Protective effects of Euphorbia heterophylla against testicular degeneration in streptozotocin-induced diabetic rats in relation to phytochemical profile.

Background: Diabetes mellitus (DM) poses a major risk to human health due to an array of implications, one of which is a detrimental effect on the testicular and reproductive functions. Euphorbia heterophylla is widely recognized for its medicinal properties worldwide.

Methods And Findings: The objective of this study was to profile E.

Simultaneous Detection of Hydrogen Sulfide and Peroxynitrite Dysregulation with a Sequentially Activated Fluorescent Probe in Ulcerative Colitis Disease.

Ulcerative colitis (UC), often referred to as "green cancer", is a chronic inflammatory bowel disease with an unclear etiology, closely associated with the imbalance of hydrogen sulfide (HS) and peroxynitrite (ONOO). HS exhibits anti-inflammatory effects at physiological levels, but excessive concentrations can compromise the intestinal barrier, while ONOO aggravates inflammation. To facilitate the molecular-level monitoring of these compounds in UC, we developed a novel fluorescent probe, , capable of simultaneously detecting HS and ONOO via distinct fluorescent channels in a cascade mode.

An Overview of Zika Virus and Zika Virus Induced Neuropathies.

Flaviviruses pose a major public health concern across the globe. Among them, Zika virus (ZIKV) is an emerging and reemerging arthropod-borne flavivirus that has become a major international public health problem following multiple large outbreaks over the past two decades. The majority of infections caused by ZIKV exhibit mild symptoms.

Personality and Attachment Patterns in Patients with Psychogenic Non-Epileptic Seizures in Saudi Arabia.

The purpose of this study was to investigate personality and relationship patterns in patients with psychogenic non-epileptic seizures (PNES) and compare them to patients with epilepsy and healthy controls. A total of 68 participants were recruited (mean age = 29.8 ± 9.

G-tube contrast check: Transition from fluoroscopy to abdominal radiographs.

Reports of radiographic exam evaluation for G-tube malposition in children are limited. Evaluate effectiveness of a new 2-view abdominal radiograph exam protocol instituted to provide 24/7 coverage at 2 affiliated hospitals and replace the prior fluoroscopic G-tube contrast check exam. G-tube radiographic exams performed between December 2019 and May 2022 at 2 affiliated hospitals were identified and retrospective chart review was performed to delineate exam test yield, accuracy, sensitivity, specificity.

A bifunctional naphthalimide-based fluorescent probe for imaging lysosomal peroxynitrite and viscosity in living cells and zebrafish.

Peroxynitrite (ONOO) and viscosity are critical indicators of lysosome functionality, intimately linked to numerous diseases' pathophysiological processes. Hence, creating reliable analytical techniques to observe fluctuations in lysosomal ONOO and viscosity is highly important. This study presents the development of a novel naphthalimide-based fluorescent probe, Nap-Cy, specifically designed to target lysosomes and simultaneously detect both ONOO and viscosity.

AI-powered decision making for road safety optimization under probabilistic linguistic Sugeno-Weber aggregation information.

Traffic accidents, a global concern, pose threats to lives and carry substantial economic and societal burdens. This paper explores the innovative integration of artificial intelligence (AI) into the ambiance of Multi Criteria Decision Making (MCDM) to address the challenge. We investigate AI's potential to enhance road safety globally, utilizing data analysis, predictive modeling, and intelligent traffic management systems.

Salivary Nitrate Level and Lipid Profile in Patients with Hypertension: A Cross-Sectional Study in a Saudi Sub-Population.

: The use of salivary biomarkers offers a non-invasive approach to understanding the metabolic and inflammatory status of hypertensive patients. This study aimed to quantify the salivary nitric oxide (NO), total cholesterol, triglycerides, high-density lipoproteins (HDL), and low-density lipoproteins (LDL) levels in hypertensive individuals and healthy controls in a sub-population in Saudi Arabia. : This cross-sectional study comprised 40 hypertensive patients (test group, 40-50 years old) and 40 age-matched healthy controls who visited the dental hospital in the College of Dentistry, King Khalid University, for dental treatment.

NS2B-D55E and NS2B-E65D Variations Are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model.

Japanese encephalitis virus (JEV) NS2B-NS3 is a protein complex composed of NS3 proteases and an NS2B co-factor. The N-terminal protease domain (180 residues) of NS3 (NS3(pro)) interacts directly with a central 40-amino acid hydrophilic domain of NS2B (NS2B(H)) to form an active serine protease. In this study, the recombinant NS2B(H)-NS3(pro) proteases were prepared in and used to compare the enzymatic activity between genotype I (GI) and III (GIII) NS2B-NS3 proteases.

Green synthesized silicon dioxide nanoparticles (SiONPs) ameliorated the cadmium toxicity in melon by regulating antioxidant enzymes activity and stress-related genes expression.

