Is Neuregulin-4 a predictive marker of microvascular complications in type 2 diabetes mellitus?

Background And Aims: Neuregulin-4 (Nrg-4) is a new adipokine released from brown adipose tissue. It plays pivotal role in regulating systemic energy balance, glucose and lipid metabolism and in reducing chronic inflammation. We aimed to investigate the relation between diabetic microvascular complications (DMC) and serum (Nrg-4) levels in patients with type 2 diabetes mellitus.

MEAN PLATELET VOLUME: AN OVERLOOKED HERALD OF MALIGNANT THYROID NODULES.

Physicians and surgeons pay much attention to evaluating thyroid nodules due to the malignant potential of these growths. Inflammation has a crucial role in the development of cancer. Increase in the mean platelet volume (MPV) has been described in various inflammatory conditions.

Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus.

Background: Neuregulin-4 is a cytokine with many functions and is primarily produced by fat tissue.

Aim Of The Study: The aim of the study was to observe the relationship between serum neuregulin-4 levels and diabetes regulation in type 2 diabetes mellitus (T2DM), and to compare neuregulin-4 levels of diabetic subjects with those in healthy controls.

Methods: Patients with T2DM were included to the study.

Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy?

Objective: In this study, we aimed to analyze the relationship between serum uric acid (UA) and microalbuminuria as a marker of renal injury in type 2 diabetes mellitus.

Methods: A total of 100 patients with type 2 diabetes mellitus were enrolled in the study. Participants were divided into two groups according to the urinary microalbumin/creatinine ratio: diabetic nephropathy and non-nephropathy group.

Association between novel inflammatory markers derived from hemogram indices and metabolic parameters in type 2 diabetic men.

Aim: Hemogram indices were proposed as novel inflammatory markers in chronic conditions and inflammation has substantial role in the pathogenesis of type 2 diabetes mellitus (T2DM). We aimed to observe hemogram parameters of type 2 diabetic male subjects with various age groups in well and poorly controlled subsets.

Methods: Data of type 2 diabetic men enrolled to the study were recorded from patient files of the institution.

Type 2 diabetes mellitus is more commonly well controlled in younger men compared to older men.

Methods: The male patients with T2DM that admitted to the outpatient internal medicine clinics of our institution between November 2018 and April 2019 were included to the study. According to the age, study population divided into two groups; either younger than 60 years (group I) and 60 years or older (group II). Study parameters were compared between study groups.

Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus.

Background: Type 2 diabetes mellitus is associated with chronic low grade inflammation. One of the novel inflammatory markers is hemogram derived neutrophil to lymphocyte ratio (NLR).

Objective: We aimed to compare NLR levels of diabetic subjects and healthy controls and to observe possible correlation between NLR and HbA1c.

Neutrophil to Lymphocyte Ratio is Useful in Differentiation of Malign and Benign Thyroid Nodules.

Objective: Significant amount of thyroid nodules are malignant. Inflammation plays crucial role in the pathogenesis of many disorders, including cancer. Neutrophil to lymphocyte ratio (NLR), has been suggested as an index of inflammatory response and association between increased NLR and cancer has also been reported.

Diabetic regulation of subjects with type 2 diabetes mellitus is associated with serum vitamin D levels.

Objective: Vitamin D deficiency is not only associated with bone metabolism but also with diabetes mellitus. We aimed to study the possible association between serum vitamin D concentration and HbA1c level in patients with type 2 diabetes mellitus (T2DM) in this retrospective report.

Methods: Patients with T2DM were enrolled to the study either in regulated or non-regulated T2DM groups, according to HbA1c levels.

Diabetes control could through platelet-to-lymphocyte ratio in hemograms.

Objective: Association between type 2 diabetes mellitus and inflammation is well-established. We aimed to study platelet-to-lymphocyte ratio (PLR), a novel inflammatory index derived from hemogram, in diabetic patients in comparison to those in healthy volunteers.

Methods: Medical data of type 2 diabetics that showed up in general outpatient medical clinics of our institution between February 2017 and August 2017 were recorded and analyzed.

Mean Platelet Volume to Lymphocyte Ratio as a Novel Marker for Diabetic Nephropathy.

Objective: To compare mean platelet volume to lymphocyte ratio (MPVLR) of diabetic nephropathy subjects to those diabetics without diabetic nephropathy.

Study Design: Observational, cross-sectional study.

Place And Duration Of Study: Tertiary referral hospital, in Bolu, Turkey, from July to December 2017.

