Defining cis-regulatory elements and transcription factors that control human cortical interneuron development.

Although human cortical interneurons (cINs) are a minority population in the cerebral cortex, disruption of interneuron development is a frequent contributor to neurodevelopmental disorders. Here, we utilized a model for deriving cINs from human embryonic stem cells to profile chromatin state changes and generate an atlas of -regulatory elements (CREs) controlling human cIN development. We used these data to define candidate transcription factors (TFs) that may bind these CREs to regulate interneuron progenitor specification.

Neuronal cadherins: The keys that unlock layer-specific astrocyte identity?

An astrocyte's intricate morphology is essential for proper brain function, but the intrinsic and extrinsic cues that set astrocyte morphology are largely unknown. In this issue, Tan et al. (https://doi.

The diversity of ABC transporter genes across the Phylum Nematoda.

It is estimated that one billion people globally are infected by parasitic nematodes, with children, pregnant women, and the elderly particularly susceptible to morbidity from infection. Control methods are limited to de-worming, which is hampered by rapid re-infection and the inevitable development of anthelmintic resistance. One family of proteins that has been implicated in nematode anthelmintic resistance are the ATP binding cassette (ABC) transporters.