Promising therapeutic effects of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) in addressing autism spectrum disorder induced by valproic acid.

Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects various regions of the brain. Repetitive transcranial magnetic stimulation (rTMS) is a safe and non-invasive method utilized for stimulating different brain areas. Our objective is to alleviate ASD symptoms using high-frequency rTMS (HF-rTMS) in a rat model of ASD induced by valproic acid (VPA).

Reversing valproic acid-induced autism-like behaviors through a combination of low-frequency repeated transcranial magnetic stimulation and superparamagnetic iron oxide nanoparticles.

Transcranial magnetic stimulation (TMS) is a neurostimulation device used to modulate brain cortex activity. Our objective was to enhance the therapeutic effectiveness of low-frequency repeated TMS (LF-rTMS) in a rat model of autism spectrum disorder (ASD) induced by prenatal valproic acid (VPA) exposure through the injection of superparamagnetic iron oxide nanoparticles (SPIONs). For the induction of ASD, we administered prenatal VPA (600 mg/kg, I.

Anxiety, concerns and COVID-19: Cross-country perspectives from families and individuals with neurodevelopmental conditions.

Background: The COVID-19 pandemic had a major impact on the mental health and well-being of children with neurodevelopmental conditions (NDCs) and of their families worldwide. However, there is insufficient evidence to understand how different factors (e.g.

Excessive audio-visual stimulation leads to impaired social behaviour with an effect on amygdala: Early life excessive exposure to digital devices in male rats.

Today, the effect of extreme early-life exposure to digital devices is suggested as a risk factor for neurodevelopmental disorders. However, the multitude of factors that influence brain development with subsequent behavioural abnormalities have not been fully elucidated. Herein, we simulated extreme early-life exposure to digital devices in rats by audio and visual stimulation and investigated its effects on autism-related behaviours and brain structural alteration.

Cognitive Prerequisites in Development of Childhood Anxiety: An Integrative Literature Review and Thematic Analysis.

It has been suggested that cognitive development affects the emotional experience of children, including anxiety. However, an evidence review is needed to extract cognitive prerequisites that contribute to the development of anxiety in children. The purpose of the study is to explore evidence on cognitive prerequisites involved in experiencing anxiety in children.

Electrophysiological Markers of Fairness and Selfishness Revealed by a Combination of Dictator and Ultimatum Games.

Individual behavior during financial decision making is motivated by fairness, but an unanswered question from previous studies is whether particular patterns of brain activity correspond to different profiles of fairness. Event Related Potentials (ERPs) were recorded from 39 participants who played the role of allocators in a Dictator Game (DG) and responders in an Ultimatum Game (UG). Two very homogeneous groups were formed by fair and selfish individuals.

Enhanced reading abilities is modulated by faster visual spatial attention.

Research has shown improved reading following visual magnocellular training in individuals with dyslexia. Many studies have demonstrated how the magnocellular pathway controls visual spatial attention. Therefore, we have investigated the relationship between magnocellular pathway and visual spatial attention deficits in dyslexia in order to better understand how magnocellular-based interventions may help children to learn to read.

Priming Global Processing Strategy Improves the Perceptual Performance of Children with Autism Spectrum Disorders.

We investigated (1) if the perceptual integration performance is different in children with ASD in comparison with their typically developed (TD) counterparts; and (2) if activating- priming- the global processing strategy, could benefit the integration performance of children with ASD in the subsequent task. We observed that in comparison with the TD group, children with ASD had lower performance in an information integration task that required identification of illusory shapes. Additionally, we observed that priming the global processing strategy increased the correct identification of the illusory shapes in the subsequent task.

Dual Profile of Environmental Enrichment and Autistic-Like Behaviors in the Maternal Separated Model in Rats.

Background: Environmental Enrichment (EE) has been suggested as a possible therapeutic intervention for neurodevelopmental disorders such as autism. Although the benefits of this therapeutic method have been reported in some animal models and human studies, the unknown pathophysiology of autism as well as number of conflicting results, urge for further examination of the therapeutic potential of EE in autism. Therefore, the aim of this study was to examine the effects of environmental enrichment on autism-related behaviors which were induced in the maternal separation (MS) animal model.

Classifying ADHD subtypes/presentations considering the joint effect of three levels of investigation.

Aim: Discriminant validity of the Attention Deficits/Hyperactive Disorders (ADHD) subtypes/presentations is not yet clear. The purpose of this study was to investigate joint contribution of the strongest factors of the three dimensions, namely psychopathology, neuropsychology and electrophysiology for subtyping of presentations.

Method: A sample of 104 boys aged 7-12 years was subdivided into three groups with ADHD combined ( = 22), inattentive ( = 25) and hyperactive/impulsive subtype ( = 14), and 43 typically developing controls (TDC).

Early screening of autism spectrum disorder using cry features.

The increase in the number of children with autism and the importance of early autism intervention has prompted researchers to perform automatic and early autism screening. Consequently, in the present paper, a cry-based screening approach for children with Autism Spectrum Disorder (ASD) is introduced which would provide both early and automatic screening. During the study, we realized that ASD specific features are not necessarily observable in all children with ASD and in all instances collected from each child.

