Cutaneous morphometric parameters of young FVB/N mice sustained in aged mice and in calorically restricted transgenic alphaMUPA mice.

Caloric restriction (CR) extends the lifespan of diverse animal species and is currently the only therapeutic intervention known to attenuate aging and increase longevity in laboratory animals. The effect of CR on intrinsic skin aging is not well understood. To study this issue, we took advantage of transgenic alphaMUPA mice that spontaneously eat less (20-30%) when fed ad libitum and live longer compared to their wild type (WT) FVB/N control mice.