Publications by authors named "Hala Awada"
Article Synopsis
- Glioblastoma (GBM) is a very aggressive brain tumor with treatment challenges due to its complex and varying characteristics; this study focuses on the metabolic features of Glioblastoma stem cells (GSC) that are crucial for tumor growth and resistance to therapies.
- Researchers performed extensive analyses on brain tumor cultures and found that GSCs have unique glycolytic profiles compared to regular tumor cells, heavily relying on the enzyme pyruvate carboxylase (PC) for their survival and growth.
- Inhibiting PC leads to GSC death, increases differentiation, and can restore sensitivity to the chemotherapy drug etoposide, indicating that targeting PC could be an effective strategy to combat therapy resistance in GBM.
Cancer treatment protocols depend on tumor type, localization, grade, and patient. Despite aggressive treatments, median survival of patients with Glioblastoma (GBM), the most common primary brain tumor in adults, does not exceed 18 months, and all patients eventually relapse. Thus, novel therapeutic approaches are urgently needed.
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