5-nitro isatin containing heterocyclics derivatives: synthesis, antioxidant activity, anticancer activity and molecular docking.

The manuscript describes the synthesis of eight Novel 1,2,4-triazine and 1,2-diazino derivatives having the 5-nitro isatin moiety. Antiradical and anticancer activities were evaluated using the DPPH method and the MTT assay against breast cancer (MCF-7) cell lines. The compound with the strongest antioxidant and anticancer properties after 24 h was (1,2,4-triazine-3-thione) but after 48 h, (1,2,4- triazine-3-ol) with good anticancer activity while (1,2-diazino) after 72 h.

Synthesis, identification and evaluation of molecular docking and experimental anti-cancer and antioxidant activity of new spiro four membered ring derivatives bearing 5-nitro isatin.

Spiro-5-nitro isatino aza-β-lactams were produced by a [2 + 2] cycloaddition of 5-nitro isatin Schiff bases [1-5] with different aromatic isocyanate and thioisocyanate. 1HNMR and 13CNMR as well as FTIR spectroscopies, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin aza- β-lactams interest to us due to their potential antioxidant and anticancer properties.