Real-world experience with nucleos(t)ide analogue therapy and patient survival rates in chronic viral hepatitis B treatment centers in Eritrea.

Real-world data on treatment outcomes or the quality of large-scale chronic hepatitis B (CHB) treatment programs in sub-Saharan Africa (SSA) is extremely difficult to obtain. In this study, we aimed to provide data on the prevalence and incidence of mortality, loss to follow-up (LFTU), and their associated factors in patients with CHB in three treatment centres in Eritrea. Additional information includes baseline clinical profiles of CHB patients initiated on nucleos(t)ide analogue (NUCs) along with a comparison of treatment with Tenofovir disoproxil fumarate (TDF) vs.

Effect of different configurations of hybrid nano additives blended with biodiesel on CI engine performance and emissions.

The use of nano additives to improve the cold properties of biodiesel is encouraged by its drawbacks and incompatibility in cold climate. Waste cooking oil (WCO) was transesterified to create biodiesel. A 20% by volume was used for combination of diesel and methyl ester.

High Incidence of Esophageal Cancer in Women in Eritrea and Its Potential Link to Low Age at Menopause: Evidence from a 10-Year Retrospective Data Analysis.

Background: Detecting a group of esophageal cancer (EC) cases in endemic regions is essential in identifying high-risk populations and executing appropriate interventions. The main aim of this study was to determine the epidemiology of EC in Eritrea.

Methods: A retrospective (period: 2011 - 2021) study was carried out by abstracting data on EC patients from the logbook kept at the National Health Laboratory (ENHL).

Antimicrobial Resistance Patterns in Patients with Vaginal Discharge: A 2019-2022 Analysis at the National Health Laboratory in Eritrea.

Background: Antimicrobial resistance poses a significant global threat to the treatment of bacterial infections, particularly in low- and middle-income regions such as Africa. This study is aimed at analyzing antimicrobial resistance patterns in vaginal swab samples from patients at the National Health Laboratory from 2019 to 2022.

Methods: This retrospective study examined patient records from vaginal swab analyses performed at the National Health Laboratory between January 1, 2019, and December 31, 2022.

Fournier's gangrene revealing an acute arterial occlusion: A case report.

Introduction And Importance: Fournier gangrene (FG) is a rare form of necrotizing fasciitis that affects both the deep and superficial layers of the perineal genital region. When left untreated, Fournier gangrene can rapidly advance, leading to substantial morbidity and mortality. Herein, we present a case of Fournier's gangrene, which revealed acute arterial occlusion.

Euler implicit time-discretization of multivariable sliding-mode controllers.

This paper aims to develop the Euler implicit time-discretization of multivariable sliding-mode controllers to solve the numerical chattering problem without modifying the continuous-time control law. To this end, a continuous-time multi-input plant under a multivariable sliding-mode control is studied, and it is shown that the implicit discretization of the continuous-time sliding-mode controller leads to a multivariable generalized equation with several set-valued terms which is not possible to be solved using the graphical interpretations. Subsequently, an algorithm is proposed to solve such a multivariable generalized equation required to synthesize the implicit sliding-mode control signal at each time step.

Real-world treatment outcome of direct-acting antivirals and patient survival rates in chronic hepatitis C virus infection in Eritrea.

Reliable real-world data on direct acting anti-retroviral (DAA) uptake and treatment outcomes are lacking for patients with hepatitis C virus (HCV) in sub-Saharan Africa. This study provides data on HCV DAA-based treatment outcomes, mortality, loss-to-follow up, and associated factors among patients in Eritrea. A multicenter retrospective observational cohort study was conducted in two tertiary hospitals in Asmara, Eritrea.

Epidemiology of confirmed measles virus cases, surveillance, incidence, and associated factors in Eritrea: 18-year retrospective analysis.

Background: Despite the outstanding measles vaccine coverage (MVC) in Eritrea, sporadic outbreaks are not uncommon. Therefore, understanding the incidence of laboratory-confirmed measles virus cases, related factors, and spatial inequalities in testing and surveillance remains crucial. In this analysis, we evaluated the incidence and spatiotemporal distribution of measles in Eritrea.

Assessment of heat transfer and the consequences of iron oxide (FeO) nanoparticles on flow of blood in an abdominal aortic aneurysm.

The present study is established on a simulation using CFD analysis in COMSOL. Blood acted as the base fluid with this simulation. The taken flow is been modeled as incompressible, unsteady, laminar and Newtonian fluid, which is appropriate at high rates of shear.

Mathematical inspection of heat transfer and unsteady viscous flow in a tunnel with trapezoidal shaped slender wall.

An exploration is made to investigate numerically and theoretically the time dependent flow of blood along with heat transfer through abnormal artery having trapezoidal shaped plaque. The flow is taken to be Newtonian, laminar, unsteady and incompressible. A suitable geometrical model is constructed to simulate the trapezoidal stenosis affected artery.

Adaptive sensorless control for interior permanent magnet synchronious motor based on sliding mode approach.

This paper proposes an adaptive sensorless control based on sliding mode approach for Interior Permanent Magnet Synchronous Motor (IPMSM) using the method of the angular position estimation error extraction. The proposed strategy combines a novel Adaptive Super-Twisting Controller (ASTWC) with a novel Adaptive Observer High-Order Sliding Mode (AOHOSM), where: (i) The control and observer gains are parameterized in terms of a single parameter simplifying its implementation and reducing the tuning time. (ii) By using an auxiliary system, which does not depend on machine parameters, an AOHOSM is designed for estimating the angular position, speed and acceleration in a wide speed range of the IPMSM, (iii) and these are used in an ASTWC to track a desired reference of speed and direct-axis current.

Reynolds nano fluid model for Casson fluid flow conveying exponential nanoparticles through a slandering sheet.

