Anemia in pregnancy: a systematic review and meta-analysis of prevalence, determinants, and health impacts in Egypt.

Background: The WHO considers anemia in pregnancy a severe public health issue when prevalence surpasses 40%. In response, we conducted a systematic review and meta-analysis to examine anemia among pregnant women in Egypt, focusing on its prevalence, determinants, and associated complications.

Methods: We conducted a systematic literature search for studies published between January 1, 2010, and August 18, 2024, to identify studies from Egypt reporting on anemia in pregnant women, including its prevalence, associated determinants, and complications.

Assessment of dynamics of pathogenic environmental T4 and T9 genotypes isolated from three recreational lakes in Klang Valley, Malaysia over the HaCaT cell monolayer.

Free-living amoebae of the genus are causative agents of keratitis and amoebic encephalitis. They are widely found in various ecological environments. Therefore, the present study brings results that can help to better understand the genotypes of the environmental isolates and their pathogenicity.

Wastewater treatment using Moringa oleifera (Lam.) and Eichhornia crassipes (Mart.) as neutral-carbon options within the framework of COP 27 recommendations.

Contamination of water by heavy toxic metal ions such as (e.g., Cr, Mn, Ni, Cu, Zn, As Pb, Cd, and Ag) can lead to serious environmental and human health problems because of their acute and chronic toxicity to the biological system.

Mannan oligosaccharides as a prebiotic for laying hens: effects on fertility, hatchability, productive performance, and immunity.

This experiment examined how adding mannan-oligosaccharides (MOS) to the diet affected fertility, hatching rates, egg production, carcass characteristics, cost-effectiveness, and immune function in laying hens. One hundred and twenty Mandarah chickens (30 hens and 3 roosters per group) were randomly chosen between 34 and 50 wk old and divided into four groups. The first group was the control group, which was given just the basal diet.

L. Promotes wound healing by upregulating expression of TGF-β, IL-1 β, VEGF and MMP-2.

L. has been traditionally used for treating snakebites and is known to possess antifebrile and hemostatic properties. These properties are closely related to wound healing.

New porous amine-functionalized biochar-based desiccated coconut waste as efficient CO adsorbents.

Climate change caused by the greenhouse gases CO remains a topic of global concern. To mitigate the excessive levels of anthrophonic CO in the atmosphere, CO capture methods have been developed and among these, adsorption is an especially promising method. This paper presents a series of amine functionalized biochar obtained from desiccated coconut waste (amine-biochar@DCW) for use as CO adsorbent.

Screening and Experimental Validation of Novel MexAB-OprM Efflux Pump Inhibitors of .

The emergence of multidrug-resistant possesses a significant public health concern. Constitutively expressed MexAB-OprM efflux pumps in significantly contribute to its resistance to a variety of antibiotics. The development of efflux pump inhibitors (EPIs) has emerged as an attractive strategy in reversing antibiotic resistance.

Prion protein conversion at two distinct cellular sites precedes fibrillisation.

The self-templating nature of prions plays a central role in prion pathogenesis and is associated with infectivity and transmissibility. Since propagation of proteopathic seeds has now been acknowledged a principal pathogenic process in many types of dementia, more insight into the molecular mechanism of prion replication is vital to delineate specific and common disease pathways. By employing highly discriminatory anti-PrP antibodies and conversion-tolerant PrP chimera, we here report that de novo PrP conversion and formation of fibril-like PrP aggregates are distinct in mechanistic and kinetic terms.

The Possible Ameliorating Role of Fisetin on Hepatic Changes Induced by Fluoxetine in Adult Male Albino Rats: Histological, Immunohistochemical, and Biochemical Study.

Background: Fluoxetine (FLX) is one of the selective serotonin reuptake inhibitors, it is widely used to treat neuropsychiatric disorders including depression, but high doses can cause several adverse effects. Fisetin (FIS), a bioactive flavonoid presents in vegetables and fruits, has antioxidant, anti-inflammatory, and anticancer effects.

Aim: To evaluate the possible ameliorating effect of FIS on the hepatic alterations induced by FLX in adult male albino rats.

Omicron subvariants illustrate reduced respiratory tissue penetration, cell damage and inflammatory responses in human airway epithelia.

Introduction: To explore whether the reported lower pathogenicity in infected individuals of variant of concern (VoC) Omicron and its current subvariants compared to VoC Delta may be related to fundamental differences in the initial virus-tissue interaction, we assessed their ability to penetrate, replicate and cause damage in a human 3D respiratory model.

Methods: For this, we used TEER measurements, real-time PCR, LDH, cytokine and complex confocal imaging analyses.

Results And Discussion: We observed that Delta readily penetrated deep into the respiratory epithelium and this was associated with major tissue destruction, high LDH activity, high viral loads and pronounced innate immune activation as observed by intrinsic C3 activation and IL-6 release at infection sites.

Molecular insights into the HLA-B35 molecules' classification associated with HIV control.

Human leukocyte antigen (HLA) class I molecules have been shown to influence the immune response to HIV infection and acquired immunodeficiency syndrome progression. Polymorphisms within the HLA-B35 molecules divide the family into two groups, namely, Px and PY. The Px group is associated with deleterious effects and accelerated disease progression in HIV patients, whereas the PY group is not.

Manic episode following psilocybin use in a man with bipolar II disorder: a case report.

