Interferon-α Inhibits NET Formation in Neutrophils Derived from Patients with Myeloproliferative Neoplasms in a Neutrophil Sub-Population-Specific Manner.

Neutrophils and neutrophil extracellular traps (NETs) contribute to thrombosis and hyperinflammation in myeloproliferative neoplasms (MPN). High-density neutrophils (HDNs) and low-density neutrophils (LDNs) have recently been characterized as distinct neutrophil sub-populations with distinct morphological and functional properties. We aim to study the kinetics of NET formation and inhibition with interferon-α (IFNα) in neutrophils derived from patients with MPN as compared to matched healthy controls.

What is the most effective antibiotic monotherapy for severe Pseudomonas aeruginosa infection? A systematic review and meta-analysis of randomized controlled trials.

Objectives: To compile the evidence of sub-groups of patients with Pseudomonas aeruginosa (P. aeruginosa) infection from randomized control trials (RCTs) evaluating different definite antipseudomonal monotherapies for severe P.aeruginosa infection.

Attitude moralization in the context of collective action: How participation in collective action may foster moralization over time.

Although much is known about why people engage in collective action participation (e.g., politicized identity, group-based anger), little is known about the psychological consequences of such participation.

Introducing the Bidimensional Model of Hope and its conceptual and methodological utilities.

What is hope, and how can we measure it? These questions have occupied the minds of hope scholars across disciplines. This article outlines a comprehensive approach to understanding hope: the Bidimensional Model of Hope. Building on the standard definition of hope, the bidimensional model explores hope as the intersection between wishes (desires, aspirations) and expectations (assessment of possibility).

Single-cell DNA methylome and 3D genome atlas of the human subcutaneous adipose tissue.

Human subcutaneous adipose tissue (SAT) contains a diverse array of cell-types; however, the epigenomic landscape among the SAT cell-types has remained elusive. Our integrative analysis of single-cell resolution DNA methylation and chromatin conformation profiles (snm3C-seq), coupled with matching RNA expression (snRNA-seq), systematically cataloged the epigenomic, 3D topology, and transcriptomic dynamics across the SAT cell-types. We discovered that the SAT CG methylation (mCG) landscape is characterized by pronounced hyper-methylation in myeloid cells and hypo-methylation in adipocytes and adipose stem and progenitor cells (ASPCs), driving nearly half of the 705,063 detected differentially methylated regions (DMRs).

Attraction to politically extreme users on social media.

Political segregation is a pressing issue, particularly on social media platforms. Recent research suggests that one driver of segregation is -people's preference for others in their political group who have more extreme (rather than more moderate) political views. However, acrophily has been found in lab experiments, where people choose to interact with others based on little information.

The affective gap: a call for a comprehensive examination of the discrete emotions underlying affective polarization.

Bakker and Lelkes (2024) point at a critical gap in research on affective polarisation: the limited understanding of its affective components, mainly due to the reliance on a unidimensional operationalisation of affect in affective polarisation. They advocate for a broader approach to study affect, integrating explicit and implicit measures, and call on emotion specialists to address this gap. Acknowledging the complexity of affect in the ideological divide, we argue that the lack of a thorough examination of the distinct role of discrete emotions constitutes the primary "affective gap".

CML in the very elderly: the impact of comorbidities and TKI selection in a real-life multicenter study.

Tyrosine kinase inhibitors (TKIs) have greatly improved chronic myeloid leukemia (CML) treatments, with survival rates close to the general population. Yet, for the very elderly, robust data remains limited. This study focused on assessing comorbidities, treatment approaches, responses, and survival for elderly CML patients.

Genome wide association study and genomic risk prediction of age related macular degeneration in Israel.

The risk of developing age-related macular degeneration (AMD) is influenced by genetic background. In 2016, the International AMD Genomics Consortium (IAMDGC) identified 52 risk variants in 34 loci, and a polygenic risk score (PRS) from these variants was associated with AMD. The Israeli population has a unique genetic composition: Ashkenazi Jewish (AJ), Jewish non-Ashkenazi, and Arab sub-populations.

