Publications by authors named "Hamard A"

Article Synopsis
  • The study investigates 16 primary cutaneous carcinomas with mutations in genes that activate the Wnt/β-catenin pathway, noting that these tumors lack matrical differentiation, which is typically associated with such mutations.
  • The tumors predominantly affected elderly patients, with a median age of 80, and were mainly located on the head, neck, and upper limbs, leading to metastatic cases in some patients.
  • Key findings include poor differentiation in tumor structure, distinct immunohistochemical profiles, and recurrent mutations in APC and CTNNB1, indicating that these tumors represent a unique group apart from other established skin tumor types.
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Poroma is a benign sweat gland tumour showing morphological features recapitulating the superficial portion of the eccrine sweat coil. A subset of poromas may transform into porocarcinoma, its malignant counterpart. Poroma and porocarcinoma are characterised by recurrent gene fusions involving YAP1, a transcriptional co-activator, which is controlled by the Hippo signalling pathway.

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Background: Ultra-low dose computed tomography (ULD-CT) was shown to be a good alternative to digital radiographs in various locations. This study aimed to assess the diagnostic sensitivity and specificity of ULD-CT versus digital radiographs in patients consulting for extremity traumas in emergency room.

Methods: Digital radiography and ULD-CT scan were performed in patients consulting at the emergency department (February-August 2018) for extremity traumas.

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Background: Percutaneous destructions of tumor lesions by ablation (microwave, radiofrequency or cryoablation) under computed tomography (CT) guidance allow high efficiency with minimally-invasive techniques, and acute needle placement and follow-up during procedure. This study investigated the impact of patient and technique parameters on the dose delivered during these procedures under CT guidance.

Methods: Data were extracted from a previous nationwide retrospective study.

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Background: Many computed tomography (CT) navigation systems have been developed to help radiologists improve the accuracy and safety of the procedure. We evaluated the accuracy of one CT computer-assisted guided procedure with different reduction dose protocols.

Methods: A total of 128 punctures were randomly made by two operators on two different anthropomorphic phantoms.

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Background: New reconstruction algorithms based on deep learning have been developed to correct the image texture changes related to the use of iterative reconstruction algorithms. The purpose of this study was to evaluate the impact of a new deep learning image reconstruction [Advanced intelligent Clear-IQ Engine (AiCE)] algorithm on image-quality and dose reduction compared to a hybrid iterative reconstruction (AIDR 3D) algorithm and a model-based iterative reconstruction (FIRST) algorithm.

Methods: Acquisitions were carried out using the ACR 464 phantom (and its body ring) at six dose levels (volume computed tomography dose index 15/10/7.

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Purpose: The purpose of this study was to compare the effect of two deep learning image reconstruction (DLR) algorithms in chest computed tomography (CT) with different clinical indications.

Material And Methods: Acquisitions on image quality and anthropomorphic phantoms were performed at six dose levels (CTDI: 10/7.5/5/2.

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Purpose: To compare the impact on CT image quality and dose reduction of two versions of a Deep Learning Image Reconstruction algorithm.

Material And Methods: Acquisitions on the CT ACR 464 phantom were performed at five dose levels (CTDI : 10/7.5/5/2.

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Purpose: To determine the suitable kVp pair for optimal image quality of the virtual monochromatic images (VMIs) and iodine quantification accuracy at low concentration, using a third generation dual-source CT (DSCT).

Materials And Methods: Multi-energy CT phantoms with and without body rings were scanned with a DSCT using four kVp pairs (tube "A"/"B" voltage): 100/Sn150, 90/Sn150, 80/Sn150 and 70/Sn150 kVp. The reference mAs was adjusted to obtain a CTDI close to 11 mGy.

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Purpose: To compare the organ-dose and effective-dose (E) delivered to the patient during percutaneous vertebroplasty (PVP) of one thoracic or lumbar vertebra performed under CT guidance or using a fixed C-arm.

Methods: Consecutive adult patients undergoing PVP of one vertebra under CT-guidance, with optimized protocol and training of physicians, or using a fixed C-arm were retrospectively included from January 2016 to June 2017. Organ-doses were computed on 16 organs using CT Expo 2.

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Background: Ultra low dose chest computed tomography (CT) acquisitions have been used for selected emergency room patients with acute dyspnea or minor thoracic trauma. The purpose of this study was to evaluate the diagnostic performance of ultra-low-dose (ULD) chest CT for detecting viral pneumonia patterns compared to standard (STD) dose chest CT.

Methods: All consecutive adult patients with two non-enhanced chest CT acquisitions, one STD and one ULD, for suspicion of viral pneumonia between March 5 and April 2 2020 were included.

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To assess the impact of the use of additional mattresses of different thicknesses on radiation dose and image noise based on the patient centering proposed by a 3D camera for CT. An anthropomorphic phantom was placed on mattresses of different thicknesses (from 3.5 to 13.

