Improving Therapeutic Adherence and Reducing Therapeutic Inertia in the Management of People with Cardiometabolic Diseases: A Call-to-Action from the Middle East.

Hypertension, dyslipidemia, and type 2 diabetes are highly prevalent and poorly controlled cardiometabolic diseases in the Middle East. Therapeutic non-adherence and therapeutic inertia are major contributors to this suboptimal disease control. Regardless of the cardiometabolic disease, evidence-based solutions may be used to improve therapeutic non-adherence and overcome inertia, and thereby help to alleviate the heavy burden of cardiovascular disease in the Middle East.

Motor dysfunction in preschool children exposed to zika virus during pregnancy and normocephalic at birth: Developmental Coordination Disorder and Minimal Neurological Dysfunction.

The occurrence of motor dysfunctions was assessed at the age of 5 to 7 years in 61 normocephalic infants with prenatal Zika virus exposure. Traditional neurological examination, Touwen neurological examination, Movement Assessment Battery for Children-Second Edition (MABC-2) and the Developmental Coordination Disorder Questionnaire (DCDQ) were used to identify Developmental Coordination Disorder (DCD) and Minimal Neurological Dysfunction (MND). A high frequency of motor dysfunctions was found, 47 (81.

Boosting nutritional value: the role of iron fortification in meat and meat products.

Iron deficiency is a widespread nutritional problem affecting millions of people globally, leading to various health issues including anemia. Iron fortification of meat and meat products has emerged as an effective strategy to combat this issue. This review explores the process and benefits of iron fortification, focusing on the types of iron compounds suitable for fortification, such as ferrous sulfate and ferric pyrophosphate, their bioavailability, and their impact on the sensory and nutritional qualities of meat products.

From Gut to Brain: The Impact of Short-Chain Fatty Acids on Brain Cancer.

The primary source of short-chain fatty acids (SCFAs), now recognized as critical mediators of host health, particularly in the context of neurobiology and cancer development, is the gut microbiota's fermentation of dietary fibers. Recent research highlights the complex influence of SCFAs, such as acetate, propionate, and butyrate, on brain cancer progression. These SCFAs impact immune modulation and the tumor microenvironment, particularly in brain tumors like glioma.

Tofersen for SOD1 amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Objective: Tofersen, an antisense oligonucleotide, has recently received FDA and EMA approval for treating amyotrophic lateral sclerosis (ALS) in adults with SOD1 gene mutations. This systematic review and meta-analysis synthesized evidence on tofersen's safety and efficacy in patients with SOD1-related ALS.

Methods: A comprehensive search of three databases was conducted from inception through October 2024.

Transnational Healthcare Practices Among Migrants: A Concept Analysis.

Aims: To present a conceptual definition of transnational healthcare in the context of migrant older adults.

Design: This article follows the Walker and Avant concept analysis framework to conduct an in-depth analysis of transnational healthcare.

Methods: Databases were searched for scholarly articles using keywords associated with transnational healthcare.

Exosomal signaling in gynecologic cancer development: The role of cancer-associated fibroblasts.

Gynecologic cancer, a prevalent and debilitating disease affecting women worldwide, is characterized by the uncontrolled proliferation of cells in the reproductive organs. The complex etiology of gynecologic cancer encompasses multiple subtypes, including cervical, ovarian, uterine, vaginal, and vulvar cancers. Despite optimal treatment strategies, which typically involve cytoreductive surgery and platinum-based chemotherapy, gynecologic cancer frequently exhibits recalcitrant relapse and poor prognosis.

Caffeine and Arrhythmias: A Critical Analysis of Cardiovascular Responses and Arrhythmia Susceptibility.

Caffeine is a frequently consumed stimulant in different foods and beverages: coffee, tea, chocolate, sodas, and energy drinks. While its effects on the cardiovascular system have been extensively studied, there remains controversy surrounding its potential risks, particularly in patients with heart disease. This review provides a complete overview of caffeine's pharmacological properties, sources, and cardiovascular effects, particularly emphasizing its arrhythmogenic potential.

Exploring the Experiences and Perspectives of new Graduate Nurses on the Push-Pull Factors of Nursing Workforce Crisis Post COVID-19.

Background: The aim of this study is to explore the practice experiences of new graduate nurses (NGNs) in publicly funded acute healthcare settings in the Greater Toronto Area, their perspectives on the determinants of their desire to stay or leave the nursing profession, and to identify action-oriented strategies to promote retention of NGNs.

Design: Qualitative, descriptive.

Methods: Fifteen NGNs participated in focus group sessions, where a semi-structured interview guide was created to generate discussion on NGNs' lived and professional experiences.

Environmental Factors, Occupational Hazards, and Seasonal Changes: Unveiling the Triggers of Atrial Fibrillation.