Nanofluids with their augmented thermal characteristics exhibit numerous implementations in engineering and industrial fields such as heat exchangers, microelectronics, chiller, pharmaceutical procedures, etc. Due to such properties of nanofluids, a mathematical model of non-Newtonian Casson nanofluid is analyzed in this current study to explore the steady flow mechanism with the contribution of water-based Aluminum oxide nanoparticles. A stretchable surface incorporating variable thickness is considered to be the source of the concerning fluid flow in two-dimension.

The Presence of Antineutrophil Cytoplasmic Antibodies and Antiphospholipid Antibodies in Patients with Severe Acute Respiratory Syndrome Coronavirus 2: A Case-Control Study among Sudanese Patients.

Patients infected with COVID-19 are at an increased risk for thrombosis, suggesting a possible role of COVID-19 in the induction of coagulopathy. This study aimed to investigate the presence of prothrombotic antineutrophil cytoplasmic antibodies (ANCA) and antiphospholipid antibodies (aPLs) in the course of COVID-19 infection and to correlate these markers with severity and fatality, suggesting that COVID-19-induced autoimmune thrombosis is a possible axis in the inflammatory circuit of this infection. To investigate this, we conducted a case-control study which included patients with a positive reverse transcription-polymerase chain reaction (RT-PCR) test of COVID-19 and a control group with negative COVID-19 PCR and antibody (IgG-IgM and IgA nucleoprotein) ELISA results.

Attrition and associated factors among children living with HIV at a tertiary hospital in Eritrea: a retrospective cohort analysis.

Background: Reducing attrition in paediatric HIV-positive patients using combined antiretroviral therapy (cART) programmes in sub-Saharan Africa is a challenge. This study explored the rates and predictors of attrition in children started on cART in Asmara, Eritrea.

Methods: This was a retrospective cohort study using data from all paediatric patients on cART between 2005 and 2020, conducted at the Orotta National Referral and Teaching Hospital.

Development of an in-house quantitative ELISA for the evaluation of different Covid-19 vaccines in humans.

Reliable serological assays are needed to understand the real impact of COVID-19. In order to compare the efficiency of different COVID-19 vaccines used in the National Vaccination Program in Tunisia, we have developed a quantitative in-house ELISA. The ELISA is based on the ectodomain of the SARS-CoV-2 Spike Baculovirus recombinant protein.

Optimization of fins arrangements for the square light emitting diode (LED) cooling through nanofluid-filled microchannel.

In current paper, a finned micro-channel is designed for the cooling application in Light Emitting Diode (LED), numerically using Galerkin weighted residual Finite Element Method (GFEM). Selected materials for LED-chip is GaN, Die from Si, Die-attach is made by Au-20Sn, substrate is copper and heat sink material is considered to be Al. To make a convection heat transfer for cooling process, AlO-water nanofluid is used as the cooling fluid flow through the micro-channel and tried to maximize the heat transfer efficiency by optimized geometry.

Prevalence of hepatitis B virus genotypes among patients with liver disease in Eritrea.

Eritrea is an East African multiethnic country with an intermediate endemicity for hepatitis B. Our aim was to establish the most prevalent genotypes of hepatitis B virus (HBV) among patients with liver disease. A total of 293 Eritrean patients with liver disease who were hepatitis B surface antigen (HBsAg) positive were enrolled.

Prevalence of chronic hepatitis B phases in Eritrean patients: a laboratory-based cross-sectional study.

Background: Understanding the natural history of chronic hepatitis B (CHB) virus infection is important for determining optimal management and predicting prognosis in patients. The aim of this study was to determine the prevalence of different phases of CHB infection among Eritrean patients and to identify the proportion of patients who are eligible for treatment according to the latest American Association for the Study of Liver Diseases (AASLD) guidelines.

Methods: This cross-sectional study enrolled 293 CHB patients (213 males and 80 females) between Jan 2017 and Feb 2019.

Magnitude of Multidrug Resistance among Bacterial Isolates from Surgical Site Infections in Two National Referral Hospitals in Asmara, Eritrea.

Background: The World Health Organization has emphasized the importance of understanding the epidemiology of MDR organisms from a local standpoint. Here, we report on a spectrum of bacteria associated with surgical site infections in two referral hospitals in Eritrea and the associated antibiotic susceptibility patterns.

Methods: This survey was conducted between February and June 2017.

Clinical and molecular characterization of the R751L-CFTR mutation.

Cystic fibrosis (CF) arises from mutations in the CF transmembrane conductance regulator () gene, resulting in progressive and life-limiting respiratory disease. R751L is a rare CFTR mutation that is poorly characterized. Our aims were to describe the clinical and molecular phenotypes associated with R751L.

Tuberculosis of the cervical spine.

Tuberculosis of the cervical spine is a rare extra-pulmonary localization. We reported the case of a 59-year-old woman with no medical history. She consulted for a 9 weeks history of painful cervical stiffness.

[Emergencies and humanitarian aid in cases of armed conflict].

The Libyan revolution which began in February 2011 caused a massive influx of refugees of different nationalities into Tunisia. A refugee camp was gradually set up by the Tunisian authorities in collaboration with civil society and international humanitarian organisations. The refugees' health care and emergency treatment became a necessity.

Long-pulsed Nd:YAG laser in the treatment of facial hypertrichosis during topical minoxidil therapy.

Hypertrichosis is a well-recognized adverse effect of therapy with either oral or topical minoxidil. We report a case of fronto-temporal hypertrichosis occurring in an 8-year-old girl treated for patchy alopecia areata of the frontal area of the scalp with 2% minoxidil solution. After failure of 5-months minoxidil-discontinuation, hair removal with Nd:YAG laser (1064 nm line) (Smartepil II, Deka) was tested leading to complete resolution within 2 sessions.