Publications by authors named "Hamid Askari"
Article Synopsis
- Stroke is a serious neurological disorder, with ischemic strokes making up about 80% of cases, and the main treatments are thrombolysis and thrombectomy, which don’t always lead to full recovery for patients.
- There is growing interest in stem cell therapy, particularly using induced pluripotent stem cells (iPSCs), for promoting brain repair and regeneration, but challenges like tumor formation and immune rejection complicate their use.
- The study also explores cell-free therapies like exosomes and microvesicles as promising alternatives to iPSC treatment, aiming to address the limitations faced by direct stem cell therapies.
Introduction/objective: Multiple sclerosis (MS), is characterized by autoimmune-driven neuroinflammation, axonal degeneration, and demyelination. This study aimed to explore the therapeutic potential of targeting Notch signaling within the central nervous system (CNS) in the context of MS. Understanding the intricate roles of Notch signaling could pave the way for targeted interventions to mitigate MS progression.
View Article and Find Full Text PDFCurrent Insights into the Neurotoxicity of Melamine: A Comprehensive Review.
Curr Neuropharmacol
October 2024
Article Synopsis
- * Research has primarily focused on melamine's harmful effects on kidney function, but recent studies indicate it may also negatively impact the central nervous system, causing cognitive issues and other neurological problems.
- * This review aims to explore melamine's potential neurological effects and mechanisms of toxicity, while also discussing the body's possible defenses against melamine accumulation.
Multiple sclerosis (MS) is a chronic central nervous system (CNS) disorder characterized by demyelination, neuronal damage, and oligodendrocyte depletion. Reliable biomarkers are essential for early diagnosis and disease management. Emerging research highlights the role of mitochondrial dysfunction and oxidative stress in CNS disorders, including MS, in which mitochondria are central to the degenerative process.
View Article and Find Full Text PDFUnderstanding the transmission pathways of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will aid in developing effective therapies directed at the virus's life cycle or its side effects. While severe respiratory distress is the most common symptom of a coronavirus 2019 (COVID-19) infection, the virus is also known to cause damage to almost every major organ and system in the body. However, it is not obvious whether pathological changes in extra-respiratory organs are caused by direct infection, indirect, or combination of these effects.
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