Downregulation of Cancer-Associated lncRNAs in Peripheral Blood of Multiple Sclerosis Patients.

Recent studies have shown contribution of long non-coding RNAs (lncRNAs) in the pathogenesis of immune-related disorders including multiple sclerosis (MS). Based on the role of these transcripts in the regulation of immune response, peripheral levels of lncRNAs can reflect the level of immune activation. In the present study, we quantified expression of four lncRNAs namely SPRY4-IT1, HOXA-AS2, LINC-ROR, and MEG3 in venous blood of MS patients and controls using quantitative real-time PCR method.

Identification of HLA-A/B/DRB1 alleles in Iranian patients with Fanconi anemia.

Fanconi anemia includes a number of clinically and genetically diverse disorders all of them being associated with genomic instability. Some previous studies reported higher frequencies of certain HLA alleles in patients with Fanconi anemia. In the current study, we genotyped HLA-A/B/DRB1 alleles in 40 Iranian patients with Fanconi anemia.

Expression Levels of lncRNAs in the Patients with the Renal Transplant Rejection.

Purpose: Long non-coding RNAs (lncRNAs) include a vast portion of human transcripts. They exert regulatory roles in immune responses and participate in diverse biological functions. Recent studies indicated dysregulation of lncRNAs in the process of transplant rejection.

ANRIL Variants Are Associated with Risk of Neuropsychiatric Conditions.

The antisense non-coding RNA in the INK4 locus (ANRIL) is a long non-coding RNA (lncRNA) whose contribution in several human disorders has been verified. In the current projects, we genotyped two single nucleotide polymorphisms (SNPs) in this lncRNA (rs1333045 and rs1333048) in a population of Iranian patients with bipolar disorder (BP), major depressive disorder (MDD), and methamphetamine addiction. The rs1333045 was associated with methamphetamine addiction in recessive and multiplicative models (OR (95% CI) = 1.

IFNG/IFNG-AS1 expression level balance: implications for autism spectrum disorder.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with different epidemiological, genetic, epigenetic, and environmental factors. Although its etiology is not fully understood, immune dysfunction is implicated in this disease. Recently, a large number of genes encoding long noncoding RNAs (lncRNAs) were discovered which act as positive or negative regulators of neighboring target genes.

Epilepsy Is Associated With Dysregulation of Long Non-coding RNAs in the Peripheral Blood.

Long non-coding RNAs (lncRNAs) are a group of functional transcripts that are not translated to proteins. Recent investigations have underscored their role in the pathogenesis of neurodevelopmental disorders. In the current investigation, we quantified expression levels of four lncRNAs (, and ) in peripheral blood of epileptic patients and normal controls.

Association between HLA alleles and risk of celiac disease in Iranian patients.

Celiac disease (CD) is a common autoimmune disease that is manifested by inflammation of the small intestine and varying extra intestinal symptoms, also considered to be associated with human HLA-DQ genes. In this study, 40 patients of CD and 40 healthy control samples were genotyped for HLA-DQB1 and 14 patients of CD and 14 healthy control samples were genotyped for HLA-DQA1genes using the SSP-PCR technique and a commercial kit.The DQA1*05 allele had the highest frequency among the patient group (42.

Sex-specific up-regulation of lncRNAs in peripheral blood of patients with schizophrenia.

Schizophrenia as a common disabling psychiatric disorder has been associated with dysregulation of several genes and pathways among them are those being regulated by long non-coding RNAs (lncRNAs). Based on the acknowledged roles of lncRNAs in neurodevelopment, in the current study, we assessed expression of six lncRNAs namely HOXA-AS2, Linc-ROR, MALAT1, MEG3, SPRY4-IT1 and UCA1 in peripheral blood of 60 patients with schizophrenia and 60 healthy subjects. HOXA-AS2, Linc-ROR, MEG3, SPRY4-IT1 and UCA1 levels were significantly higher in total patients compared with total controls.

The Expression of and Long Non-coding RNAs in Lung Cancer.

Background: Long non-coding RNAs (lncRNAs) have been considered to be prospective biomarkers for diagnosing lung cancer due to the fundamental roles they hold in the regulating several cancer-related pathways.

Methods: Using the quantitative real-time polymerase chain reaction method, we evaluated the expression of and lncRNAs in 32 lung cancer tissue samples and their corresponding adjacent non-cancerous tissues (ANCTs) from lung cancer patients admitted to the Labbafi-Nejad Hospital from 2015 to 2016.

Results: No significant differences were found in the expression of lncRNAs within the tumoral and non-tumoral tissue samples.

Peripheral expression of long non-coding RNAs in bipolar patients.

Background: Long non-coding RNAs (lncRNAs) have established roles in the pathogenesis of diverse human disorders including neuropsychiatric disorders.

Methods: In the current study, we evaluated expression levels of six apoptosis-related lncRNAs (CCAT2, TUG1, PANDA, NEAT1, FAS-AS1 and OIP5-AS1) in the peripheral blood of bipolar disorder (BD) patients and healthy subjects to assess their contribution in the pathogenesis of BD.

