Microbes, allergic sensitization, and the natural history of asthma.

Purpose Of Review: Understanding factors that lead to asthma development in early life is essential to developing strategies aimed at primary or secondary prevention.

Recent Findings: This article will review current evidence addressing the development of early life allergic sensitization in relation to microbes and the gut and airway microbiome. Wheezing illnesses, particularly viral, remain a significant risk factor for asthma inception; however, bacterial pathogens have recently emerged as an additional important contributor to asthma risk, either alone or as cofactors with viral infections.

Dust Mite-Induced Perennial Allergic Rhinitis in Pediatric Patients and Sublingual Immunotherapy.

Allergic rhinitis (AR) is a common illness in children and can impair their quality of life. Furthermore, many children remain symptomatic despite maximizing systemic antihistamine and topical therapies. It is at this clinical juncture that immunotherapy may be considered.

Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development.

Background: Biomarkers, preferably noninvasive, that predict asthma inception in children are lacking.

Objective: Little is known about biomarkers of type 2 inflammation in early life in relation to asthma inception. We evaluated aeroallergen sensitization, peripheral blood eosinophils, and serum periostin as potential biomarkers of asthma in children.