Synopsis of recent research by authors named "Hamid Shirani"
- Hamid Shirani's recent research focuses on the development and application of thiophene-based ligands for the detection of distinct pathological markers associated with Alzheimer's disease, particularly targeting amyloid-β (Aβ) and tau aggregates, which are crucial in neurodegeneration.
- His studies have introduced innovative methods, such as dual-staining protocols and high-resolution light-sheet imaging, to visualize and differentiate various protein aggregates in Alzheimer's disease, enhancing the understanding of their implications on disease progression.
- Additionally, Shirani's work includes examining mitochondrial oxidative stress related to Aβ aggregates in vivo, offering insights into the mechanisms of neurotoxicity and potential therapeutic strategies for ameliorating neurodegenerative conditions.