Results: CCAT2, TUG1 and PANDA were up-regulated in total BD patients compared with total healthy subjects (P values = 0.

GRM7 polymorphisms and risk of schizophrenia in Iranian population.

The role of metabotropic glutamate receptors in the pathogenesis of schizophrenia or response to antipsychotic treatment has been proposed previously. The aim of the current study was to investigate the associations between two intronic variants within GRM7 gene (rs6782011 and rs779867) and schizophrenia in Iranian population. These two single nucleotide polymorphisms (SNPs) were genotyped in 273 schizophrenic patients and 300 age and sex-matched normal controls.

Aberrant Expression of Long Non-coding RNAs in Peripheral Blood of Autistic Patients.

Long non-coding RNAs (lncRNAs) constitute a large proportion of human transcriptome and are involved in fundamental aspects of neurodevelopment. In the present study, we evaluated expression levels of three lncRNAs, namely, Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), p21-associated ncRNA DNA damage-activated (PANDA), and taurine-upregulated gene 1 (TUG1), in peripheral blood of autism spectrum disorder (ASD) patients compared with those in healthy subjects. We found a significant upregulation of NEAT1 and TUG1 in ASD patients.

Application of the speckle-based phase retrieval method in reconstructing two unknown interfering wavefronts.

We numerically demonstrate a novel method to simultaneously reconstruct two unknown interfering wavefronts. The speckle-based phase retrieval technique is applied to derive the interference field. The derived interference field along with the phase-shifting concept is used for calculating the interfering wavefronts.

Detection and characterization of an optical vortex by the branch point potential method: analytical and simulation results.

Singularities are discontinuities in optical wavefronts that can be produced by turbulence effects. Since the presence of singularities in a wavefront severely degrades the adaptive optics correction performance, their detection is very important. The gradient of the wavefront phase, as measured by the Shack-Hartmann wavefront sensor in the presence of singularities, can be considered as the sum of the rotational and irrotational parts.

Application of the transport of intensity equation in determination of nonlinear refractive index.

We investigate the determination of nonlinear refractive index n(2), based on solving the transport of intensity equation (TIE) in conjunction with a pump-probe technique. As the pump and probe beams propagate through a sample, the pump-induced refractive index variations in the sample change the phase distribution of the probe beam. Using two recorded probe intensities in TIE, this phase change is derived, and so the nonlinear refractive index n(2) is obtained.

Reconstruction of two interfering wavefronts using Zernike polynomials and stochastic parallel gradient descent algorithm.

We numerically and experimentally demonstrate an iterative method to simultaneously reconstruct two unknown interfering wavefronts. A three-dimensional interference pattern is analyzed and then Zernike polynomials and the stochastic parallel gradient descent algorithm are used to expand and calculate wavefronts.

Very low resistance ZnS/Ag/ZnS/Ag/ZnS nano-multilayer anode for organic light emitting diodes applications.

In this paper, design and simulation of conductive nanometric multilayer systems are discussed and optimum thickness of Ag and ZnS layers are calculated to reach simultaneously to high transmittance and low sheet resistance. The conductive transparent ZnS/Ag/ZnS/Ag/ZnS (ZAZAZ) nanometric multilayer systems are deposited on glass substrates at room temperature by a thermal evaporation method. The electrical, optical, and structural properties of these multilayers, such as sheet resistance, optical transmittance, and the root-mean-square surface roughness are obtained.

Theoretical and experimental investigation of generating pulsed Bessel-Gauss beams by using an axicon-based resonator.

Nondiffracting Bessel-Gauss beams are assumed as the superposition of infinite numbers of Gaussian beams whose wave vectors lie on a cone. Based on such a description, different methods are suggested to generate these fields. In this paper, we followed an active scheme to generate these beams.

Generation of pulsed Bessel-Gauss beams using passive axicon-theoretical and experimental studies.

We studied the conditions for generating passive Bessel-Gauss beams by using an axicon. We designed an appropriate Gaussian resonator and extracted a quasi-fundamental Gaussian mode from a pulsed Nd:YAG laser pumped by a Xenon flash lamp and measured its parameters, such as propagation factor, divergence angle, and Rayleigh range. Then we generated passive Bessel-Gauss beams using an axicon and investigated their propagation properties, theoretically and experimentally.

Subjective evaluation of intraocular lenses by visual acuity measurement using adaptive optics.

We present a new method for subjectively evaluating intraocular lenses (IOLs) without implantation surgery. To illustrate the method, three types of single-piece IOL (equispherical monofocal, rotational symmetric aspheric monofocal, and diffractive bifocal) were assembled into a model eye and evaluated using an ocular adaptive optics system by a single subject. To separate the spherical aberration of the crystalline lens, the subject's corneal topography and wavefront aberrations were measured and modeled.

MTF of compound eye.

Compound eye is a new field of research about miniaturizing imaging systems. We for the first time introduce a dual compound eye that contains three micro lens arrays with aspheric surfaces. The designed dual compound eye in one state is a superposition system in which each channel images all of field of view of the system.