Publications by authors named "Hala Bayoumi"
Cancers utilize a simple glycan, Sialic Acid, to engage in metastatic processes via the Sialic acid (Sia) -Selectin pathway. Selectins recognize and bind to sialylated substrates, resulting in adhesion, migration, and extravasation, however, how deviations from the canonical form of Sia regulate binding to Selectin receptors (E, L, and P) on hemopoietic cells resulting in these metastatic processes, remained a gap in knowledge. De-O-acetylated Sias has been recently shown to be an integral substrate to the binding of sialic acid binding proteins.
View Article and Find Full Text PDFArticle Synopsis
- Cancers use sugar molecules called glycans, particularly sialic acid (Sia), to develop resistance to multiple drugs, but the specific mechanisms behind this are not fully understood.
- Modifying the presence of Sia on the Breast Cancer Resistance Protein (BCRP), a key protein in this resistance process, affects the ability of lung and colon cancer cells to retain or expel chemotherapy drugs.
- Research involving gene editing and various analysis techniques showed that lower levels of acetylated Sia led to increased BCRP activity, reduced sensitivity to the drug Mitoxantrone, and enhanced cancer cell survival and growth, with implications for the management of lung adenocarcinoma.