The Antinociceptive Effects and Sex-Specific Neurotransmitter Modulation of Metformin in a Mouse Model of Fibromyalgia.

Fibromyalgia (FM) is a chronic and debilitating condition characterized by diffuse pain, often associated with symptoms such as fatigue, cognitive disturbances, and mood disorders. Metformin, an oral hypoglycemic agent, has recently gained attention for its potential benefits beyond glucose regulation. It has shown promise in alleviating neuropathic and inflammatory pain, suggesting that it could offer a novel approach to managing chronic pain conditions like FM.

Efficacy of the Modified Alvarado Scoring System and Radiologic Studies in Diagnosing Appendicitis in Children: A Retrospective Comparative Study.

Background: Appendicitis is a common diagnostic challenge in pediatric patients. Based on clinical and laboratory findings, the modified Alvarado scoring system (MAS) is commonly used to assess the likelihood of appendicitis. This study aims to evaluate the diagnostic performance of MAS compared to radiologic findings and its components in the diagnosis of appendicitis in children.

Incidence and predictive factors of bleeding following tonsillectomy among pediatrics: A retrospective cohort study.

Objectives: To estimate the incidence of post tonsillectomy bleeding and to identify its predisposing factors among the pediatric population.

Methods: A retrospective cohort study included 1280 pediatric patients (18 years or younger) who underwent tonsillectomy at King Abdullah Specialized Children Hospital, Riyadh, Saudi Arabia between 2019 and 2020. The study sample was divided into 2 groups based on the development of postoperative bleeding and were compared using Chi-square test and independent t-test.

Randomized clinical trial of zirconia laminate veneers sintered by using conventional versus speed process: 1-year follow-up.

Statement Of Problem: The application of highly translucent multilayered zirconia ceramic in minimally invasive esthetic dentistry allows the achievement of both esthetics and strength with minimal thickness. Clinical studies that have assessed the performance of zirconia ultrathin veneers sintered with the conventional and speed procedure are lacking.

Purpose: The purpose of this clinical study was to evaluate the effect of speed sintering processes on the translucency and clinical performance of zirconia laminate veneers.

Analysis of the Marginal Continuity in Different Designs of Monolithic Zirconia Inlay-Retained Fixed Dental Prostheses: An In Vitro Study.

Purpose: To evaluate the marginal integrity of three inlay-retained fixed dental prosthesis (IRFDP) designs fabricated using monolithic zirconia.

Materials And Methods: In total, 30 IRFDPs were fabricated using 4-YTZP monolithic zirconia and randomly divided into three groups according to the cavity design. Groups ID2 and ID1.

Preparation of ultrathin translucent zirconia laminate veneers using 3D printing reduction guides.

Minimizing and controlling the amount of tooth reduction during the preparation of ultrathin laminate veneers is a challenge for minimally invasive dentistry. The use of reduction guides is advised to reach the optimal space required for the definitive restoration without excessive reduction. The digital production of a reduction guide used to control tooth preparation for ultrathin laminate veneers is described.

Translucency of recent zirconia materials and material-related variables affecting their translucency: a systematic review and meta-analysis.

Background: Recent forms of translucent zirconia material have been developed, offering a wide range of options and varieties for enhancing aesthetics, making it a preferred choice in the field of prosthetic dentistry. However, there is insufficient understanding regarding the recent types of zirconia materials and their optical behavior. Understanding the variables that influence the translucency of zirconia and identifying strategies to enhance its esthetics are crucial.

The Pattern and Influencing Factors of Opioid-Prescribing Behavior Among Emergency Physicians: A Cross-Sectional Study in the Western Region of Saudi Arabia.

Background In the last two decades, drug overdose has globally become a major player in patients' morbidity and mortality events. Opioids, in particular, have been always the main part of this equation in different communities as they correspond, for instance, to one-third of poisoning deaths in The United States of America (USA).  Aim This study aimed to measure the variation in opioid-analgesia (OA) prescription behavior among emergency medicine (EM) physicians working in different hospitals in the Western Region of Saudi Arabia.