Brain connectivity analysis in fathers of children with autism.

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder in which changes in brain connectivity, associated with autistic-like traits in some individuals. First-degree relatives of children with autism may show mild deficits in social interaction. The present study investigates electroencephalography (EEG) brain connectivity patterns of the fathers who have children with autism while performing facial emotion labeling task.

Discrimination of ADHD Subtypes Using Decision Tree on Behavioral, Neuropsychological, and Neural Markers.

Introduction: Attention-Deficit/Hyperactivity Disorder (ADHD) is a well-known neurodevelopmental disorder. Diagnosis and treatment of ADHD can often lead to a developmental trajectory toward positive results. The present study aimed at implementing the decision tree method to recognize children with and without ADHD, as well as ADHD subtypes.

ADHD subtypes: Do they hold beyond core symptoms? A multilevel testing of an additive model.

Attention Deficit Hyperactivity Disorder (ADHD) is characterized as a behavioral syndrome with core symptoms of inattention and/or hyperactivity/impulsivity that constitute, according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), predominantly Inattentive and Hyperactive-Impulsive and a combined (additive) presentation that fulfills both criteria. The question remains if the pathophysiological background of both factors is also separate at levels of investigation beyond core symptoms. This would allow a clearer understanding and a more focused treatment approach even with tools derived from these levels.

Autistic-like behaviours and associated brain structural plasticity are modulated by oxytocin in maternally separated rats.

Background: Early psycho-social experiences influence the developing brain and possible onset of various neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD). ASD is characterized by a variety of brain abnormalities, including alteration of oxytocin receptors in the brain. Recently, early life adverse experiences, such as maternal separation (MS), have been shown to constitute risk factors for ASD in preclinical studies.

A systematic review of program circumstances in training social skills to adolescents with high-functioning autism.

Despite many programs for educating social skills to adolescents with autism, insufficient attention has been paid to examine the optimal conditions and strategies that are important for improvement and generalization of the learned skills. So after reviewing and searching for three PubMed, Scopus, and ProQuest databases, 20 studies were finally analyzed and shared conditions were extracted. The results showed that the most important condition is parental involvement.

Common elements of parent management training programs for preschool children with autism spectrum disorder.

Parent management training is a general set of interventions used as a part of a variety of clinical approaches to reduce behavioral problems of children. These behavioral problems in children with special needs (such as autism spectrum disorder) take a more complex form. The objective is to present elements, needed to develop parent management training program to reduce behavioral problems in preschool children with autism spectrum disorder.

Global precedence changes by environment: A systematic review and meta-analysis on effect of perceptual field variables on global-local visual processing.

Perceptual organization and, in particular, visual processing have been debated for many years. The global precedence effect in local-global visual processing, as introduced by David Navon, refers to the condition that global aspects of a scene are processed more rapidly than are local details. This perceptual dynamic is influenced by many factors that can be divided into two major categories: subjective or internal factors (e.

A pilot study of family-based management of behavioral excesses in young Iranian children with autism spectrum disorder.

Objective: Parent-mediated early behavioral interventions are considered as effective approaches in the treatment of children with Autism Spectrum Disorder (ASD). The majority of these interventions focus on social-communication deficits rather than behavioral excesses which severely irrupt child and family social life as well as the child's appearance behavior and learning processes. The study examines the effectiveness and feasibility of Family-based Management of Behavioral Excesses of Autism Program (FMBEAP) on Iranian families.

Behavioral and electrophysiological evidence for parent training in young children with autism symptoms and excessive screen-time.

Recent studies have shown the relationship between excessive screen time and autism symptoms. Unfortunately, there are no studies that evaluated the interventions for children with autism symptoms and excessive screen-time. This paper is a preliminary attempt to examine the effects of parent training on the duration of screen-time, repetitive behaviors and brain electrophysiological characteristics in young children with subthreshold autism symptoms and excessive screen time.

Magnocellular Based Visual Motion Training Improves Reading in Persian.

The visual magnocellular system is thought to play a crucial role in learning to read. Here therefore, we examined whether magnocellular based training could improve reading in children with visual reading problems. The participants were 24 male primary school students aged between 9-11 (Mean = 9.

Gender Classification Based on Eye Movements: A Processing Effect During Passive Face Viewing.

Studies have revealed superior face recognition skills in females, partially due to their different eye movement strategies when encoding faces. In the current study, we utilized these slight but important differences and proposed a model that estimates the gender of the viewers and classifies them into two subgroups, males and females. An eye tracker recorded participant's eye movements while they viewed images of faces.

Screening of autism based on task-free fMRI using graph theoretical approach.

Studies on autism spectrum disorder (ASD) have indicated several dysfunctions in the structure, and functional organization of the brain. However, findings have not been established as a general diagnostic tool yet. In this regard, current study proposed an automatic screening method for recognition of ASDs from healthy controls (HCs) based on their brain functional abnormalities.