Publications by authors named "Hamdin Cakar"
Article Synopsis
- Desmin is a protein that helps keep muscles strong and healthy, and problems with its gene (DES) can lead to serious heart and muscle diseases.
- Two new versions of this gene were found, one causing issues in muscle formation and another with unclear effects.
- The first version, DES-p.A120D, creates problems in muscle cells and could be linked to heart rhythm issues, while the second version, DES-p.H326R, doesn’t show clear differences from normal.
Background: In this study we analyzed putative biomarkers for myocardial remodeling in plasma from 55 endstage heart failure patients with the need for mechanical circulatory support (MCS). We compared our data to 40 healthy controls and examined if MCS by either ventricular assist devices or total artificial hearts has an impact on plasma concentrations of remodeling biomarkers.
Methods & Results: Plasma biomarkers were analysed pre and 30 days post implantation of a MCS device using commercially available enzyme linked immunosorbent assays (ELISA).