Effect of sintering time on microstructure and optical properties of yttria-partially stabilized monolithic zirconia.

Objectives: To evaluate the impact of speed sintering on the microstructure and optical properties of 3 and 5 mol% yttria-partially stabilized monolithic zirconias.

Methods: 120 plate-shaped zirconia specimens (10x10x 0.4 mm) were prepared from three commercial 5 mol% yttria-partially stabilized zirconia blocks (5Y-PSZs); Katana UTML (Kuraray Noritake), Cercon xtML (Dentsply Sirona), and Zolid FX white (Amann Girrbach), and two commercial 3 mol% yttria-partially stabilized zirconia blocks (3Y-PSZs); Lava Plus (3 M ESPE) and InCoris (Sirona, GmbH).

The potential protectivity of honey and olive oil in methotrexate induced renal damage in rats.

Methotrexate (MTX) is an antimetabolite used to treat inflammatory diseases, autoimmune disorders and some malignancies. However, it has some life-threatening side effects such as nephrotoxicity which limit its clinical applications. That motivated the attention to seek for a defensive material to improve the outcomes of methotrexate while minimizing both renal and non-renal toxicity.

Efficacy of Cricotracheal Stenosis Resection (CTSR) Among Children with Congenital vs. Acquired Sub-glottic Stenosis.

Sub-glottic Stenosis (SGS) treatment in children is challenging because there is no standard algorithm to follow; however, the use of endoscopic techniques in SGS treatment has emerged over the last decades and has advanced. The aim of this study was to assess the efficacy of Cricotracheal Stenosis Resection (CTSR) among children with congenital vs. acquired SGS.

Comparison and Effect of Common Beverages on Color Stability of Different Esthetic Restorative Materials: An Study.

Aim: The aim of this study is to assess the color stability of different esthetic veneer restorative materials (feldspathic ceramic, hybrid ceramic, zirconia-reinforced lithium silicate glass ceramic, and composite resin) after being exposed to commonly consumed beverages that have staining potential.

Materials And Methods: Sixty specimens were prepared into rectangular blocks with fixed dimensions of 10 × 12 × 2.5 mm.

Targeted differential photostimulation alters reproductive activities of domestic birds.

Modern poultry production systems use environmentally controlled houses providing only artificial illumination. The role of light in reproduction of poultry depends on light quality (photoperiod, intensity/brightness, and spectrum), which enables us to provide custom-made illumination, targeted for the elevation of reproductive activities. Artificial targeted illumination significantly affects poultry reproduction.

The Use of Inflammatory Markers to Rule Out Acute Appendicitis in Pediatrics.

Background Acute appendicitis is the most common abdominal surgical emergency in pediatric patients. The diagnosis of acute appendicitis in pediatrics is challenging and requires an accurate physical examination, laboratory study, and imaging. The aim of this study was to determine the benefits of using three inflammatory markers, white blood count (WBC), neutrophils percent (NE%), and C-reactive protein (CRP), in ruling out appendicitis in pediatric patients.

Evaluation of the Potential Protectivity of Both and on the Cadmium-Induced Testicular Damage in Rats.

Background: Cadmium (Cd) is a widely spread environmental pollutant, listed among the unsafe metals due to known toxic effects on multiple organs, including the testes. In this study, we aim to evaluate the potential protectivity of garlic and ginger extracts on Cd-induced damage of the testis in rats.

Materials And Methods: Fifty-six adult male albino rats were alienated into seven groups; control group, garlic-treated group, and ginger-treated group were given garlic and ginger extracts at doses of 250 mg and 120 mg/kg b.

Evidence-Based Interventions Implemented into HIV Primary Care Clinics to Make Sexually Transmitted Infection Screening and Testing Routine: Outcomes of a Multi-Site Study.

