Aerobic interval training preconditioning protocols inhibit isoproterenol-induced pathological cardiac remodeling in rats: Implications on oxidative balance, autophagy, and apoptosis.

This study aimed to investigate the potential cardioprotective effects of moderate and high-intensity aerobic interval training (MIIT and HIIT) preconditioning. The focus was on histological changes, pro-oxidant-antioxidant balance, autophagy initiation, and apoptosis in myocardial tissue incited by isoproterenol-induced pathological cardiac remodeling (ISO-induced PCR). Male Wistar rats were randomly divided into control ( ​= ​6), ISO ( ​= ​8), MIIT ( ​= ​4), HIIT ( ​= ​4), MIIT ​+ ​ISO ( ​= ​8), and HIIT ​+ ​ISO ( ​= ​8) groups.