A multicenter, cross-sectional analysis to assess the safety and usage pattern of brivaracetam in the management of partial-onset seizure with BAEs-BREEZE study: A post-hoc analysis.

Objective: Brivaracetam (BRV), a third-generation anti-seizure medication (ASM) offers strong conformational receptor domain binding, faster blood brain barrier (BBB) permeability and better tolerability making it potential therapeutic option as an initial line or initial line add-on strategy for focal onset seizure (FoS). The following study was planned to further understand the role and relevance of BRV in the real world settings of India.

Method: This was a multicentric, cross-sectional, and non-interventional study conducted in patients with FoS across India.

Leukocyte infiltration and cross-talk with cardiomyocytes exploit intracellular stress pathways in dilated cardiomyopathy of idiopathic origin.

Background And Objective: Dilated cardiomyopathy (DCM) is a prevalent form of heart failure results in dilation and disruption of heart. Most strikingly a majority of the DCM cases do not have any identified etiology, hence known as idiopathic DCM (IDCM). Our study aimed to investigate the cross-talk between leukocytes and cardiomyocytes in terms of cardiac inflammation and stress response in IDCM.

Magnetization dynamics in single and trilayer nanowires.

We have studied the magnetization dynamics of single Py() (= 20 nm, 50 nm) and trilayer [Py(50)/Pd()/Py(20)] nanowire arrays fabricated over large areas using deep ultraviolet lithography technique. The dynamic properties are sensitive to the field orientation and magnetic film thicknesses. A single resonant mode corresponding to the excitations at the bulk part of the wire is detected in all the single-layer nanowire arrays.

Effect of an external/internal magnetic field on the photocurrent in Py-topological insulator heterojunction NiFe/TI (BiTe/BiSe/BiTeSe)/p-Si devices.

This study demonstrates the fabrication and study of a permalloy (Py)/topological insulator heterojunction, , the NiFe/TI(BiTe/BiSe/BiTeSe)/p-Si heterojunction, for spintronic device applications at room temperature. In this work, the forward current values, under the absence of a magnetic field, for NiFe/BiTeSe/p-Si, NiFe/BiSe/p-Si, and NiFe/BiTe/p-Si heterojunctions were 12.7 μA, 8.

Novel Octahedral Nickel (II) Complex with Flexible Piperazinyl Moiety Exhibits Potent Cytotoxic Effect Along with Anti-Migratory and Anti-Metastatic Effect on Human Cancer Cells.

Synthesis of non-platinum transition metal complexes with N,O donor chelating ligand for application against pathogenesis of cancer with higher efficacy and selectivity is currently an important field of research. We assessed the anti-cancer effect of a mixed ligand Ni(II) complex on human breast and lung cancer cell lines in this investigation. Mononuclear mixed ligand octahedral Ni(II) complex [NiL(NO)(MeOH)] complex (1), with tri-dentate phenol-based ligand 2,4-dichloro-6-((4-methylpiperazin-1-yl) methyl) phenol (HL) along with methanol and nitrate as ancillary ligand was prepared.

Logarithmic or algebraic: Roughening of an active Kardar-Parisi-Zhang surface.

The Kardar-Parisi-Zhang (KPZ) equation sets the universality class for growing and roughening of nonequilibrium surfaces without any conservation law and nonlocal effects. We argue here that the KPZ equation can be generalized by including a symmetry-permitted nonlocal nonlinear term of active origin that is of the same order as the one included in the KPZ equation. Including this term, the 2D active KPZ equation is stable in some parameter regimes, in which the interface conformation fluctuations exhibit sublogarithmic or superlogarithmic roughness, with nonuniversal exponents, giving positional generalized quasi-long-ranged order.

Talar neck rotation angle in adults with clubfoot deformity: Observed values and intra- and inter-observer reliability using weightbearing CT.

Introduction: Adults presenting with symptomatic clubfoot represent a challenging cohort of patients. An appreciation of the location and degree of deformities is essential for management. Talar anatomy is often abnormal with varus within the talar neck, however, there are few reproducible methods which quantify talar neck deformity in adults.

Voltage-controlled magnetic anisotropy gradient-driven skyrmion-based half-adder and full-adder.

Spintronic devices have revolutionized the way we process or store information compared to dissipative charge-based electronics. Among various spin-based technologies, skyrmions - topologically protected nano-size spin textures - have emerged as the most promising alternative for future data processing. Here, we have proposed binary adder circuits - central to most digital logic circuits - based on skyrmions.

Differential expansion and retention patterns of LRR-RLK genes across plant evolution.

To maximize overall fitness, plants must accurately respond to a host of growth, developmental, and environmental signals throughout their life. Many of these internal and external signals are perceived by the leucine-rich repeat receptor-like kinases, which play roles in regulating growth, development, and immunity. This largest family of receptor kinases in plants can be divided into subfamilies based on the conservation of the kinase domain, which demonstrates that shared evolutionary history often indicates shared molecular function.

CoSIA: an R Bioconductor package for CrOss Species Investigation and Analysis.

Summary: High-throughput sequencing technologies have enabled cross-species comparative transcriptomic studies; however, there are numerous challenges for these studies due to biological and technical factors. We developed CoSIA (Cross-Species Investigation and Analysis), a Bioconductor R package and Shiny app that provides an alternative framework for cross-species transcriptomic comparison of non-diseased wild-type RNA sequencing gene expression data from Bgee across tissues and species (human, mouse, rat, zebrafish, fly, and nematode) through visualization of variability, diversity, and specificity metrics.

