Long-term exposure to small-sized silica nanoparticles (SiO-NPs) induces oxidative stress and impairs reproductive performance in adult zebrafish (Danio rerio).

The widespread use of silica nanoparticles (SiO-NPs) in various industries, including chemical polishing, cosmetics, varnishes, medical, and food products, has increased the risk of their release into aquatic ecosystems. The toxic effects of small-size SiO-NPs on the reproductive performance of zebrafish (Danio rerio) have yet to be widely studied. This study aimed to investigate the impact of chronic exposure to small-sized (35 ± 6 nm) SiO-NPs on adult zebrafish through waterborne exposure to concentrations of 5 (SNP5), 10 (SNP10), 15 (SNP15), and 20 (SNP20) μg/L of SiO2-NPs for 28 days.

Thiolated methylated dimethylaminobenzyl chitosan: A novel chitosan derivative as a potential delivery vehicle.

Chitosan is a natural mucoadhesive, biodegradable, biocompatible and nontoxic polymer which has been used in pharmaceutical industry for a lot of purposes such as dissolution enhancing, absorption enhancing, sustained releasing and protein, gene or drug delivery. Two major disadvantages of chitosan are poor solubility in physiological pH and low efficiency for protein and gene delivery. In this study thiolated methylated N-(4-N,N-dimethylaminobenzyl) chitosan was prepared for the first time in order to improve the solubility and delivery properties of chitosan.