Inverse dose protraction effects of high-LET radiation: evidence and significance.

Biological effects of ionizing radiation vary with radiation quality, which is often expressed as the amount of energy deposited per unit length, i.e., linear energy transfer (LET).

Inverse dose protraction effects of low-LET radiation: Evidence and significance.

Biological effects of ionizing radiation vary not merely with total dose but also with temporal dose distribution. Sparing dose protraction effects, in which dose protraction reduces effects of radiation have widely been accepted and generally assumed in radiation protection, particularly for stochastic effects (e.g.

Diffuse Alveolar Hemorrhage Due to Macrolide-Refractory Mycoplasma pneumoniae Diagnosed by FilmArray Analysis of Bronchoalveolar Lavage Fluid.

typically causes mild respiratory infections but can rarely lead to severe complications. We report a case of a 43-year-old immunocompetent male who presented with progressive dyspnea and respiratory failure with bilateral pulmonary infiltrates, refractory to outpatient treatment with azithromycin, ceftriaxone, and levofloxacin. Bronchoscopy revealed multiple white plaques in the trachea and diffuse alveolar hemorrhage.

Analysis of Departures from Linearity in the Dose Response for Japanese Atomic Bomb Survivor Solid Cancer Mortality and Cancer Incidence Data and Assessment of Low-Dose Extrapolation Factors.

Although leukemia in the Japanese atomic bomb survivor data has long exhibited upward curvature, until recently this appeared not to be the case for solid cancer. It has been suggested that the recently observed upward curvature in the dose response for the Japanese atomic bomb survivor solid cancer mortality data may be accounted for by flattening of the dose response in the moderate dose range (0.3-0.

Parental occupational exposure to anticancer drugs and radiation: Risk of fetal loss and physical abnormalities in The Japan Environment and Children's Study.

Background: Many studies have indicated an association between maternal occupational exposure to hazardous agents, such as anticancer drugs and ionizing radiation, and an increased risk of adverse pregnancy outcomes, including stillbirths or miscarriages and physical abnormalities in offspring. However, the effects of recent advancements in protective measures to reduce these risks have not been clarified. Aim To investigate the current impact of parental occupational exposure to anticancer drugs and ionizing radiation on stillbirths or miscarriages as well as physical abnormalities under the circumstances of the developed safety protocols.

Effect of carbonated water on cerebral blood flow in the frontal region: a study using near-infrared spectroscopy.

Introduction: Carbonated water (CarbW) affects the swallowing function associated with the action of the brainstem. In addition, CarbW ingestion promotes mean blood flow in the middle cerebral artery, which is associated with blood flow to the frontal and temporal lobes. In this milieu, studies regarding the effect of drinking CarbW on brain activity are of significance.

Testicular exposure to ionizing radiation and sperm epigenetic alterations as possible mechanisms of hereditary effects: perspectives from the viewpoint of radiation protection.

Purpose: Since the genotoxicity of ionizing radiation was demonstrated in the 1920s, its hereditary effects have remained a serious concern for human society. The International Commission on Radiological Protection has highlighted the need for appropriate protection against hereditary effects of radiation in humans. In this paper, we review the literature on the possible multigenerational and transgenerational effects following testicular exposure to radiation, focusing on sperm epigenetic alterations as possible mechanisms.

Novel Choline-Deficient and 0.1%-Methionine-Added High-Fat Diet Induces Burned-Out Metabolic-Dysfunction-Associated Steatohepatitis with Inflammation by Rapid Immune Cell Infiltration on Male Mice.

Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a progressive liver disorder that possesses metabolic dysfunction and shows steatohepatitis. Although the number of patients is globally increasing and many clinical studies have developed medicine for MASLD, most of the studies have failed due to low efficacy. One reason for this failure is the lack of appropriate animal disease models that reflect human MASLD to evaluate the potency of candidate drugs.

Hintonelmis spila sp. nov. (Elmidae: Elminae): a new species of riffle beetle from Amazonian region.

A new species, Hintonelmis spila sp. nov. from Brazil, Guyana, and Suriname, is described, illustrated, and diagnosed.

The F-0 exuvia of Protoneura paucinervis Selys, 1886 (Zygoptera: Protoneurinae): description and diagnosis.

