Efficient injury risk predictions for a diverse population using parametric human modeling and inducing points in Gaussian processes.

Objective: The objective of this study is to use parametric human modeling and machine learning methods to identify representative occupants that can account for injury variations among a more diverse population with a limited simulation budget.

Method: A maximal projection method was used to sample 100 occupants, considering the variations in stature, weight, and sitting height. An automated mesh morphing method was used to morph the THUMS v4.

Predicting Regression of Barrett's Esophagus-Can All the King's Men Put It Together Again?

The primary pre-neoplastic lesion of the lower esophagus in the vicinity of the gastroesophageal junction (GEJ) is any Barrett's esophageal lesions (BE), and esophageal neoplasia has increased in the US population with predispositions (Caucasian males, truncal obesity, age, and GERD). The responses to BE are endoscopic and screening cytologic programs with endoscopic ablation of various forms. The former have not been proven to be cost-effective and there are mixed results for eradication.

Standardized Assessment of Gravity Settling Human Body Models for Virtual Testing.

The increased use of computational human models in evaluation of safety systems demands greater attention to selected methods in coupling the model to its seated environment. This study assessed the THUMS v4.0.

Status May Differentiate Two Distinct Pathways of Gastric Adenocarcinoma Carcinogenesis.

Background: We evaluated the phenotype of sporadic gastric cancer based on HP status and binding of a tumor risk marker monoclonal, Adnab-9.

Methods: We compared a familial GC kindred with an extremely aggressive phenotype to HP-positive (HP+) and -negative (HP-) sporadic gastric adenocarcinoma (GC) patients in the same community to determine if similar phenotypes exist. This might facilitate gene discovery to understand the pathogenesis of aggressive GC phenotypes, particularly with publications implicating immune-related gene-based signatures, and the development of techniques to gauge the stance of the innate immune system (InImS), such as the FERAD ratio (blood ferritin:fecal Adnab-9 binding OD-background binding).

The Effects of Recline Angle and Restraint Geometry on Lap Belt-Pelvis Interaction for Above-Normal BMI Motor Vehicle Occupants.

The interaction of the three-point seat belt with the occupant, particularly the lap belt with the pelvis, is affected by a multitude of intrinsic and extrinsic factors, including the torso recline angle, lap belt angle, and occupant body mass index (BMI). While field data analyses have shown the strong safety benefit for seat belt use regardless of occupant size or crash direction, the term "submarining" historically has been used to describe a scenario in which the lap belt loads the abdominal soft tissue and organs, superior and posterior to the pelvic bone. While contemporary restraint systems work to effectively address the risk of submarining in occupants properly seated and properly belted, scenarios in which the lap belt may not properly engage the load-bearing pelvis remain.

Effect of axial compression on stiffness and deformation of human lumbar spine in flexion-extension.

Objective: The goal of this study was to evaluate the effect of axial compression, employed with a follower-load mechanism, on the response of the lumbar spine in flexion and extension bending. Additional goals include measurement of both the kinetic (stiffness) and kinematic (deformation distribution) responses, evaluating how the responses vary across specimens, and to develop response corridors that can be used to evaluate human body models (HBMs) and anthropomorphic test devices (ATDs).

Methods: Seven mid-sized male adult lumbar spines (T12-S1) from postmortem human surrogates were tested in subinjurious flexion and extension bending with 0, 900, and 1800 N of superimposed axial compression.

Human Lumbar Spine Injury Risk in Dynamic Combined Compression and Flexion Loading.

Anticipating changes to vehicle interiors with future automated driving systems, the automobile industry recently has focused attention on crash response in novel postures with increased seatback recline. Prior research found that this posture may result in greater risk of lumbar spine injury in the event of a frontal crash. This study developed a lumbar spine injury risk function (IRF) that estimated injury risk as a function of simultaneously applied compression force and flexion moment.

A naturalistic study of passenger seating position, posture, and restraint use in second-row seats.

Objective: The objective of the current study was to increase scientific understanding of rear-seat passenger seating position, postures, CRS use, and belt use through a naturalistic study. A secondary objective was to compare data from vehicles used in ride-hailing with data from other vehicles.

Method: Video cameras were installed in the passenger cabins of the vehicles of 75 drivers near the center of the windshield.

Failure tolerance of the human lumbar spine in dynamic combined compression and flexion loading.

Vehicle safety systems have substantially decreased motor vehicle crash-related injuries and fatalities, but injuries to the lumbar spine still have been reported. Experimental and computational analyses of upright and, particularly, reclined occupants in frontal crashes have shown that the lumbar spine can be subjected to simultaneous and out-of-phase combined axial compression and flexion loading. Lumbar spine failure tolerance in combined compression-flexion has not been widely explored in the literature.

U.S. vehicle occupancy trends relevant to future automated vehicles and mobility services.

Objective: Identifying current occupant travel patterns can inform decision making regarding the design, regulation, and occupant protection systems helpful for automated vehicle systems and mobility services.

Methods: Two travel data sets were analyzed to quantify travel patterns: the 2017 National Household Travel Survey (NHTS), which provides data on household trips logged for a 24-h period, and the 2011-2015 National Automotive Sampling System-General Estimates System (NASS-GES), which contains data sampled from police-reported crashes. Analysis identified trends with driver age and gender, occupant age and gender, time of day, day of week, trip purpose, trip duration, vehicle type, as well as occupant role as solo driver, driver of others, single passenger, or multiple passengers.

