
- The conclusion suggests that paraoxonase could serve as a potential biomarker for OSAS, while hepcidin was not found to have significant relevance in this condition.
Article Synopsis
- The study investigates the level of SCUBE1, a biomarker that may help predict cardiovascular events in patients undergoing treatment for obstructive sleep apnea (OSA).
- A total of 129 patients participated, with 30 having simple snoring and 99 diagnosed with OSA.
- Results show that higher SCUBE1 levels in males with severe OSA were linked to lower oxygen saturation levels and significant differences between OSA severity groups, highlighting the need for future research comparing male and female responses.
Effects of methylphenidate on height, weight and blood biochemistry parameters in prepubertal boys with attention deficit hyperactivity disorder: an open label prospective study.
Scand J Child Adolesc Psychiatr Psychol
September 2021
Article Synopsis
- A study was conducted to examine the effects of methylphenidate (MPH) on the growth, weight, and blood chemistry of prepubertal boys with ADHD, with a focus on clarifying the relationship between stimulant use and growth deviations.
- Over a 6-month period, 31 boys aged between 74 to 104 months showed a significant decrease in weight z-scores, while height z-scores remained stable.
- Notable changes in blood chemistry included increases in glucose, creatinine, and 25OH-VitD levels, while alkaline phosphatase levels decreased, suggesting the need for further investigation into how growth and metabolic changes are linked during MPH treatment.
Article Synopsis
- - The study investigated the protective effects of boric acid (BA) on liver injury caused by ischemia-reperfusion (IR) after biliary blockage in female rats, comparing a control group, an IR group, and a BA-treated IR group.
- - Results showed that both IR groups experienced higher liver enzyme levels and lower albumin levels compared to the control, but the BA+IR group exhibited better antioxidant status and less total oxidant status.
- - Histopathological analysis revealed significant liver damage in the IR group, while the BA+IR group showed less severe inflammation and cellular damage, suggesting BA's potential as a protective agent in cholestatic liver injury.
Article Synopsis
- The study aimed to explore if agomelatine (AGO) can prevent damage to testicular and epididymal tissues caused by methotrexate (MTX) in rats.
- Twenty-four male Wistar albino rats were divided into three groups: a control group, an MTX-only group, and an MTX+AGO group, which received AGO after MTX.
- Results showed that MTX led to significant tissue damage, increased oxidative stress, and inflammatory responses, while AGO treatment improved these harmful effects and helped restore normal tissue conditions.
Article Synopsis
- This study aimed to assess how different intraabdominal pressure levels during laparoscopic cholecystectomy affect oxidative stress markers in patients.
- 90 healthy patients were divided into three groups based on the CO pneumoperitoneum pressure used (7 mmHg, 10 mmHg, and 13 mmHg), with blood samples taken at various stages of the procedure to measure oxidative stress indicators.
- Results showed that higher intraabdominal pressure (Group 3) significantly increased oxidative stress markers, indicating that higher pressures during surgery may lead to more oxidative stress in patients.
Circulating SCUBE1 levels in women with polycystic ovary syndrome.
Turk J Obstet Gynecol
September 2018
Article Synopsis
- The study examines the relationship between SCUBE1 levels and polycystic ovary syndrome (PCOS) in lean women, suggesting PCOS may signify an early stage of metabolic syndrome linked to cardiovascular issues.
- Researchers analyzed 90 women with PCOS and 100 healthy controls, confirming that those with PCOS had significantly higher SCUBE1 levels (5.9 ng/mL) compared to controls (4.2 ng/mL).
- Despite increased SCUBE1 levels in women with PCOS, the study found no correlation between SCUBE1 and hormonal or metabolic factors, implying its potential role as an early biomarker for future cardiovascular problems.
Article Synopsis
- * Rats were divided into three groups: a control group, an EMR-only group, and an EMR + vitamin C group, with findings showing significant increases in oxidative stress markers in the EMR-only group.
- * Results indicated that vitamin C treatment significantly reduced oxidative stress and the expression of harmful proteins (Caspase-3 and Caspase-8) in the ovaries and uterus, suggesting it may offer protective benefits against EMR-induced damage.
Background: Proton pump inhibitor (PPI) induced hypomagnesemia is a completely unexplained issue and cases are still being reported. Long-term use is the main factor, but there are a few articles stating that it may also emerge with short-term use. We aimed to evaluate the changes of serum and urine magnesium levels during shortterm high dose pantoprazol treatment.
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- Cigarette smoking (CS) causes oxidative stress that negatively impacts the female reproductive system in a rat model, leading to changes like reduced follicle numbers and tissue damage.
- In the study, female rats were divided into three groups: a control group, one exposed to CS, and one that received alpha lipoic acid (ALA) treatment after CS exposure.
- The results showed that ALA effectively reversed the harmful effects of CS, suggesting it could serve as a protective agent against oxidative damage in the reproductive organs.
Article Synopsis
- * In a sample of 4,205 individuals, it was found that women generally had lower SFer and higher HDL-C levels compared to men, while older women (ages 50-70) showed higher total cholesterol and LDL levels.
- * The study indicated a negative correlation between SFer and HDL-C, and positive correlations with total cholesterol, triglycerides, and LDL-cholesterol, suggesting that higher SFer levels may contribute to increased cardiovascular risk in postmenopausal women.
Article Synopsis
- Prolonged use of methotrexate (MTX), an antineoplastic agent, can lead to kidney damage (nephrotoxicity) and various side effects, prompting the need to find protective measures.
- In a study involving 24 male rats, three groups were tested: a control group receiving saline, an MTX group with a single dose of MTX, and an MTX + gallic acid (GA) group receiving both MTX and GA over seven days.
- Results showed significant kidney damage in the MTX group, including increased markers of oxidative stress and inflammation, while the MTX + GA group showed reduced damage, indicating that GA may protect against MTX-induced nephrotoxicity due to
Article Synopsis
- This study investigates the distribution of the Paraoxonase (PON1) enzyme phenotypes among patients with various cardiac diseases compared to healthy controls.
- A total of 300 participants were analyzed, including those undergoing coronary artery bypass grafting (CABG), heart valve disease (HVD), heart failure (HF), and ST elevation myocardial infarction (STEMI), utilizing a dual substrate method to assess PON1 activity.
- Results indicated that the high activity RR phenotype was significantly more prevalent in the cardiac disease group, especially among STEMI and HF patients, compared to healthy controls.
Article Synopsis
- The study aimed to analyze betatrophin levels in lean glucose-tolerant women with polycystic ovary syndrome (PCOS) and assess how these levels relate to various health parameters.
- Results showed that women with PCOS had significantly higher betatrophin levels compared to healthy controls, and within the PCOS group, betatrophin levels had notable correlations with hormones and metabolic markers.
- Previous research indicated beta-cell function issues in PCOS and the role of betatrophin in promoting insulin production, but this study adds unique insights into its relationship with this condition.
Article Synopsis
- The study investigates the role of kisspeptin and neurokinin B in diagnosing idiopathic central precocious puberty (ICPP) and premature thelarche (PT) in girls presenting with early breast development before age 8.
- It involved measuring hormone levels in affected girls and comparing them to healthy controls, revealing that both kisspeptin and neurokinin B levels were significantly higher in the ICPP and PT groups.
- The findings suggest that measuring basal serum neurokinin B levels can help differentiate between ICPP and PT, potentially improving diagnostic accuracy.