Anti-oxidative and anti-inflammatory effects of lipoic acid in rat liver.

Introduction: Lipopolysaccharide (LPS) is a key inflammatory component of Gram-negative bacteria, which after entering the systemic circulation contributes to the development of septic hepatic failure.

Aim: The aim of this study was to evaluate the effects of alpha lipoic acid (LA) on oxidative stress parameters and inflammation in endotoxemic rat liver.

Material/methods: Male Wistar rats were divided into 4 groups, each group consisting of 8 animals.

[Effect of extremely low frequency magnetic field on glutathione in rat muscles].

Background: Free radicals (FR) are atoms, molecules or their fragments. Their excess leads to the development of oxidizing stress, the cause of many neoplastic, neurodegenerative and inflammatory diseases, and aging of the organism. Industrial pollution, tobacco smoke, ionizing radiation, ultrasound and magnetic field are the major FR exogenous sources.

[Influence of lipoic acid on the level of TNF-alpha in spleen homogenates].

Unlabelled: Lipoic acid (LA) is a natural antioxidant and possess beneficial effects on oxidative stress parameters in various tissues. The aim of the study was to estimate of influence of LA on free -SH groups and TNF-alpha levels in spleen homogenates in rats during oxidative stress induced by LPS.

Material And Methods: Experiments were performed on Wistar rats devided into 4 groups: group I (control) received 0,9% NaCl; group II --received LA (100 mg/kg); group III received LPS (10 mg/kg); group IV--received LPS (10 mg/kg) and 30 min later received LA at the dose 100 mg/kg.

Effects of lipoic acid on spleen oxidative stress after LPS administration.

Background: Bacterial endotoxin (lipopolysaccharide - LPS) is a strong modulator of the immune system that plays a crucial role in the pathogenesis of endotoxic shock. The aim of the study was to investigate the effects of lipoic acid (LA) on oxidative stress markers in spleen homogenates obtained from LPS-induced endotoxic shock rats.

Methods: The animals were treated with saline or lipoic acid (LA) (60 or 100 mg/kg b.

[The influence of lipoic acid on total protein concentration in the liver and spleen tissue in rats during lipopolysaccharide-induced oxidative stress].

The Aim Of The Study: To evaluate the influence of lipoic acid on total protein concentration in the liver and spleen in rats during endotoxemia.

Material And Methods: Experiments were performed on Wistar rats divided into following groups: Group I (control) received saline; Group II (LA) received lipoic acid (60 mg/kg b.w.

Lipoic acid - biological activity and therapeutic potential.

α-Lipoic acid (LA; 5-(1,2-dithiolan-3-yl)pentanoic acid) was originally isolated from bovine liver by Reed et al. in 1951. LA was once considered a vitamin.

[Role of lipoic acid in health and disease].

Oxidative stress disturbs organism's homeostasis and leads to excessive reactive oxygen species (ROS) production. Researchers are still focused on antioxidants that help to reduce oxidative stress level and are helpful in treatment of diseases were ROS overproduction is observed. Among those antioxidants is lipoic acid (LA).