Trigonelline alkaloid is effective in preventing doxorubicin-induced lung damage.

Background: One of the most popular chemotherapy medications is doxorubicin (DOX), however it can have non-negligible damage. When the underlying mechanisms of damage are investigated, the most prominent pathways are oxidative stress, inflammation and apoptosis.

Aim: We investigated the NF-κB/MAPK inflammatory pathway and cellular apoptosis to determine the efficacy of trigonelline alkaloid (TRIG) in preventing DOX-induced lung injury.

Evaluating the effects of L. extract on hyperglycaemia and insulin sensitivity in experimental type 2 diabetes in rat.

Objective: The present study aimed to investigate the effects of (JR) extract on hyperglycaemia and insulin sensitivity.

Methods: Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes + (D + JR) and Diabetes + Metformin (D + M).

Results: In the D + JR group, Fasting blood glucose (FBG) levels decreased from day 14 onwards.