There has been an increase in research on the topic of psychedelic substances and their effects as treatment options in neuropsychiatric conditions. Psilocybin is a psychedelic drug that has recently garnered increased interest as an effective treatment modality for treatment-resistant depression, depression associated with terminal conditions, certain substance use disorders, and obsessive-compulsive disorder. However, sparse data exist as to the effects that psilocybin might have on patients at risk for mania, in large part secondary to the exclusion of this patient population from studies due to the concern for inducing mania or worsening illness course.

Molecular characterisation and potential pathogenicity analysis of Acanthamoeba isolated from recreational lakes in Peninsular Malaysia.

The present study aims to identify the Acanthamoeba genotypes and their pathogenic potential in three recreational lakes in Malaysia. Thirty water samples were collected by purposive sampling between June and July 2022. Physical parameters of water quality were measured in situ while chemical and microbiological analyses were performed in the laboratory.

Influence of dietary mannan-oligosaccharides supplementation on hematological characteristics, blood biochemical parameters, immune response and histological state of laying hens.

This study aimed to determine the influence of dietary mannan-oligosaccharides (MOS) on the immune system, hematological traits, blood biochemical parameters, and histological state of laying hens. At 34 wk of age, The Mandarah chicken strain's 120 laying hens and 12 cocks were divided into 4 groups, each with 30 hens and 3 cocks. The first group performed as a control group, which nourished on a basal diet.

Machine learning molecular dynamics simulation of CO-driven formation of Cu clusters on the Cu(111) surface.

The behavior of adsorbate-induced surface transformation can be clearly understood given the mechanical aspects of such phenomenon are well described at the atomic level. In this study, we provide the atomic-level description on the formation of Cu clusters on the Cu(111) surface by performing set of molecular dynamics simulations driven by machine-learning force-field. The simulations at 450 K-550 K show clusters are formed within a hundred of ns when the Cu surface is exposed with CO.

Immune response, hematological traits, biochemical blood parameters, and histological status of laying hens influenced by dietary chitosan-oligosaccharides.

This experiment aimed to examine the effect of chitosan-oligosaccharides (COS) supplementation in laying hens' diets affected their immune response, hematological characteristics, blood biochemical parameters, and histological status. At the age of 34 wk, 200 laying hens and 20 cocks of the Mandarah chicken strain were allotted into four groups, each consisting of 50 hens and five cocks. The first group acted as a control group, fed on a basal diet.

Association between angiotensin converting enzyme gene polymorphism (rs4343) and susceptibility to gestational hypertension and preeclampsia in pregnant women.

Hypertension is the most frequent medical complication of pregnancy, and the most severe clinical presentation of hypertensive disorders of pregnancy (HDP) is preeclampsia (PE). PE is a condition significantly associated with maternal and perinatal morbidity and mortality. The etiology of PE remains unknown.

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts.

Background: Many therapeutic modalities are available for treating genital warts; however, the effectiveness of both diphenylcyclopropenone and podophyllin is still controversial.

Aim: To evaluate the effectiveness and safety of diphenylcyclopropenone and podophyllin in treating genital warts.

Methods: This study included 57 patients, divided randomly into two groups.

The relationality of parts for narrative identity constitution in the corporate profile translations of China's multinational corporations.

The corporate profile translations of multinational corporations (MNCs) in emerging economies such as China possess rich information for narrative analysis. Nevertheless, how the parts of a corporate profile translation form a whole narrative remains undertheorized. This study, therefore, examines the relationality of parts in the corporate profile translations of China's MNCs by integrating William Labov's narrative structure with Margaret Somers' narrative identity theory.

Elucidation of Cu-Zn Surface Alloying on Cu(997) by Machine-Learning Molecular Dynamics.

The Cu-Zn surface alloy has been extensively involved in the investigation of the true active site of Cu/ZnO/AlO, the industrial catalyst for methanol synthesis which remains under controversy. The challenge lies in capturing the interplay between the surface and reaction under operating conditions, which can be overcome given that the explicit dynamics of the system is known. To provide a better understanding of the dynamic of Cu-Zn surface at the atomic level, the structure and the formation process of the Cu-Zn surface alloy on Cu(997) were investigated by machine-learning molecular dynamics (MD).

The Determinants of Non-compliance on Rabies Vaccination in North-West Peninsular Malaysia.

Introduction: Rabies post-exposure vaccination (Rabies PEV) remains the most fundamental prevention of human Rabies if administered in a timely and appropriate manner. The study was aimed to determine the proportion and determinants of non-compliance on Rabies PEV among dog bite patients in Perlis, Malaysia from July 2015 to June 2020.

Methods: A retrospective cohort study was conducted using Perlis Rabid Potential Animal Bite Registry data.

In Vitro Cytopathogenic Activities of T3 and T4 Genotypes on HeLa Cell Monolayer.

Amoebic keratitis and encephalitis are mainly caused by free-living amoebae of the genus , which consists of both pathogenic and nonpathogenic species. The global distribution, amphizoic properties and the severity of the disease caused by species have inspired the scientific community to put more effort into the isolation of , besides exploring the direct and indirect parameters that could signify a pathogenic potential. Therefore, this study was performed to characterize the pathogenic potential of isolated from contact lens paraphernalia and water sources in Malaysia.

Cilgavimab/Tixagevimab as alternative therapeutic approach for BA.2 infections.

Objectives: The identification of the SARS-CoV-2 Omicron variants BA.1 and BA.2 immediately raised concerns about the efficacy of currently used monoclonal antibody therapies.