The F-0 exuvia of Protoneura paucinervis Selys, 1886 is described, illustrated, and diagnosed by comparison with the hitherto known Protoneura Selys in Sagra, 1857 larvae. The larvae of P. paucinervis can be distinguished from its congeners by the following combination of characters: palpal lobe squared bearing three strong teeth, 5 palpal setae, and nodus of lateral gills at 0.

Ephydrolithus Girón & Short, 2019 (Coleoptera: Hydrophilidae): new species and updated distribution records from Northeast region of Brazil.

The Neotropical genus Ephydrolithus Girón & Short, 2019 was recently established based on five species. In 2022 five additional species were described, all of them from the Espinhaço Mountain Range, in the states of Minas Gerais and Bahia, Brazil. During an aquatic insect survey in three states in the Northeast region of Brazil, we collected two new species of Ephydrolithus in the states of Bahia, Ceará and Pernambuco, one of the new species collected in the two latter states, represent the first record of this genus outside the Espinhaço Mountain Range, expanding its distribution to other Brazilian states.

New Cernotina Ross 1938 (Trichoptera: Polycentropodidae) from Serra do Divisor, Acre, Brazil.

Two new species of the caddisfly genus Cernotina (Polycentropodidae) are described from the Parque Nacional da Serra do Divisor (PNSD), Acre, Brazil, Cernotina chicomendes sp. nov. and Cernotina divisor sp.

Insight into groundwater quality change before and after the 2016 Kumamoto earthquake.

The Kumamoto Earthquake is named after the Kumamoto Prefecture where the series of earthquakes occurred in the city located on the island of Kyushu, in southwest Japan. In this area, 100 % of the population depends on groundwater for drinking water; hence, groundwater is an extremely important lifeline for people. The effect of earthquakes on the water quality of groundwater has been suggested based on monitoring data measured by public agencies once or twice a year.

Candida Epiglottitis in a Patient Undergoing Chemotherapy for Small Cell Lung Cancer: A Case Report.

Epiglottitis is a critical infection that can result in upper airway obstruction. While bacterial infections are the most common cause of acute epiglottitis, Candida epiglottitis remains relatively rare. We report a case involving an 82-year-old male undergoing chemotherapy for small cell lung cancer.

The Clinical Significance of Interstitial Pneumonia with Autoimmune Features in Cryptogenic Organizing Pneumonia: A Prospective Multicenter Observational Study.

There are cases of idiopathic interstitial pneumonias (IIPs) that do not meet the diagnostic criteria for connective tissue disease but have clinical features suggestive of autoimmune process. Interstitial pneumonia with autoimmune features (IPAF) was recently proposed as a research concept for these patients. Although several prospective studies on IPAF have been conducted, its clinical significance in cryptogenic organizing pneumonia (COP) remains unclear.

Update of prognosis and characteristics of chronic obstructive pulmonary disease in a real-world setting: a 5-year follow-up analysis of a multi-institutional registry.

Background: We conducted a prospective observational study to elucidate the long-term prognosis and management of chronic obstructive pulmonary disease (COPD) in clinical practice in Japan in the mid-2010s.

Methods: This prospective cohort study included 29 facilities. Data from 427 patients clinically diagnosed with COPD, enrolled between September 2013 and April 2016, were analyzed.

Small Intestine Metastasis Leads to the Diagnosis of Thoracic SMARCA4-Deficient Undifferentiated Tumor: A Case Report.

SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a rare and aggressive malignancy characterized by the loss of SMARCA4 protein expression. It typically affects middle-aged male smokers and has a poor prognosis due to its rapid progression and metastatic potential. This case report presents a 73-year-old male diagnosed with a thoracic SMARCA4-UT.

Endometrial pattern predicts pregnancy outcome in single-blastocyst frozen-embryo transfer: An analysis of 1383 cycles.

Purpose: Several studies investigated endometrial patterns, with respect to pregnancy rates following the transfer of embryos but did not distinguish between single- and multiple-blastocyst procedures. We clarified how the endometrial pattern imaged to transfer a frozen embryo is associated with pregnancy outcomes in single-blastocyst frozen-embryo transfer (sbFET).

Methods: Patients ≤35 years who underwent sbFET on the hormone replacement protocol.