[Activity of street drugs].

In the seized samples, the concentrations of diamorphine (heroin) varied from zero to more than seventy percent and the concentrations of cocaine from zero to more than ninety percent. Such variations in concentrations of active constituents constitute a major risk for those who use and abuse street drugs.

Del(14)(q22) in diffuse B-cell lymphocytic lymphoma.

Some recurrent chromosomal abnormalities have recently been found to be associated with distinctive histologic subtypes of non-Hodgkin's lymphoma (NHL). In a study of 62 patients with NHL whose karyotypes was determined at diagnosis, 3 patients were found to have a deletion of the long arm of chromosomes 14 at band 22 (del[14][q22]). All had a diffuse lymphoma with generalized lymphadenopathy and bone marrow involvement.

[Experimental colonic cancers].

An experimental model of colonic cancer can be obtained in rodents by administration of 1-2 Dimethylhydrazine. It produces constant, reproducible lesions, ranging from simple anomalies of secretion to invasive cancers, which are identical to those observed in man. It should be noted that the rats and mice used in these experiments do not present spontaneous colonic tumours.

[Benign mammographic stellar images. Apropos of 15 cases].

15 stellar types breast lesions were reviewed and classified according their etiology (fibrosing adenosis, dysplasia, dystrophy, radial scar of Aschoff, fat necrosis). Radio-anatomical confrontation allowed to understand the images given by the varying appearances of the connective skeleton surrounded by adipose lobules. The authors study the diagnosis of the stellar breast lesions and recall the determinant role of connective tissue in the genesis of mammographic stellar images.

[Diagnosis of tumor recurrence within the breast after tumor removal for cancer, followed or not by radiotherapy. Apropos of 23 cases].

The diagnostic value of mammography was evaluated retrospectively in 23 recurrent carcinomas in patients previously treated by partial mastectomy with or without adjuvant radiotherapy. Mammography established accurate diagnosis in 11 of the 23 patients. Mammography should always be performed in addition to clinical and cytological examinations and results must be evaluated jointly.

[Fibrosing adenosis (eleven cases reported) (author's transl)].

The authors studied eleven cases of Fibrosing Adenosis of the breast. If the clinical findings and radiologic examination evoke this diagnosis only a histological proof is sure. The difficulties in histological diagnosis, the problems of the histogenesis of fibrosing adenosis are emphasized.

Preneoplastic changes in epithelium and mesenchyme in colon of rats treated with 1,2-dimethylhydrazine.

Twenty-eight rats were given weekly injections of 1,2-dimethylhydrazine (DMH) for periods of 1-10 weeks. The preneoplastic changes occurring in the descending colon were monitored by transmission electron microscopy. Marked uniformity was observed in the time period of lesion development in the colon induced by the carcinogen especially at the epithelialstromal junction in preneoplastic lesions.

[Unusual tumours of the digestive tract (author's transl)].

The authors summarize the difficulties in diagnosis some tumour-like lesions or digestive tumours. They rely upon thirty years experience in digestive pathology and upon a survey of relevant literature. They recall the difficulties arising from the inflammatory tumour-like lesions (infiltrating sclerosis or granulomas, colitis cystica profunda, inflammatory polyps).