Enantioselective Synthesis of the Guaipyridine Alkaloid (+)- and (-)-Cananodine.

Synthesis of both enantiomers of guaipyridine alkaloid cananodine was achieved. The stereocenter at C8 was set through an Evans alkylation, and the seven-membered carbocycle was constructed using an intramolecular Mizoroki-Heck reaction. Hydrogenation of an exomethylene set the C5 stereocenter.

Exploring Nanogeochemical Environments: New Insights from Single Particle ICP-TOFMS and AF4-ICPMS.

Nanogeochemistry is an emerging focus area recognizing the role of nanoparticles in Earth systems. Engineered nanotechnology has cultivated advanced analytical techniques that are also applicable to nanogeochemistry. Single particle inductively coupled plasma ICP-time-of-flight-mass spectrometry (ICP-TOF-MS) promises a significant step forward, as time-of-flight mass analyzers enable simultaneous quantification of the entire atomic mass spectrum (∼7-250 / ).