Publications by authors named "Haley Lopez"
Article Synopsis
- The study investigates genetic variants linked to early-onset ischemic stroke (EOS) in individuals aged 18-59, contrasting with previous research focused on late-onset stroke (LOS).
- Researchers conducted a meta-analysis involving 16,730 EOS cases and 599,237 controls to identify significant genetic associations and compared results between EOS and LOS.
- Findings include two genetic variants associated with blood subgroups that show a stronger connection to EOS than LOS, indicating that genetic factors promoting blood clotting are particularly influential in early-onset cases.
Article Synopsis
- The study aimed to analyze the connection between marijuana use and the risk of ischemic stroke, while also controlling for tobacco smoking and other confounding factors.* -
- Conducted as a case-control study with 751 stroke cases and 813 controls, researchers used interviews and statistical analysis to examine how marijuana use related to stroke risk across various demographics.* -
- Results indicated no significant link between marijuana use and early-onset ischemic stroke risk, although there was a slight trend suggesting increased risk for those using marijuana weekly; overall, the findings highlighted limited statistical power for very heavy users.*
Background And Purpose: The role of copy number variation (CNV) variation in stroke susceptibility and outcome has yet to be explored. The Copy Number Variation and Stroke (CaNVAS) Risk and Outcome study addresses this knowledge gap.
Methods: Over 24,500 well-phenotyped IS cases, including IS subtypes, and over 43,500 controls have been identified, all with readily available genotyping on GWAS and exome arrays, with case measures of stroke outcome.
Background And Purpose: The genetic contribution to ischemic stroke may include rare- or low-frequency variants of high-penetrance and large-effect sizes. Analyses focusing on early-onset disease, an extreme-phenotype, and on the exome, the protein-coding portion of genes, may increase the likelihood of identifying such rare functional variants. To evaluate this hypothesis, we implemented a 2-stage discovery and replication design, and then addressed whether the identified variants also associated with older-onset disease.
View Article and Find Full Text PDFBackground And Purpose: Approximately 8% of Blacks have sickle cell trait (SCT), and there are conflicting reports from recent cohort studies on the association of SCT with ischemic stroke (IS). Most prior studies focused on older populations, with few data available in young adults.
Methods: A population-based case-control study of early-onset IS was conducted in the Baltimore-Washington region between 1992 and 2007.