Effect of Temperature and Freezing on Human Adipose Tissue Material Properties Characterized by High-Rate Indentation: Puncture Testing.

The characterization of human subcutaneous adipose tissue (SAT) under high-rate loading is valuable for development of biofidelic finite element human body models (FE-HBMs) to predict seat belt-pelvis interaction and injury risk in vehicle crash simulations. While material characterization of SAT has been performed at 25 °C or 37 °C, the effect of temperature on mechanical properties of SAT under high-rate and large-deformation loading has not been investigated. Similarly, while freezing is the most common preservation technique for cadaveric specimens, the effect of freeze-thaw on the mechanical properties of SAT is also absent from the literature.

Multidirectional mechanical properties and constitutive modeling of human adipose tissue under dynamic loading.

The mechanical behavior of subcutaneous adipose tissue (SAT) affects the interaction between vehicle occupants and restraint systems in motor vehicle crashes (MVCs). To enhance future restraints, injury countermeasures, and other vehicle safety systems, computational simulations are often used to augment experiments because of their relative efficiency for parametric analysis. How well finite element human body models (FE-HBMs), which are often used in such simulations, predict human response has been limited by the absence of material models for human SAT that are applicable to the MVC environment.

Video from user-generated content as a source of pre-crash scenario naturalistic driving data.

Objective: The objective of this study was to investigate the use of public video from internet user-generated content as a means of collecting naturalistic driving data.

Methods: A convenience sample of 38 videos comprised of 203 events was extracted from publicly available channels on the YouTube™ platform. Each event was manually reviewed and pseudo-coded according to a subset of current CRSS variables.

Comparison of porcine and human adipose tissue loading responses under dynamic compression and shear: A pilot study.

Understanding the mechanical properties of human adipose tissue, and its influence on seat belt-pelvis interaction is beneficial for computational human body models that are developed for injury prediction in the vehicle crashworthiness simulations. While various studies have characterized adipose tissue, most of the studies used porcine adipose tissue as a surrogate, and none of the studies were performed at loading rates relevant for motor vehicle collisions. In this work, the mechanical response of human and porcine adipose tissue was studied.

Prevalence of non-nominal seat positions and postures among front-seat passengers.

Objective: Recent studies have suggested that a relationship exists between crash injury risk and occupant posture, particularly in postures different from those used with anthropomorphic test devices (ATDs) in crash testing. The objective of this study was to increase scientific understanding of typical front-seat passenger postures through a naturalistic study.

Method: Video cameras were installed in the passenger cabins of the vehicles of 75 drivers.

Age Differences in Occupant Motion during Simulated In-Vehicle Swerving Maneuvers.

Background: With active safety and automated vehicle features becoming more available, unanticipated pre-crash vehicle maneuvers, such as evasive swerving, may become more common, and they may influence the resulting effectiveness of occupant restraints, and consequently may affect injury risks associated with crashes. Therefore, the objective of this study was to quantify the influence of age on key occupant kinematic, kinetic, and muscular responses during evasive swerving in on-road testing.

Methods: Seat belt-restrained children (10-12 years old), teens (13-17 years old), and adults (21-33 years old) experienced two evasive swerving maneuvers in a recent model sedan on a test track.

Comparison of three-point belt fit between humans and Hybrid-III anthropometric test devices in a driver mockup.

The Hybrid-III anthropometric test devices (ATDs) are widely used by the automotive industry to evaluate restraint system performance in standardized vehicle crash tests. The relationship between the belt fit measured for people in driving posture and the belt fit obtained with ATDs has not been reported in the literature. The present study compares lap and shoulder belt fit data from ATDs and to a statistical estimate for drivers using age, stature, and BMI.

Characterization of the motion of booster-seated children during simulated in-vehicle precrash maneuvers.

Precrash occupant motion may affect head and trunk position and restraint performance in a subsequent crash, particularly for young children. Others have studied seat belt-restrained adult drivers and adult and adolescent passengers in precrash maneuvers. For younger children, optimal restraint includes a belt-positioning booster seat, which in precrash maneuvers may contribute in unique ways to the overall body motion.

Effect of automated versus manual emergency braking on rear seat adult and pediatric occupant precrash motion.

Emergency braking can potentially generate precrash occupant motion that may influence the effectiveness of restraints in the subsequent crash, particularly for rear-seated occupants who may be less aware of the impending crash. With the advent of automated emergency braking (AEB), the mechanism by which braking is achieved is changing, potentially altering precrash occupant motion. Further, due to anatomical and biomechanical differences across ages, kinematic differences between AEB and manual emergency braking (MEB) may vary between child and adult occupants.

Driver head locations: Considerations for head restraint design.

Objective: U.S. FMVSS 202a requires that a vehicle head restraint lie within a specified distance (55 mm) from the physical headform on the head restraint measurement device (HRMD).

Passenger head kinematics in abrupt braking and lane change events.

Objective: A test track study was conducted to quantify patterns of adult front seat passenger head motion during abrupt vehicle maneuvers.

Method: Eighty-seven men and women with a wide range of body sizes and ages participated in data collection on a closed test track in a passenger sedan under manual control by a test driver. Because a primary goal of the study was to gather "unaware" data, the participants were instructed that the study was concerned with vehicle dynamics and they were required to read from a questionnaire taped to the top of their thighs as the drive began.