Introduction: Atrial Fibrillation (AF) is the most common cardiac arrhythmia in the world, with a lifetime risk of 26% for men and 23% for women. AF is a prevalent cardiac arrhythmia that is more common with increasing age. Globally, around 33.

Design of a novel multi-epitope vaccine candidate against using advanced immunoinformatics approaches: An in silico study.

is the perilous pandemics that occurred in Asia and Europe. The bacterium has shown drug resistance that can cause the future pandemic and destroy the drug treatment against plague. As known, effective therapeutics such as designing potent vaccine that can aid world to protect against plague.

Acceptability, Feasibility, and Uptake of COVID-19 Antigen Rapid Diagnostic Self-Testing at the Community Level in Tanzania.

The rapid diagnosis of coronavirus disease 2019 (COVID-19) is critical for comprehensive public health response strategies, and self-testing with antigen rapid diagnostic tests (Ag-RDTs) presents opportunities to test in hard-to-reach communities. Therefore, we evaluated the acceptability, feasibility, and uptake of Ag-RDT self-testing at the community level in Tanzania. From June to October 2022, symptomatic individuals or those with recent contact with a known or suspected COVID-19 patient were offered assisted testing and self-testing within mining communities and at transport hubs.

Homestay Hosting Dynamics and Refugee Well-Being: Scoping Review.

Background: Homestay accommodations aim to support a smoother transition for refugees; yet, the intricate nature of relationships between refugees and their hosting families can make this process complex, which, in turn, can affect their health and well-being. It is crucial to grasp the experiences of both refugees and their host families in order to foster effective settlement, integration, and well-being.

Objective: The purpose of this scoping review is to explore the dynamics of homestay or hosting with a focus on understanding the experiences of both refugees and their hosting families to identify gaps in the literature and propose directions for future research.

Adaptive congestion control in IoT networks: Leveraging one-way delay for enhanced performance.

With the exploding number of IoT devices generating vast data volumes, there is a growing risk of significant performance degradation without efficient congestion management. To tackle this challenge, efficient regulation and supervision are essential for managing congestion in IoT networks. This research work introduces a One-Way-Delay (OWD)-based congestion control (CC) method that estimates data transmission delays of the communication path and adjusts network traffic accordingly.

Metformin plus lifestyle interventions versus lifestyle interventions alone for the delay or prevention of type 2 diabetes in individuals with prediabetes: a meta-analysis of randomized controlled trials.

Objectives: We conducted this meta-analysis of randomized controlled trials (RCTs) to compare the efficacy of adding metformin to lifestyle interventions versus lifestyle interventions alone in individuals with prediabetes.

Materials And Methods: We searched four databases from inception until March 20, 2024. Our primary outcomes included the incidence of type 2 diabetes, hemoglobin A1c (HbA1c), and fasting plasma glucose (FPG).

The recommended patient syndrome: Charting new frontiers.

Introduction: Very important person (VIP) syndrome, or recommended patient syndrome (RPS), is a phenomenon in healthcare where well-intentioned efforts to enhance care inadvertently result in harm. Celebrities, physicians, and political leaders often receive preferential treatment, leading to potentially unnecessary interventions. This review delves into its causes, manifestations, consequences, real-life instances, prevention, and management, considering the shifting paradigm of recent advances in the medical field.

Activation of algicidal bacteria and nitrogen-phosphorus removal bacteria during controlling cyanobacteria bloom in Taihu lake by artemisinin algaecide.

Cyanobacterial harmful algal blooms (CyanoHABs) in Taihu Lake pose a persistent environmental challenge. This study investigated the inhibitory effects of artemisinin algaecide (AMA) on cyanobacteria in Taihu Lake and assessed its impact on nutrients, as well as the structures of particle-attached (PA) and free-living (FL) bacterial communities and potential ecological mechanisms. The results indicated that A-3 (0.

Identification of Genes Associated with Familial Focal Segmental Glomerulosclerosis Through Transcriptomics and In Silico Analysis, Including , , and .

Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and often leads to progressive kidney failure. Its varying clinical presentation suggests potential genetic diversity, requiring further molecular investigation. This study aims to elucidate some of the genetic and molecular mechanisms underlying FSGS.

Correction: Detection of the levels of immune cytokines (IL4, IL5, TNF-α) in school-age and preschoolers with an infection.

[This corrects the article DOI: 10.1007/s12639-024-01715-w.].

HER2-low non-metastatic breast cancer in Qatar-a nationwide retrospective cohort study to evaluate the response to neoadjuvant chemotherapy: a real-world analysis.

Globally, breast cancer is the most prevalent cancer and one of the leading causes of cancer-related death among women. HER2-low breast cancer represents a recently identified molecular category within breast cancer characterized by tumors displaying only slight overexpression of HER2 or lacking gene amplification. To illustrate, HER2-low tumors typically have an IHC (immune histochemistry) score of 1+ or 2+ with negative amplification.