High-resolution visualization of cosmetic active compounds in hair using nanoscale secondary ion mass spectrometry.

A wide range of small molecules are used in our daily hair products to improve the appearance of hair and to protect it from damage from the environment. In order to better design formulations of these products, an understanding of the partitioning and distributions of these small molecules in hair is critical. In this study, we used preferential extraction methods to measure the partitioning of active compounds commonly found in hair cosmetic products on the hair surface and inside hair, and investigated the use of stable isotope labelling, cryo-sample preparation and nanoscale secondary ion mass spectrometry (NanoSIMS) for high-resolution visualization of distributions of these compounds.

Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters.

Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field chemicals, construction, paper, adhesives, and textiles. They have particular value in pharmaceutical applications due to characteristics including high glass transition temperatures, high chemical and photochemical stability, solubility, limited crystallinity, hydrogen bonding capability, and low toxicity. With regard to toxicity, cellulose ethers have essentially no ability to permeate through gastrointestinal enterocytes and many are already in formulations approved by the U.

Multidrug, Anti-HIV Amorphous Solid Dispersions: Nature and Mechanisms of Impacts of Drugs on Each Other's Solution Concentrations.

Drug therapy has been instrumental in prolonging the lives of patients infected by human immunodeficiency virus (HIV). In order to combat development of resistance, therapies involving three or more drugs in combination are recommended by the World Health Organization (WHO) to suppress HIV and prevent development of acquired immune deficiency syndrome (AIDS). It is desirable for multidrug combinations to be coformulated into single dosage forms where possible, to promote patient convenience and adherence to dosage regimens, for which amorphous solid dispersion (ASD) is particularly well-suited.

Rifampin Stability and Solution Concentration Enhancement Through Amorphous Solid Dispersion in Cellulose ω-Carboxyalkanoate Matrices.

Tuberculosis (TB) is a deadly infectious disease; approximately 2 billion people are currently latently infected with the causative agent Mycobacterium tuberculosis. Approximately 8 million new active cases and 2 million deaths due to TB are recorded annually. Rifampin (Rif) is a vital first-line TB treatment drug.

Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro.

Quercetin (Q) is a bioactive flavonol with potential to benefit human health. However, Q bioavailability is relatively low, due to its poor aqueous solubility and extensive phase-II metabolism. Strategies to increase solution concentrations in the small intestinal lumen have the potential to substantially increase Q bioavailability, and by extension, efficacy.