FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.

Autoimmune thyroid disease is the most common autoimmune disease and is highly heritable. Here, by using a genome-wide association study of 30,234 cases and 725,172 controls from Iceland and the UK Biobank, we find 99 sequence variants at 93 loci, of which 84 variants are previously unreported. A low-frequency (1.

Antibiotic susceptibility of Helicobacter pylori in Iceland.

Background: Increasing resistance of Helicobacter pylori (H. pylori) to antibiotics calls for constant re-evaluation of multidrug regimens that have been used to eradicate the infection. The aim of this study was to evaluate the current antibiotic susceptibility of H.

[Mediastinal parathyroid cyst - a case report].

The most common causes of mediastinal masses are thymomas, lymphomas and neuromas. Mediastinal cysts, such as bronchogenic cysts, which are usually benign, are less common. We report the case of a 59-year-old woman with a history of progressive dysphagia.

Irritable bowel syndrome: physicians' awareness and patients' experience.

Aim: To study if and how physicians use the irritable bowel syndrome (IBS) diagnostic criteria and to assess treatment strategies in IBS patients.

Methods: A questionnaire was sent to 191 physicians regarding IBS criteria, diagnostic methods and treatment. Furthermore, 94 patients who were diagnosed with IBS underwent telephone interview.

Natural history of irritable bowel syndrome in women and dysmenorrhea: a 10-year follow-up study.

Background. Studies have shown that women are more likely to have irritable bowel syndrome (IBS) and more women seek healthcare because of IBS than men. Aim.

Natural history of functional gastrointestinal disorders: comparison of two longitudinal population-based studies.

Background: Functional gastrointestinal disorders are common but information on their natural history is limited.

Aims: To document the natural history of functional gastrointestinal disorders in a population based study and to compare with the Olmsted County study.

Method: A questionnaire was mailed to the same age- and gender-stratified random sample of the Icelandic population aged 18-75 in 1996 and 2006.

Natural history of heartburn: a 10-year population-based study.

Aim: To study the natural history and prevalence of heartburn at a 10-year interval, and to study the effect of heartburn on various symptoms and activities.

Methods: A population-based postal study was carried out. Questionnaires were mailed to the same age- and gender-stratified random sample of the Icelandic population (aged 18-75 years) in 1996 and again in 2006.

Natural history of functional dyspepsia: a 10-year population-based study.

Background: Functional dyspepsia (FD) is a common disorder, but information on its natural history is limited.

Aim: To study the natural history of FD as assessed by 2 criteria over a 10-year period.

Method: A population-based study conducted by mailing a questionnaire to the same age- and gender-stratified random sample of the Icelandic population aged 18-75 in 1996 and again in 2006.

[Prevalence of Helicobacter pylori and Cag-A strains in patients with duodenal ulcer in Iceland.].

Objective: The prevalence of Helicobacter pylori infection and related gastric diseases is rapidly changing in western societies. H. pylori has been associated with gastritis, gastric and duodenal ulcer and gastric cancer.

[Epidemiological study of functional bowel disorders in Iceland].

Objective: The aim of the present study was to evaluate the prevalence of functional bowel disorders (FBD) in a population-based sample and to assess FBD-related health care seeking and medication in Iceland.

Material And Methods: A self-report questionnaire was sent to a random sample of 2000 inhabitants, 18-75 years of age. The questionnaire addressed 46 gastrointestinal symptoms and 42 other health related, sociodemographic and psychosomatic symptom items.

Antimitochondrial antibodies and reactivity to N. aromaticivorans proteins in Icelandic patients with primary biliary cirrhosis and their relatives.

Objectives: Primary biliary cirrhosis (PBC) is a chronic, progressive cholestatic disease of unknown etiology characterized by serum antimitochondrial antibodies (AMA) directed against a functionally related family of mitochondrial enzymes. We recently suggested that N. aromaticivorans might be the trigger of autoimmunity in PBC.

Subclinical intestinal inflammation: an inherited abnormality in Crohn's disease relatives?

Background & Aims: One approach to unraveling the genetics of complex inherited disease, such as Crohn's disease, is to search for subclinical disease markers among unaffected family members. We assessed the possible presence, prevalence, and inheritance pattern of subclinical intestinal inflammation in apparently healthy relatives of patients with Crohn's disease.

Methods: A total of 49 patients with Crohn's disease, 16 spouses, and 151 (58%) of 260 available first-degree relatives underwent a test for intestinal inflammation (fecal calprotectin concentration).