Publications by authors named "Hames Kiyomi Yamada"
Article Synopsis
- Intraoperative neurophysiological monitoring (IONM) helps prevent damage to the recurrent laryngeal nerve (RLN) during thyroid surgeries, with loss of signal (LOS) indicating potential nerve injury.
- A study of 1,442 patients documented significant differences in recovery based on the type of LOS, revealing that 74.2% of LOS in benign tumors were global type, while cancer patients more often experienced segmental type paralysis.
- Postoperative outcomes showed that patients with global LOS had better recovery rates and lower vocal cord dysfunction compared to those with segmental LOS, particularly in cancer cases where segmental LOS led to a significantly higher rate of vocal cord issues at 6 months.
Purposes: To establish the appropriate staging system and assess the role of curative thyroidectomy alone (Surgery) vs. involved-site radiation therapy after open biopsy (OB-ISRT) in stage IE mucosa-associated lymphoid tissue (MALT) lymphoma.
Methods: We examined the Tokyo Classification as a modified classification.
Article Synopsis
- Age is an important factor in determining treatment strategies for papillary thyroid cancer (PTC), which are often based primarily on disease progression.
- This study analyzed data from 837 patients and found that age, along with extrathyroidal extension and the number of metastatic lymph nodes, significantly affects disease-specific survival and distant metastasis-free survival.
- The findings suggest that younger patients without extrathyroidal extension can avoid aggressive treatment, while older patients with this condition may require more intensive therapies.
Article Synopsis
- - The study assessed the effectiveness of paclitaxel as a neoadjuvant treatment for patients with anaplastic thyroid carcinoma (ATC) and examined factors affecting overall survival (OS) and response to the drug.
- - Results showed that patients who underwent surgical resection after paclitaxel treatment had a significantly longer median OS (14.7 months) compared to those who didn't have surgery (4.2 months).
- - Key independent prognostic factors for OS included a prognostic index (PI) of 2 or higher, positive response to paclitaxel, the ability to undergo resection, and prior radiotherapy, though no baseline characteristics predicted response to paclitaxel.
Background: Previous studies have reported an association between four or more foci of vascular invasion (VI) and thyroid cancer prognosis, while the current study aimed to investigate the association between extent of VI and outcome of encapsulated angioinvasive follicular thyroid carcinoma (FTC).
Methods: The records of 303 patients with encapsulated angioinvasive FTC confirmed by surgical specimens at Ito Hospital from January 2005 to December 2014 were retrospectively reviewed. Thirteen patients had distant metastasis at diagnosis and were classified as M1.
Purpose: There is no sufficient data about the clinical course and outcome in thyroid cancer patients who become pregnant after diagnosis of distant metastasis (DM). The current study was conducted to collect information regarding the clinical and reproductive characteristics, and outcomes in thyroid cancer patients who became pregnant after being diagnosed with DM.
Methods: Records of 125 differentiated thyroid cancer (DTC) patients with age ≤45 years at DM diagnosis who had visited Ito Hospital from January 2005 to June 2021 were retrospectively reviewed.
The characteristics of pediatric differentiated thyroid cancer (DTC) are substantially different from those of adult DTC. This study investigated whether the cutoff age of 18 years, as recommended by the American Thyroid Association (ATA) management guidelines for pediatric DTC, is appropriate based on clinical characteristics and outcomes. The medical records of 288 patients aged <21 years with DTC, who underwent initial surgery between 1979 and 2014, were retrospectively reviewed.
View Article and Find Full Text PDFContext: The specific characteristics of pediatric and adolescent differentiated thyroid cancer (DTC) is the more frequent occurrence of distant metastasis (DM) compared with adult DTC.
Objective: To investigate the clinical outcomes of DM in this population and analyze risk factors related to DM.
Design, Setting, And Participants: Medical records of 171 patients with DTC < 19 years old, who underwent initial surgery between 1979 and 2014 were retrospectively reviewed.
Article Synopsis
- Radioactive iodine (RAI) therapy is typically used for treating papillary thyroid carcinoma (PTC) patients with distant metastasis (DM), but its effectiveness remains uncertain against more recent treatments like tyrosine kinase inhibitors (TKIs).
- A study involving 64 PTC patients treated solely with RAI therapy revealed 10, 15, and 20-year survival rates of 68.2%, 63.6%, and 61.1%, highlighting the long-term risks associated with the disease.
- Key risk factors linked to increased mortality included age over 55, metastasis outside the lungs, and lack of RAI avidity, with specific combinations of these factors significantly raising mortality expectations in patients.
Electrical activation of the myocardium to produce effective pumping of blood depends on the orderly coordinated spatial and temporal transfer of current from one cell to another via gap junctions. Normal ventricular myocytes are extensively coupled by gap junctions and have the capacity to rapidly increase the amount of connexin within gap junction plaques to meet physiological demands for enhanced cell-cell communication. However, myocytes can also rapidly uncouple in response to injury or disease.
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