A Case of Secondary Hypertension due to Giant Hydatid Cyst.

Hydatid cyst is a parasitic infection which causes enormous morbidity and mortality worldwide. The pathogenic organism responsible for hydatid cyst is Echinococcus granulosus. Despite the fact that the characteristic cysts of the disease usually occur in liver and lungs, they may also occur in aberrant localisations.

Haemogram Parameters in Vitamin D Deficiency.

Objective: To study haemogram derived inflammatory indices, mean platelet volume (MPV), red cell distribution width (RDW), and neutrophil to lymphocyte ratio (NLR) in vitamin D deficient patients and to compare to those subjects with normal vitamin D levels.

Study Design: Descriptive study.

Place And Duration Of Study: Abant Izzet Baysal University Hospital, Bolu, Turkey, from March to May 2017.

A Rare Non-Hemolytic Case of Idiopathic Cold Agglutinin Disease.

Background: Cold agglutinin disease is a very rare condition associated with agglutination of erythrocytes in cold environment usually due to IgM type antibodies. Other than hemolytic anemias, it may interfere with routine hemogram tests due to miscalculation of red blood cell count (RBC) and other hemogram parameters calculated with involvement of RBC. Awareness of the condition is important to overcome laboratory errors.

Analysis of the Factors Related to the Blood Pressure Control in Hypertension.

Objective: To determine the factors associated with blood pressure control and comparing anthropometric and clinical parameters of subjects with well-controlled hypertension to those with poorly controlled blood pressure.

Study Design: Observational cross-sectional study.

Place And Duration Of Study: Abant Izzet Baysal University Hospital, Bolu, Turkey, from January to June 2016.

Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto's thyroiditis.

Objective: Hashimoto's thyroiditis (HT) is an autoimmune inflammatory disorder. The purpose of this study was to determine the neutrophil-to-lymphocyte ratio (NLR), a novel marker of inflammation, in patients with HT and to compare these values with those from healthy subjects.

Method: A total of 154 participants were included in the study, 90 HT patients and 64 healthy volunteers.

Could Red Cell Distribution Width be a Marker of Thyroid Cancer?

Objective: To study red cell distribution width (RDW) values, a novel inflammatory marker in routine hemogram, of patients with benign or malignant thyroid nodules and to compare with healthy population.

Study Design: Descriptive study.

Place And Duration Of Study: Abant Izzet Baysal University Hospital, Bolu, Turkey, from November 2015 and February 2017.

Red cell distribution width and mean platelet volume in patients with irritable bowel syndrome.

Introduction: Possible pathophysiological mechanisms of irritable bowel syndrome (IBS) are interactions between microbial flora of the gut and the mucosal/systemic immune system, post-infectious status and inflammation. Mean platelet volume (MPV) and red cell distribution width (RDW) have been reported as inflammatory markers in patients with inflammatory bowel disease, but they have not been studied in functional gastrointestinal disorders.

Aim: To investigate whether there was an association between haemogram parameters (RDW and MPV) and IBS.

Serum levels of omentin in end-stage renal disease patients.

Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in hemodialysis patients. Therefore, evaluation and prevention of cardiovascular diseases in end-stage renal disease (ESRD) patients are very important. The plasma level of omentin was found to be associated with different conditions such as insulin resistance.

A Fascioliasis Case: a not Rare Cause of Hypereosinophilia in Developing Countries, Present in Developed too.

Fascioliasis is a worlwide parasitic zoonosis, endemic in south-east mediterranean area, but uncommon in other areas. Clinical signs are usually non-specific. A 32 year old male patient was admitted to our hospital with complaints of abdominal pain, diarrhea, fatigue, nausea, lost of appetite, itching, cough, night sweats and weight loss.

Takayasu arteritis initially mimicking infective endocarditis.

Takayasu's arteritis (TA) is a chronic inflammatory disease that affects large vessels, predominantly the aorta and its main branches, leading to vessel wall thickening, fibrosis and stenosis. Cardiac and vascular symptoms are also commonly present at disease onset. In TA with thoracic or abdominal involvement, although murmur can be present at physical examination, the pulse difference may be absent.

An interesting cause of pulmonary emboli: acute carbon monoxide poisoning.

Carbon monoxide poisoning, a public health problem of considerable significance, is a relatively frequent event today, resulting in thousands of hospitalizations annually. A 70-year-old lady was seen in the emergency department with a provisional diagnosis of carbon monoxide poisoning. The previous night, she slept in a tightly closed room heated with coal ember.