Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis.

Study Question: Is there molecular evidence for a link between endometriosis and endometriosis-associated ovarian cancers (EAOC)?

Study Answer: We identified aberrant gene expression signatures associated with malignant transformation in a small subgroup of women with ovarian endometriosis.

What Is Known Already: Epidemiological studies have shown an increased risk of EAOC in women with ovarian endometriosis. However, the cellular and molecular changes leading to EAOC are largely unexplored.