Helical and kinase domain mutations of , and their association with hormone receptor expression in breast cancer.

Breast cancer is one of the major causes of female morbidity and mortality, accounting for ~25% of the total cancer cases in women. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic α subunit () mutations serve a major role in downstream signaling of receptor tyrosine kinases. The present study aimed to elucidate the frequency of exon 9 and 20 mutations of and their role in disease progression.

Effect of prophylactic vitamin D on anesthetic outcome in children with sickle cell disease.

Background: Few previous studies proved that complications related to sickle cell disease (SCD) were common with regional anesthesia compared with general anesthesia while others reported no differences. This study was carried out to evaluate the role of prophylactic vitamin D on anesthetic outcome among male children with SCD undergoing circumcision.

Materials And Methods: A comparative study was carried out on 58 children undergoing circumcision with the regional block under light general anesthesia.

Assessment of current undergraduate anesthesia course in a Saudi University.

Background: The assessment of the anesthesia course in our university comprises Objective Structured Clinical Examinations (OSCEs), in conjunction with portfolio and multiple-choice questions (MCQ). The objective of this study was to evaluate the outcome of different forms of anesthesia course assessment among 5(th) year medical students in our university, as well as study the influence of gender on student performance in anesthesia.

Methods: We examined the performance of 154, 5(th) year medical students through OSCE, portfolios, and MCQ.

Conservative treatment of processus vaginalis hernia in two peritoneal dialysis patients.

Dialysate leakage represents one of the major noninfectious complications of peritoneal dialysis (PD). In some instances, dialysate leakage may lead to discontinuation of the technique. Despite its importance, the incidence, risk factors, management, and outcome of dialysate leakage are poorly characterized in the literature.