Availability And Implementation: https://github.

Proximity induced band gap opening in topological-magnetic heterostructure (NiFe/p-TlBiSe/p-Si) under ambient condition.

The broken time reversal symmetry states may result in the opening of a band gap in TlBiSe leading to several interesting phenomena which are potentially relevant for spintronic applications. In this work, the quantum interference and magnetic proximity effects have been studied in NiFe/p-TlBiSe/p-Si (Magnetic/TI) heterostructure using physical vapor deposition technique. Raman analysis shows the symmetry breaking with the appearance of A mode.

Hindfoot Fusions in the Cavovarus Foot: What Is the Key for a Successful Outcome?

The aim of hindfoot fusions in the cavovarus foot is to establish a painless, plantigrade, balanced and stable foot. A comprehensive clinical and radiographic assessment enables the surgeon to fully understand the patient's deformity and plan a reliable surgical strategy for deformity correction. Pre-operative planning and intraoperative techniques are discussed.

Mobility-induced order in active XY spins on a substrate.

We elucidate that the nearly phase-ordered active XY spins in contact with a conserved, diffusing species on a substrate can be stable. For wide-ranging model parameters, it has stable uniform phases robust against noises. These are distinguished by generalized quasi-long-range (QLRO) orientational order logarithmically stronger or weaker than the well-known QLRO in equilibrium, together with miniscule (i.

Active XY model on a substrate: Density fluctuations and phase ordering.

We explore the generic long-wavelength properties of an active XY model on a substrate, consisting of a collection of nearly phase-ordered active XY spins in contact with a diffusing, conserved species, as a representative system of active spinners with a conservation law. The spins rotate actively in response to the local density fluctuations and local phase differences, on a solid substrate. We investigate this system by Monte Carlo simulations of an agent-based model, which we set up, complemented by the hydrodynamic theory for the system.

Hidden Critical Points in the Two-Dimensional O(n>2) Model: Exact Numerical Study of a Complex Conformal Field Theory.

The presence of nearby conformal field theories (CFTs) hidden in the complex plane of the tuning parameter was recently proposed as an elegant explanation for the ubiquity of "weakly first-order" transitions in condensed matter and high-energy systems. In this work, we perform an exact microscopic study of such a complex CFT (CCFT) in the two-dimensional O(n) loop model. The well-known absence of symmetry-breaking of the O(n>2) model is understood as arising from the displacement of the nontrivial fixed points into the complex temperature plane.

Evaluation of community-based care delivered by primary healthcare providers in management of hypertension in a rural area of West Bengal.

Background: Lifestyle modifications and medication compliance are key strategies.

Objectives: To evaluate the effect of community-based care delivered by trained primary healthcare providers in management of hypertension.

Materials And Methods: A longitudinal study was conducted between two groups of newly diagnosed hypertensive patients to evaluate the impact of an educational intervention.

Anomalous Collective Dynamics of Autochemotactic Populations.

While the role of local interactions in nonequilibrium phase transitions is well studied, a fundamental understanding of the effects of long-range interactions is lacking. We study the critical dynamics of reproducing agents subject to autochemotactic interactions and limited resources. A renormalization group analysis reveals distinct scaling regimes for fast (attractive or repulsive) interactions; for slow signal transduction, the dynamics is dominated by a diffusive fixed point.

Chemical Approach Towards Broadband Spintronics on Nanoscale Pyrene Films.

The injection of pure spin current into the non-magnetic layer plays a crucial role in transmitting, processing, and storing data information in the realm of spintronics. To understand broadband molecular spintronics, pyrene oligomer film (≈20 nm thickness) was prepared using an electrochemical method forming indium tin oxide (ITO) electrode/pyrene covalent interfaces. Permalloy (Ni Fe ) films with different nanoscale thicknesses were used as top contact over ITO/pyrene layers to estimate the spin pumping efficiency across the interfaces using broadband ferromagnetic resonance spectra.

Development of B cell epitopes-based enzyme linked immune sorbent assay for detection of bovine anti-Mullerian hormone.

The present study aimed to generate antibodies against predicted B cell epitopic peptides encoding bAMH for developing different ELISA models. Sandwich ELISA was determined to be an excellent technique for assessing bAMH in bovine plasma based on sensitivity tests. The assay's specificity, sensitivity, inter- and intra-assay CV, recovery %, Lower limit of quantification (LLOQ), and Upper limit of quantification (ULOQ) were determined.

Quantifying transcriptome diversity: a review.

Following the central dogma of molecular biology, gene expression heterogeneity can aid in predicting and explaining the wide variety of protein products, functions and, ultimately, heterogeneity in phenotypes. There is currently overlapping terminology used to describe the types of diversity in gene expression profiles, and overlooking these nuances can misrepresent important biological information. Here, we describe transcriptome diversity as a measure of the heterogeneity in (1) the expression of all genes within a sample or a single gene across samples in a population (gene-level diversity) or (2) the isoform-specific expression of a given gene (isoform-level diversity).

CoSIA: an R Bioconductor package for CrOss Species Investigation and Analysis.

High throughput sequencing technologies have enabled cross-species comparative transcriptomic studies; however, there are numerous challenges for these studies due to biological and technical factors. We developed CoSIA (Cross-Species Investigation and Analysis), an Bioconductor R package and Shiny app that provides an alternative framework for cross-species transcriptomic comparison of non-diseased wild-type RNA sequencing gene expression data from Bgee across tissues and species (human, mouse, rat, zebrafish, fly, and nematode) through visualization of variability, diversity, and specificity metrics.