Zoom out: An intervention on the virtual learning environment improves minority students' grades in two field experiments in Israel.

Closing the achievement gap for minority students in higher education requires addressing the lack of belonging these students experience. This paper introduces a psychological intervention that strategically targets key elements within the learning environment to foster the success of minority students. The intervention sought to enhance Palestinian minority student's sense of belonging by increasing the presence of their native language.

Between victory and peace: Unravelling the paradox of hope in intractable conflicts.

Previous research on group-based hope has predominantly focused on positive intergroup outcomes, such as peace and harmony. In this paper, we demonstrate that hope experienced towards group-centric political outcomes, such as a victory in a conflict and defeating the enemy, can be detrimental to peace. In Study 1, conducted among Israeli Jews, hope for victory over the Palestinians was uniquely associated with more support for extreme war policies, whereas hope for peace generally showed the opposite associations.

Defend, Deny, Distance, and Dismantle: A New Measure of Advantaged Identity Management.

The experience of privilege can trigger psychological conflict among advantaged group members. Nonetheless, little work has explored strategies that advantaged group members use to manage their identities as privileged actors. Building on Knowles et al.

Disadvantaged group members are prouder of their group when using the language of the dominant group compared to their native language.

In ethnically and linguistically diverse societies, disadvantaged groups often face pressures to acquire and speak the advantaged group's language to achieve social inclusion and economic mobility. This work investigates how using the advantaged group's language affects disadvantaged group members' in-group pride and collective self-esteem, relative to using their native language. Across six experimental studies involving Palestinian citizens of Israel (total = 1,348), we test two competing hypotheses: Disadvantaged group members may experience greater in-group pride when using a) their native language, due to its emotional significance (the ), or b) the language of the advantaged group, due to activation of habituated compensatory responses to dominance relations (the ).

Intergroup psychological interventions: The motivational challenge.

Social scientists have increasingly applied insights from descriptive research to develop psychological interventions aimed at improving intergroup relations. These interventions have achieved marked success-reducing prejudicial attitudes, fostering support for conciliatory social policies, and promoting peacebuilding behaviors. At the same time, intergroup conflict continues to rage in part because individuals often lack motivation to engage with these promising interventions.

SLIViT: a general AI framework for clinical-feature diagnosis from limited 3D biomedical-imaging data.

We present SLIViT, a deep-learning framework that accurately measures disease-related risk factors in volumetric biomedical imaging, such as magnetic resonance imaging (MRI) scans, optical coherence tomography (OCT) scans, and ultrasound videos. To evaluate SLIViT, we applied it to five different datasets of these three different data modalities tackling seven learning tasks (including both classification and regression) and found that it consistently and significantly outperforms domain-specific state-of-the-art models, typically improving performance (ROC AUC or correlation) by 0.1-0.

How our ideological out-group shapes our emotional response to our shared socio-political reality.

What shapes our emotional responses to socio-political events? Following the social identity approach, we suggest that individuals adjust their emotional responses to socio-political stimuli based on their ideological out-group's responses, in a manner that preserves the comparative and normative fit of ideological in-group-out-group categories. In Study 1 and Study 2 (pre-registered), Jewish-Israeli leftists and rightists were exposed to their ideological out-group's alleged emotional response to a stimulus associated with Israeli-Palestinian relations, which was either stereotypical (leftists expressing low anger and rightists expressing high anger) or non-stereotypical (leftists expressing high anger and rightists expressing low anger). Across studies, participants reported more positive affect towards their ideological out-group when its response to the stimulus was non-stereotypical versus stereotypical, yet their own response to the stimulus became more "extreme" (towards the low end of the anger scale for leftists, and towards the high end of the anger scale for rightists), shifting farther away from their ideological out-group norm.

Should I Stay or Should I Go? Motives and Barriers for Sustained Collective Action Toward Social Change.

Israel's year-long protest calling for Prime Minister Netanyahu's resignation created an opportunity to examine unique factors influencing (SCA; i.e., repeated participation in social movement action for the same cause).