Relative fluoride response of caries lesions created in fluorotic and sound teeth studied under remineralizing conditions.

Objectives: The present in vitro pH cycling study investigated potential differences between caries lesions created in fluorosed and sound enamel with regards to their responsiveness to fluoride under remineralizing conditions.

Methods: 360 human first molars (sound and fluorosed) were divided into four groups based on their Thylstrup-Fejerskov score (TF0-3). Each group was further divided into two treatment groups (n=45): deionized water or 383 ppm fluoride.