Green synthesized nanoparticles (NPs) are an eco-friendly and cost-effective approach to reduce heavy metal stress in plants. Among heavy metals, cadmium (Cd) possesses higher toxicity to the crops and ultimately reduces their growth and yield. The current study aims to evaluate the effectiveness of green synthesized SiONPs to reduce toxic effects of Cd in melon (Cucumis melo) by regulating physiological parameters, enhancing antioxidant enzyme activity, and modulating stress-related gene expression.

Green entrepreneurial orientation and environmental performance a moderated mediation perspective of perceived environmental innovation and stakeholder pressure.

The current research examines how green entrepreneurial orientation affects environmental performance in Pakistan's manufacturing industries. It also examines the function of environmental innovation as a mediator in this relationship. In addition, stakeholder pressure is a moderating variable between green entrepreneurial orientation and environmental performance.

A multicenter study to evaluate the analytical precision by pathologists using the Aperio GT 450 DX.

Background: Digital pathology systems (DPS) are emerging as capable technologies for clinical practice. Studies have analyzed pathologists' diagnostic concordance by comparing reviews of whole slide images (WSIs) to glass slides (e.g.

Comparison of ilioinguial/iliohyphogastic nerves block with woundinfiltration on postoperative pain: A randomised controlled trial.

Objective: To compare postoperative pain scores at rest and on movement in patients undergoing open inguinal hernia repair between those receiving illioinguinal/illiohypogastric nerve block with ropivacaine or wound infiltration with ropivacaine.

Methods: The randomised clinical trial was conducted at the Department of Anaesthesiology, Aga Khan University Hospital a tertiary care centre from March to August 2019 and comprised patients of either gender scheduled for elective unilateral open inguinal hernia repair under general anaesthesia. They were randomised into illioinguinal/illiohypogastric nerve block group A, and wound infiltration group B.

Polarization dependent exciton-plasmon coupling in PEAPbI/Al and its application to perovskite solar cell.

This paper reports the strong coupling between Al nanostructure and two-dimensional (2D) layered perovskite PEAPbI (PEPI) films. The high exciton binding energy of 118 meV and long carrier lifetime of 216 ps are characterized from the 2D PEAPbI film, which indicates that the excitons in perovskite are robust and can couple to metal plasmons. The ordinary and extraordinary optical dispersions are revealed from the anisotropic 2D perovskite.

Structure-Guided Design of Affinity/Covalent-Bond Dual-Driven Inhibitors Targeting the AMP Site of FBPase.

Fructose-1,6-bisphosphatase (FBPase) has attracted substantial interest as a target associated with cancer and type II diabetes. FBPase inhibitors targeting the AMP allosteric site have been documented, but their limited selectivity has raised concerns about adverse effects. To address this issue, we designed the affinity/covalent-bond dual-driven inhibitors based on the pharmacophore knowledge of the AMP pocket and neighboring cysteine residue (C179) of FBPase using the cysteine-targeting reactivity warhead screen followed by a structural optimization strategy.

Enhancement of Glutamate Uptake as Novel Antiseizure Approach: Preclinical Proof of Concept.

Objective: Excitotoxicity is a common hallmark of epilepsy and other neurological diseases associated with elevated extracellular glutamate levels. Thus, here, we studied the protective effects of (R)-AS-1, a positive allosteric modulator (PAM) of glutamate uptake in epilepsy models.

Methods: (R)-AS-1 was evaluated in a range of acute and chronic seizure models, while its adverse effect profile was assessed in a panel of standard tests in rodents.

Role of leaf micro-structural modifications in modulation of growth and photosynthetic performance of aquatic halophyte Fimbristylis complanata (Retz.) under temporal salinity regimes.

Fimbristylis complanata is an aquatic halophytic sedge that thrives in salt-affected land, marshes, and water channels. Two ecotypes (HR-Rasool headworks ECe 19.45; SH- Sahianwala 47.

A Randomized Clinical Trial Comparing 2 Levothyroxine Regimens During Ramadan Fasting in Thyroidectomized Patients.

Context: For Muslim patients on levothyroxine (L-T4) therapy, the best approach for L-T4 intake during Ramadan fasting remains unclear.

Objective: We compared 2 practical approaches for L-T4 intake during Ramadan.

Methods: We randomly assigned 69 patients (21 males, 48 females, median age 44 years) with differentiated thyroid cancer (DTC) who underwent thyroidectomy in the past and are on stable LT4 doses to 2 arms.

Citrus psyllid management by collective involvement of plant resistance, natural enemies and entomopathogenic fungi.

Crops face constant threats from insect pests, which can lead to sudden disasters and global famine. One of the most dangerous pests is the Asian citrus psyllid (ACP), which poses a significant threat to citrus plantations worldwide. Effective and adaptive management strategies to combat ACP are always in demand.