Ecological risk assessment of the riverine and deltaic environments (Rozechai River, Urmia Lake, Iran), using sediment quality indices.

Rozechai River is one of the tributaries of Urmia Lake (the nrthwest of Iran), which has experienced severe pollution and water level fluctuations in the coastal zone over the past four decades. The present study aimed to assess the ecological risk for aquatic life and human health. Research methods were designed for applying the sediment quality guidelines (LEL, PEL, SEL), sediment quality indices (C, C, E, RI), and enrichment factor (EF) based on the concentration of toxic metals in sediments.

Geochemistry and ecological risk assessment of the coastal Tajan River using sediment quality indices (Southern Caspian Sea, Iran).

The present study aimed to reveal correlations between environmental events and geochemistry variation and ecological risks of the coastal Tajan River. Sediment quality indices (Cf, Cd, Er, and RI) were applied to achieve the research objectives based on the concentration of toxic metals (As, Cd, Cr, Cu, Ni, Pb, Zn). The probably effective level is based on the concentration of As, Cr, and Ni observed.

Pharmacokinetic Behavior of Phenytoin in Head Trauma and Cerebrovascular Accident Patients in an Iranian Population.

Objective: Acute brain injury is one of the leading causes of morbidity and mortality worldwide. Phenytoin has been commonly used as an anticonvulsant agent for the treatment or prophylaxis of seizures following acute brain injury. After a severe head injury, several pharmacokinetic changes occur.

Treatment of vincristine-induced ileus with metoclopramide: A case report.

Introduction: Acute lymphoblastic leukemia is an invasive malignancy which ought to be treated with several cytotoxic medications. Vincristine-based regimen is among the most commonly used regimens for the treatment of adult acute lymphoblastic leukemia. Peripheral neuropathy caused by vincristine provides a limitation in dose administration and can influence the treatment outcome and patient's quality of life.

Impact of Polymorphisms on Serum Concentration of Voriconazole in Iranian Hematological Patients.

Objective: This study aimed to determine the portion of Iranian patients who attain therapeutic serum concentrations of voriconazole (VRCZ) following administration of fixed doses. In addition, the effect of polymorphism on serum levels of VRCZ was also investigated.

Methods: Forty-eight adult patients of Iranian origin with hematologic malignancies, who received VRCZ for treatment of invasive aspergillosis, were recruited into the study.

Evaluation of the Interaction of Intravenous and Oral Voriconazole with Oral Cyclosporine in Iranian HSCT Patients.

Objective: Voriconazole as a triazole antifungal agent is widely used for prophylaxis or treatment of fungal infections in allogeneic hematopoietic stem cell transplantation (HSCT). It can increase blood concentrations of other medications including cyclosporine A (CsA) which are substrates for cytochrome P450 3A4. The aim of this study was to evaluate comparatively the interaction between oral/intravenous (IV) voriconazole and oral CsA.