In response to rising rates of bacterial sexually transmitted infections (STIs) in the United States, this evaluative study of the implementation of four evidence-based interventions was developed and implemented. In three STI and HIV high-incidence jurisdictions of the United States, nine federally funded Health Resources and Services Administration Ryan White HIV/AIDS Program clinical demonstration sites implemented (1) audio computer-assisted self-interview sexual history taking, (2) patient self-collection of urogenital and extragenital site chlamydia/gonorrhea nucleic acid amplification test specimens, (3) sexual and gender minority welcoming indicators, and (4) provider training, to make STI screening, testing, and treatment routine in their HIV primary care clinics. The priority populations of young adults, men who have sex with men, and sexual and gender minority patients were found to have risk behaviors identified in the self-interview sexual history, to prefer to self-collect urogenital and extragenital site specimens for STI testing, and to notice and like the sexual and gender minority welcoming indicators.

Facilitators and Barriers to the Implementation of Interventions in Washington, DC, to Improve Sexually Transmitted Infection Screening, Testing, and Treatment Among People with or at Risk of HIV.

Bacterial sexually transmitted infection (STI) incidences of gonorrhea, chlamydia, and syphilis are increasing in Washington, DC. Moreover, the availability of HIV pre-exposure prophylaxis for people at risk of HIV and condomless sex has increased, and bacterial STI rates have risen. This indicates the necessity of evidence-based strategies to ensure access to STI care and improve health outcomes for people with HIV in Washington, DC.

Public awareness of the neurological manifestation of COVID-19 in Saudi Arabia.

Objectives: To assess awareness of the neurological manifestation of COVID-19 on the Saudi population.

Methods: This was a cross-sectional study conducted using a Google Form survey to obtain responses randomly from the Saudi population between February and March 2021 using social media.

Results: A total of 831 participants completed the questionnaire.

Improving sexually transmitted infection screening, testing, and treatment among people with HIV: A mixed method needs assessment to inform a multi-site, multi-level intervention and evaluation plan.

Bacterial sexually transmitted infections (STIs) continue to be a worsening public health concern in the United States (US). Though the national incidence of HIV infection has decreased over recent years, that of chlamydia, gonorrhea, and syphilis have not. Despite national recommendations on prevention, screening, and treatment of these STIs, these practices have not been standardized.

Academic and non-academic life stressors and their impact on psychological wellbeing of medical students.

Objectives: Among medical students, depression, anxiety, and stress (DAS) are key public wellbeing challenges that require epidemiological research. We aimed to evaluate potential sources of these psychological disturbances and assess the contribution of academic and non-academic life stressors in psychological morbidity among medical students.

Methods: This exploratory questionnaire-based survey was conducted in a Saudi Arabian public sector medical college.

Prevalence of Helicobacter pylori Infection Among Rosacea and Chronic Spontaneous Urticaria Patients in a Tertiary Hospital in Riyadh, Saudi Arabia.

Background: The multifactorial nature of rosacea and chronic spontaneous urticaria (CSU) pathogenesis complicates the achievement of satisfactory treatment outcomes. 13C urea breath test (UBT) has been identified as an accurate, non-invasive, and quick procedure to detect the presence of () with high sensitivity and specificity.

Objective: In this study, we aim to assess the correlation between infection and rosacea and CSU patients.

Job satisfaction among Saudi healthcare workers and its impact on the quality of health services.

Background: Job satisfaction among health care workers is crucial and considered as an essential parameter that affects their productivity and work's quality.

Methods: A cross-sectional questionnaire-based study was conducted among health care workers in Saudi, males and females, to assess the impact of job satisfaction on health service quality. A random sampling technique was applied to select the participants.

Safety and Efficacy of Maxitrol in Pediatric Age Group Below Two Years With Adenoid Hypertrophy: A Retrospective Cohort Study.

Introduction Adenoid hypertrophy, a common condition in children, represents one of the common indications for surgery in pediatrics. Medical treatment alone is not effective, and most of the time patients are managed by surgical removal of the adenoid. The aim of this study is to assess the safety and efficacy of intranasal Maxitrol® drops (Novartis Pharmaceuticals, Basel, Switzerland) in pediatric patients with adenoid hypertrophy aged less than two years and to document any side effects during its use.