l-Asparagine-EDTA-amide silica-coated MNPs: a highly efficient and nano-ordered multifunctional core-shell organocatalyst for green synthesis of 3,4-dihydropyrimidin-2(1)-one compounds.

In this study, new l-asparagine grafted on 3-aminopropyl-modified FeO@SiO core-shell magnetic nanoparticles using the EDTA linker (FeO@SiO-APTS-EDTA-asparagine) was prepared and its structures properly confirmed using different spectroscopic, microscopic and magnetic methods or techniques including FT-IR, EDX, XRD, FESEM, TEM, TGA and VSM. The FeO@SiO-APTS-EDTA-asparagine core-shell nanomaterial was found, as a highly efficient multifunctional and recoverable organocatalyst, to promote the efficient synthesis of a wide range of biologically-active 3,4-dihydropyrimidin-2(1)-one derivatives under solvent-free conditions. It was proved that FeO@SiO-APTS-EDTA-asparagine MNPs, as a catalyst having excellent thermal and magnetic stability, specific morphology and acidic sites with appropriate geometry, can activate the Biginelli reaction components.

Chitosan-EDTA-Cellulose network as a green, recyclable and multifunctional biopolymeric organocatalyst for the one-pot synthesis of 2-amino-4H-pyran derivatives.

In this research, cellulose grafted to chitosan by EDTA (Cs-EDTA-Cell) bio-based material is reported and characterized by a series of various methods and techniques such as FTIR, DRS-UV-Vis, TGA, FESEM, XRD and EDX analysis. In fact, the Cs-EDTA-Cell network is more thermally stable than pristine cellulose or chitosan. There is a plenty of both acidic and basic sites on the surface of this bio-based and biodegradable network, as a multifunctional organocatalyst, to proceed three-component synthesis of 2-amino-4H-pyran derivatives at room temperature in EtOH.