Publications by authors named "Haley R Barlow"
The molecular links between tissue-level morphogenesis and the differentiation of cell lineages in the pancreas remain elusive despite a decade of studies. We previously showed that in pancreas both processes depend on proper lumenogenesis. The Rab GTPase Rab11 is essential for epithelial lumen formation in vitro, however few studies have addressed its functions in vivo and none have tested its requirement in pancreas.
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- Endothelial cells (ECs) are crucial for heart valve formation, but researchers have struggled to identify specific markers to study their functions in valve development effectively.
- A study identified the gene Cyp26b1, found in the endocardium of developing heart valves, as essential for normal valve development, with its absence leading to thickened aortic valve leaflets and ventricular septal defects in mouse models.
- The research indicates that Cyp26b1 plays a role in regulating retinoic acid-dependent pathways during heart valve morphogenesis, highlighting the need to better understand the expression of cardiac EC genes to address normal and defective valve development.
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- Cell competition is a process where stronger (fitter) cells eliminate weaker (less-fit) neighboring cells, helping maintain normal development and tissue health.
- Researchers developed a new in vitro model using interspecies pluripotent stem cells (PSCs) to explore how competition occurs between cells from different species and found this competition is more evident in primed than naive PSCs.
- By analyzing gene activity, they discovered that genes linked to the NF-κB signaling pathway were more active in the less-fit 'loser' human cells, and modifying certain genes helped improve the survival and integration of human cells in early mouse embryos, potentially aiding in creating human tissues in animals.
Proper organ development depends on coordinated communication between multiple cell types. Retinoic acid (RA) is an autocrine and paracrine signaling molecule essential for the development of most organs, including the lung. Despite extensive work detailing effects of RA deficiency in early lung morphogenesis, little is known about how RA regulates late gestational lung maturation.
View Article and Find Full Text PDFThe Hippo pathway directs cell differentiation during organogenesis, in part by restricting proliferation. How Hippo signaling maintains a proliferation-differentiation balance in developing tissues via distinct molecular targets is only beginning to be understood. Our study makes the unexpected finding that Hippo suppresses nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) signaling in pancreatic progenitors to permit cell differentiation and epithelial morphogenesis.
View Article and Find Full Text PDFBlood vessels are required for the survival of any organism larger than the oxygen diffusion limit. Blood vessel formation is a tightly regulated event and vessel growth or changes in permeability are linked to a number of diseases. Elucidating the cell biology of endothelial cells (ECs), which are the building blocks of blood vessels, is thus critical to our understanding of vascular biology and to the development of vascular-targeted disease treatments.
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