Publications by authors named "Hala A AbdelRahman"
Article Synopsis
- SALL4 is a transcription factor that keeps stem cells undifferentiated and is involved in leukemia development, specifically affecting leukemic stem cells.
- The study analyzed SALL4 gene expression in 106 patients with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) using real-time PCR, finding increased levels in both types of leukemia.
- Higher SALL4 expression in AML patients correlated with worse disease-free survival rates, indicating its potential as a prognostic marker in these leukemias.
Sickle cell disease (SCD) is associated with a pro-inflammatory state, characterized by an elevated baseline leukocyte count and inflammatory cytokines. Inflammation, white blood cell (WBC) adhesion to vascular endothelium with subsequent endothelial injury, and repeated ischemia-reperfusion injury contribute to disease pathogenesis. Identification of genetic polymorphisms that may modulate disease severity in SCD is becoming a field of interest.
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