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Purpose: To assess the impact of dose reduction and the use of an advanced modeled iterative reconstruction algorithm (ADMIRE) on image quality in low-energy monochromatic images from a dual-source dual energy computed tomography CT (DSCT) platform.

Materials And Methods: Acquisitions on an image-quality phantom were performed using DSCT equipment with 100/Sn150 kVp for four dose levels (CTDI: 20/11/8/5mGy). Raw data were reconstructed for six energy levels (40/50/60/70/80/100 keV) using filtered back projection and two levels of ADMIRE (A3/A5).

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Placental mesenchymal dysplasia (PMD) and complete hydatidiform mole (CHM) with a coexisting fetus are 2 rare placental abnormalities characterized by lacunar placenta and presence of an embryo on ultrasound examination. We report the case of a 34-yr-old woman referred at 32.6 weeks of gestation because of a multicystic placenta.

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Objectives: To compare the spectral performance of dual-energy CT (DECT) platforms using task-based image quality assessment based on phantom data.

Materials And Methods: Two CT phantoms were scanned on four DECT platforms: fast kV-switching CT (KVSCT), split filter CT (SFCT), dual-source CT (DSCT), and dual-layer CT (DLCT). Acquisitions on each phantom were performed using classical parameters of abdomen-pelvic examination and a CTDI at 10 mGy.

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Purpose: To evaluate the feasibility of prostatic artery embolization in patients with low-risk prostate cancer (PC) under active surveillance (AS).

Methods: This monocentric prospective pilot study, running from June 2018 to June 2019, included 10 patients with low-risk PC under AS, median age 72 years (range, 62-77 years), with a unilateral focal lesion visible on magnetic resonance (MR) imaging, with Prostate Imaging Reporting and Data System v2 score ≥3/5 confirmed by multiparametric MR imaging-targeted biopsy and Gleason score 6. The patients underwent unilateral prostatic artery embolization with 300-500 μm Embospheres in the affected prostatic lobe.

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Objectives: To compare diagnosis performance and effective dose of ultra-low-dose CT (ULD CT) versus radiographs in suspected spinal or pelvic ring or hip fracture for minor trauma.

Methods: ULD CT, in addition to radiography, was prospectively performed in consecutive patients admitted to the emergency department for minor traumas, during working hours over 2 months. Presence of a recent fracture was assessed by two blind radiologists independently.

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Purpose: To assess the impact of iterative reconstructions on image quality and detectability of focal liver lesions in low-energy monochromatic images from a Fast kV-Switching Dual Energy CT (KVSCT) platform.

Methods: Acquisitions on an image-quality phantom were performed using a KVSCT for three dose levels (CTDI:12.72/10.

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Article Synopsis
  • Lung cancer is the deadliest cancer globally, and screening with low-dose computed tomography (LDCT) may improve outcomes for heavy smokers.
  • A systematic review and meta-analysis of seven randomized controlled trials involving over 84,000 participants showed that LDCT screening led to a 17% reduction in lung cancer-specific mortality.
  • The findings suggest that LDCT screening is effective in decreasing lung cancer deaths among populations with significant tobacco exposure.
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Purpose: To compare the evaluation of malignant focal liver lesions (FLLs) using a semi-automated RECIST tool with a standard and an ultra-low dose (ULD) computed tomography (CT) protocol.

Materials And Methods: Thirty-four patients with malignant FLLs underwent two abdominal-pelvic CT examinations one using a standard protocol and one using an ULD protocol. There were 23 men and 11 women with a mean age 64.

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Objectives: To validate the performance of an automatic tool to estimate a patient's peak skin dose (PSD) and a skin dose map from data collected by a radiation dose management system (RDMS) during interventional procedures.

Methods: In total, 288 eligible consecutive patients undergoing abdominopelvic embolisation or planned coronary angioplasty using radiochromic films were screened between June 2018 and March 2019. For 98 included patients, PSD was measured using radiochromic films (PSD) and computed by RDMS (PSD) using one flat and two anthropomorphic phantoms.

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Objectives: To assess the impact on image quality and dose reduction of a new deep learning image reconstruction (DLIR) algorithm compared with a hybrid iterative reconstruction (IR) algorithm.

Methods: Data acquisitions were performed at seven dose levels (CTDI : 15/10/7.5/5/2.

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Purpose: The purpose of this study was to assess the impact of tin filter (TF) on X-ray beam quality, image quality and radiation dose and its suitability for routine use for chest and lumbar-spine/pelvis-hip ultralow-dose (ULD) CT examination protocols.

Materials And Methods: The X-ray beam quality was determined by measuring the half-value layer (HVL) and calculating the mean weighted energy for 100, 120, 150kVp (using standard filtration) and for 100 and 150kVp using TF (Sn100kVp and Sn150kVp, respectively). Acquisitions were performed on a phantom at four dose levels for each previously definedkVp.

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Dactylitis refers to a global swelling of a finger or a toe giving it a clinical sausage-shape presentation. It is an extremely suggestive symptom as it guides the rheumatologist towards a shortlist of diagnoses. However, radiologists are less familiar with dactylitis.

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